Preparation, Assay, and Preliminary Characterization of Bovine Gastrin

Anderson, Walter R.; Fletcher, T. Lloyd; McAlexander, Robert A.; Pitts, Clifford L.; Cohen, Richard L.; Harkins, Henry N.

doi:10.3168/jds.s0022-0302(61)90048-0

Cited by 14 publications

(1 citation statement)

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“…There is both direct and indirect evidence that the antral region produces gastrin which can influence secretion from the fundus. For example gastrin is present in extracts of abomasal pyloric antral mucosa (Anderson et al 1961(Anderson et al , 1962Amure & Omole, 1971), and cholinergic stimulation of antral pouches of the abomasum stimulated acid secretion from fundic pouches (McLeay & Titchen, 1971). This response is comparable to effects described in studies on the control of acid secretion made in the dog in which a local nervous mechanism has been postulated for stimulation of gastrin secretion in response to physical and chemical stimulation of the antrum (Schofield, 1966).…”

Section: Discussionmentioning

confidence: 99%

Gastric, antral and fundic pouch secretion in sheep.

McLeay¹,

Titchen²

1975

The Journal of Physiology

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SUMMARY1. Fundic secretion of HC1 and pepsin was studied in sheep with both fundic and antral pouches. The antral pouches were of the entire pyloric region. Continuity of the alimentary tract was restored by an abomasoduodenal anastomosis.2. Secretion from fundic pouches was continuous. It was reduced in volume and acidity, as was pepsin output, by resection of the antral pouches.3. Teasing with food, feeding and injection of pentagastrin stimulated fundic acid and pepsin secretion in animals with antral pouches before and after antrectomy.4. Pouches prepared from the entire pyloric region showed continuous secretion with variations not related to feeding or fasting. Antral secretion was increased after s.c. injections of histamine, carbachol and pentagastrin.5. It is concluded that although the pyloric antrum contributes to the magnitude of the secretary response of an abomasal fundic pouch, the direction of the secretary response is similar whether or not the pyloric antrum is present as a separated pouch, or is removed.

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Section: Discussionmentioning

confidence: 99%