Preparation and the in Vitro Evaluation of Nanoemulsion System for the Transdermal Delivery of Granisetron Hydrochloride

Zheng, Wenwu; Zhao, Ling; Wei, Yumeng; Ye, Yun; Shun-han, Xiao

doi:10.1248/cpb.58.1015

Cited by 39 publications

(18 citation statements)

References 27 publications

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“…23 Further, n-methyl-pyrrolidone is used as a solubilizing agent in pharmaceutical formulations for oral and parenteral use and as a penetration enhancer for lipophilic drugs. 24 These characteristics make n-methyl-pyrrolidone an ideal candidate, and recently they have been exploited in applications testing the efficacy of n-methyl-pyrrolidone in transdermal nanosystems containing granisetron hydrochloride, 25 and in formulations designed for topical use, such as lidocaine, 26 estradiol, 27 bupranolol, 28 and insulin. 29 In formulations intended for topical administration, the aqueous phase and surfactants affect skin permeability by hydration of the stratum corneum and breakdown of the lipoprotein matrix, resulting in decreased resistance to drug diffusion.…”

Section: Resultsmentioning

confidence: 99%

“…The results were analyzed statistically using linear regression and the least squares method. Precision was determined by evaluating repeatability, while the intermediate precision of the measurements was tested using standards with concentrations of 80%, 100%, and 120% (20,25, and 30 µg/mL), with three replicates each. The relative standard deviation was calculated and a value obtained below 2% was considered acceptable.…”

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confidence: 99%

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Nanoemulsion containing dapsone for topical administration: a study of in vitro release and epidermal permeation

Borges¹,

Simon²,

Sena³

et al. 2013

IJN

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Background: Topical administration of dapsone can be an alternative route for treatment of leprosy and can also provide new therapeutic applications for an established drug. However, the physicochemical properties of dapsone make it difficult to incorporate into conventional formulations. The current study was directed toward developing a stable nanoemulsion that contains dapsone which can be adapted for topical use. Methods: Nanoemulsions were prepared using isopropyl myristate or n-methyl-pyrrolidone as the oil phase, and characterized according to their mean droplet size, conductivity, refractive index, pH, drug content, and stability. The in vitro release of dapsone and its ability to permeate the epidermis were also evaluated. Results: Physicochemical characterization demonstrated that nanosystems were formed, which had a uniform droplet distribution and a pH compatible with the skin surface. Use of n-methyl-pyrrolidone provided a greater nanoemulsion region and higher solubilization of dapsone, and increased the in vitro release rate when compared with a nanoemulsion prepared using isopropyl myristate. However, use of isopropyl myristate promoted an increase in in vitro epidermal permeation that followed the Higuchi model. This demonstrates the ability of a nanosystem to influence permeation of dapsone through the skin barrier. Furthermore, the nanoemulsions developed and evaluated here had ideal physicochemical stability over a 3-month period. Conclusion: Incorporation of dapsone into a nanoemulsion may be a promising system for enabling topical delivery of dapsone, while minimizing skin permeation, for the treatment of acne. The method developed here used isopropyl myristate as the oil phase, and promoted permeation of dapsone through the skin barrier for the treatment of leprosy upon use of n-methylpyrrolidone as the oil phase.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Nanoemulsion containing dapsone for topical administration: a study of in vitro release and epidermal permeation

Borges¹,

Simon²,

Sena³

et al. 2013

IJN

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“…10 Nanoemulsions exhibit unique advantages and properties, such as reduced droplet size with larger surface area, improved drug solubility and dissolution rates, and enhanced drug absorption from the gastrointestinal tract by surfactant-induced mucosal permeability changes. [11][12][13][14][15][16][17][18][19] Nanoemulsion formulations have been widely used to overcome problems related to the poor water solubility and low oral bioavailability of some drugs.…”

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confidence: 99%

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Zhao¹,

Wei²,

Huang³

et al. 2013

IJN

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112

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“…The nanoparticles were fixed on supports, and coated with gold under an argon atmosphere using a gold sputter module in a high-vacuum evaporator. Samples were then observed with the scanning electron microscope at 200 kV (W. Zheng et al, 2010).…”

Section: Scanning Electron Microscopic Studies (Sem)mentioning

confidence: 99%

Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Selegiline

Goswami

Madhav

Upadhyaya³

2016

Int Curr Pharm J

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The purpose of the present study was to formulate and evaluate Selegiline loaded bio-nanoparticles for effective treatment of Depression. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Luffa acutangula by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, color changing point and chemical test. Bio-nanoparticles were prepared by modified solvent evaporation method in different batches with variable drug/biomaterial ratio. Prepared batches were subjected for various evaluation studies like particle size, zeta potential, SEM, TEM, surface entrapment, in-vitro diffusion, DSC and stability. Particle size and zeta potential result revealed that all nanoformulation were within range of 110 to 152.7 with slight negative in charge. SEM and TEM study report indicate that formulations were spherical in shape with less or no aggregation. Less surface entrapment leads to better drug entrapped inside nanomatrix. Bio-nanoformulations were capable of releasing the drug in a slow sustained manner. From the present investigation, it may be concluded that biomaterial isolated from fruits of Luffa acutangula used in the preparation of bio-nanoparticle act as an efficient carriers for deliver selegiline at a controlled rate. It may significantly improve the ability to cross blood-brain barrier and serve as an effective tool to treat Depression disease.Goswami et al., International Current Pharmaceutical Journal, March 2016, 5(4): 33-37http://www.icpjonline.com/documents/Vol5Issue4/01.pdf

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Preparation and the in Vitro Evaluation of Nanoemulsion System for the Transdermal Delivery of Granisetron Hydrochloride

Cited by 39 publications

References 27 publications

Nanoemulsion containing dapsone for topical administration: a study of in vitro release and epidermal permeation

Nanoemulsion containing dapsone for topical administration: a study of in vitro release and epidermal permeation

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Selegiline

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