Preparation, Antibacterial Activity, and Catalytic Application of Magnetic Graphene Oxide‐Fucoidan in the Synthesis of 1,4‐Dihydropyridines and Polyhydroquinolines

Abstract

Polymer‐coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan‐coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaFe 12 O 19 @GO@Fu (Fu=fucoidan, GO=graphene oxide) was characterized using Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray (EDX) analysis, vibrating sample magnetometry (VSM), thermogravimetric analysis (TGA), Raman spectroscopy, and X‐ray diffraction (XRD). The catalytic proficiency of BaFe 12 O 19 @GO@Fu was investigated in the synthesis of 1,4‐dihydropyridine and polyhydroquinoline derivatives. Excellent turnover numbers (TON) and turnover frequencies (TOF) (6330 and 25320 h −1 ) testify to the high efficiency of the catalyst. Moreover, the antimicrobial activity of BaFe 12 O 19 @GO@Fu was evaluated against Escherichia coli (E. coli) , and Staphylococcus aureus ( S. aureus ) through the Agar well diffusion method, indicating that BaFe 12 O 19 @GO@Fu has antibacterial activity against S. aureus .

1,4-Dihydropyridine as a Promising Scaffold for Novel Antimicrobials Against Helicobacter pylori

“…Since then, the antitubercular properties of other DHP derivatives have been reported by many other researchers ( Trivedi et al, 2011 ; Desai et al, 2015 ; Zandhaghighi et al, 2017 ; Venugopala et al, 2021 ). DHPs have been also evaluated as antimicrobials against other pathogenic bacteria including S. aureus ( Ceviz et al, 1997 ; Olejnikova et al, 2014 ; Mahmoodi et al, 2015 ; Nkosi et al, 2016 ; Nosrati et al, 2021 ), E. coli ( Murthy et al, 2012 ; Olejnikova et al, 2014 ; Mahmoodi et al, 2015 ; Nkosi et al, 2016 ; Ahamed et al, 2018 ), Pseudomonas aeruginosa ( Mahmoodi et al, 2015 ; Nkosi et al, 2016 ; Ahamed et al, 2018 ), Vibrio cholerae ( Lavanya et al, 2021 ) and Klebsiella pneumoniae ( Murthy et al, 2012 ); but also against parasites ( Núñez-Vergara et al, 1997 ; Palit and Ali, 2008 ; Reimao et al, 2010 ; Pollo et al, 2017 ; Jeddi et al, 2021 ) and fungi ( Chhillar et al, 2006 ; Jezikova et al, 2017 ; Ahamed et al, 2018 ). This class of molecules have been also studied as inhibitors of bacterial transmembrane efflux pumps, acting thereby as enhancers of the action of conventional antibiotics ( Lentz et al, 2016 , 2018 , 2019 ).…”

Synthesis, Antibacterial Activities and Theoretical Study of Polyhydroquinoline Derivatives

“…[38] In recent years, Nosrati et al synthesized number of polyhydroquinoline derivatives (c) and investigated their antimicrobial activities which exhibit good activity against gram-positive bacteria S. aures. [39] Similarly, Zainab et al reported various compounds based on PHQ nucleus, which exhibit significant antibacterial activity against Escherichia coli (gram-negative bacterium)…”

“…In recent years, Nosrati et al . synthesized number of polyhydroquinoline derivatives ( c ) and investigated their antimicrobial activities which exhibit good activity against gram‐positive bacteria S. aures [39] . Similarly, Zainab et al .…”

CuFe2O4@SiO2@L-arginine@Cu(I) as a new magnetically retrievable heterogeneous nanocatalyst with high efficiency for 1,4-disubstituted 1,2,3-triazoles synthesis

“…In continuation of our work on the synthesis of heterocyclic structures 22 – 24 , we reported the synthesis of a new efficient magnetite-base catalytic system, CuFe 2 O 4 @SiO 2 @l-arginine@Cu, along with its application in an approach to 1,2,3-triazole derivatives. The procedure uses phenylacetylene as an alkyne, sodium azide, and various alkyl halides as the other component to form triazoles.…”