Preparation and structure analysis of non-covalent interactions mediated 2D-3D supramolecular adducts from 6-methylnicotinamide and carboxylic acids

Wu, Yujiu; Zhou, Jingxian; Jin, Shouwen; Liu, Hui; Shi, Chengzhe; Wang, Daqi

doi:10.1016/j.molstruc.2022.133135

Cited by 8 publications

(1 citation statement)

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“…Therefore, methods to reasonably design cocrystals and salts with ideal structural characteristics and the selection of functional groups contained in the compound is essential. Aromatic carboxylic acids are a kind of organic supramolecular structural unit that can form stable skeleton structures through directed non-covalent forces (mainly hydrogen bonds); hence, it has attracted extensive attention of researchers [32,33]. In general, carboxylic acid ligands promote the self-association of supramolecular homosynthons (composed of the same complementary functional groups).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structure Characterization of Three Pharmaceutical Compounds Based on Tinidazole

Chen

et al. 2023

Crystals

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Tinidazole (TNZ), a 5-nitroimidazole derivative, has received increasing attention due to its pharmacological activities in treatment for amebic and parasitic infections. In this paper, we synthesized three novel drug supramolecular compounds successfully based on TNZ. The three compounds discussed were formed by TNZ and 2,6-dihydroxybenzoic acid (2,6-DHBA), 4-methylsalicylic acid (4-MAC), and 5-chloro-2-hydroxybenzoic acid (5-C-2-HBA). The N-H···O and O-H···O hydrogen bonds and weak C-H···O hydrogen bonds are the primary intermolecular forces in the construction of the three compounds. Crystal structure analysis revealed that all the compounds exhibit three-dimensional frameworks consisting of non-covalent interactions. Furthermore, six primary synthons, Ⅰ R22 (8), Ⅱ R21(6), Ⅲ R22(12), Ⅳ R33(9), Ⅴ R22(12), Ⅵ R33(9), formed through various hydrogen bonds are found in the three compounds. Moreover, the resulting pharmaceutical supramolecular compounds show improved stability. Single-crystal X-ray diffraction analysis, infrared spectroscopy (IR), element analysis, and thermogravimetric analysis (TGA) are reported.

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Section: Introductionmentioning

confidence: 99%