Preparation and Synthetic Applications of Five-to-Seven-Membered Cyclic α-Diazo Monocarbonyl Compounds

Abstract

The reactivity of cyclic α-diazo monocarbonyl compounds differs from that of their acyclic counterparts. In this review, we summarize the current literature available on the synthesis and synthetic applications of three major classes of cyclic α-diazo monocarbonyl compounds: α-diazo ketones, α-diazo lactones and α-diazo lactams.

DFT Study on Mechanism of Ni–Al Bimetallic-Catalyzed C–H Cyclization to Construct Tricyclic Imidazoles: Roles of NHC Ligand and AlMe3

“…Tricyclic imidazoles and their 7-membered ring derivatives, as one of the most important classes of structural motifs, − are widely present in numerous biologically active material molecules. Owing to their significance, the synthesis of tricyclic imidazoles and their 7-membered ring derivatives − has attracted widespread attention, and extensive effort has been devoted to the development of new methodologies. − Among a large number of strategies, direct construction of a 7-membered ring via C7–H cyclization of benzimidazoles with alkenes would provide a more straightforward, atom- and step-economic access to tricyclic imidazoles from more easily accessible substrates. However, over the past few decades, transition metal-catalyzed C–H cyclization − for medium-ring synthesis has been a challenging goal.…”