Preparation and study on miscibility, thermal behavior of biocompatible polymer blends of xanthan Gum-polyacrylamide

BackgroundCommunity and hospital pharmacists are always face the challenge to prepare oral liquid extemporaneous formulations to t the needs of a speci c patient population when commercial forms or the required strength are unavailable. AimThis study was performed to prepare a stable patient-friendly oral liquid extemporaneous formulations of bisoprolol. MethodEight different extemporaneous formulations were prepared using various suspending agent(s). The in vitro dissolution of all extemporaneous formulations was examined. A comprehensive accelerated stability study was carried out to evaluate the adequate beyond-use date of the most optimized extemporaneous formulation. A validated UPLC method was used for the analysis and quanti cation of bisoprolol in the accelerated stability and bioavailability studies. A group of eight healthy volunteers was enrolled in a two-way cross-over experimental design to study the bioavailability of the most optimized extemporaneous formulation. The pharmacokinetic parameters of bisoprolol were estimated. ResultsExtemporaneous suspension contain 0.5% w/v xanthan gum was easily prepared with a simple, natural, safe, sugar free excipients. It achieved the best dissolution behavior among other extemporaneous suspensions. It was an easily pourable viscous suspension with no sedimentation. At least 98% of the initial concentration of bisoprolol remained throughout the 6-month study period in the selected suspension regardless of the storage conditions. There was no perceptible change in color, odor or taste, and no noticeable microbial growth was observed in any sample. The selected formulation was bioequivalent to the commercial tablet in terms of the rate and extent of absorption. ConclusionThis research may be of great help during development of appropriate extemporaneous formulation of bisoprolol fumarate. The simple preparation method could be utilized to draw up a Standard Operating Procedure (SOP) easy to use by different types of pharmacy settings.

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“…4b). A similar absorption bands concurred with those published earlier for the same polymer [74,75] (Fig. 3b).…”

Section: Fourier Transform Infrared Spectrophotometry (Ft-ir)supporting

confidence: 92%

Patient-friendly extemporaneous formulation of bisoprolol: application to stability and bioavailability studies

El-Masry

Helmy

et al. 2022

Drug Deliv. and Transl. Res.

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“…Low miscibility or immiscibility of natural and synthetic polymers usually limits the development of homogeneous blends of natural-synthetic polymers [27][28][29][30][31]. The hydrophobic character of synthetic polymers such as PCL, polyacrylamide or poly(butylene succinate) normally induces hydrophilic natural polymers agglomeration during blending, resulting in phase-separated solutions [27,28].…”

Section: Introductionmentioning

confidence: 99%

Single-step, acid-based fabrication of homogeneous gelatin-polycaprolactone fibrillar scaffolds intended for skin tissue engineering

et al. 2020

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Blends of natural and synthetic polymers have recently attracted great attention as scaffolds for tissue engineering applications due to their favorable biological and mechanical properties. Nevertheless, phase-separation of blend components is an important challenge facing the development of electrospun homogeneous fibrillar natural-synthetic polymers scaffolds; phase-separation can produce significant detrimental effects for scaffolds fabricated by electrospinning. In the present study, blends of gelatin (Gel; natural polymer) and polycaprolactone (PCL; synthetic polymer), containing 30 and 45 wt% Gel, were prepared using acetic acid as a ‘green’ sole solvent to straightforwardly produce appropriate single-step Gel-PCL solutions for electrospinning. Miscibility of Gel and PCL in the scaffolds was assessed and the morphology, chemical composition and structural and solid-state properties of the scaffolds were thoroughly investigated. Results showed that the two polymers proved miscible under the single-step solution process used and that the electrospun scaffolds presented suitable properties for potential skin tissue engineering applications. Viability, metabolic activity and protein expression of human fibroblasts cultured on the Gel-PCL scaffolds were evaluated using LIVE/DEAD (calcein/ethidium homodimer), MTT-Formazan and immunocytochemistry assays, respectively. In vitro results showed that the electrospun Gel-PCL scaffolds enhanced cell viability and proliferation in comparison to PCL scaffolds. Furthermore, scaffolds allowed fibroblasts expression of extracellular matrix proteins, tropoelastin and collagen Type I, in a similar way to positive controls. Results indicated the feasibility of the single-step solution process used herein to obtain homogeneous electrospun Gel-PCL scaffolds with Gel content ≥30 wt% and potential properties to be used as scaffolds for skin tissue engineering applications for wound healing.

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Polyacrylamide (PAM)

Wiśniewska¹

2018

High Performance Polymers and Their Nanocomposites

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Preparation and study on miscibility, thermal behavior of biocompatible polymer blends of xanthan Gum-polyacrylamide

Cited by 8 publications

References 22 publications

Patient-friendly extemporaneous formulation of bisoprolol: application to stability and bioavailability studies

Patient-friendly extemporaneous formulation of bisoprolol: application to stability and bioavailability studies

Single-step, acid-based fabrication of homogeneous gelatin-polycaprolactone fibrillar scaffolds intended for skin tissue engineering

Polyacrylamide (PAM)

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