Preparation and stability testing of a hydrogel for topical analgesia

Abstract

With the commercial availability of a cream (EMLA) containing a eutectic mixture of local anaesthetics, 2.5% (w/w) lidocaine and 2.5% (w/w) prilocaine, effective topical anaesthesia of the intact skin is possible without the need for subcutaneous injections or exposure to high concentrations of local anaesthetics. In our hospital a topical anaesthetic product was designed for the same purpose. The home-made product contains a eutectic mixture of a local anaesthetic (5% w/w) and l-menthol (1% w/w). Prilocaine was used as the local anaesthetic because it is known for its safety and its well investigated analgesic effects. The eutectic mixture of prilocaine and l-menthol was mixed with a carbopol hydrogel (1% w/w). Preliminary testing of this anaesthetic hydrogel in our hospital has yielded satisfactory results. The anaesthetic hydrogel was found to be stable after at least 3 months' storage at ambient temperature.

Three-dimensional axisymmetric flow-focusing device using stereolithography

“…Highly monodisperse hydrogel microbeads have many important applications in pharmacy (Nortier et al 1995), food coatings (Sanguansri et al 2006) and biomedical industries such as cell encapsulation (Jen et al 1996;Luca et al 2007) and drug delivery systems (Graham and Mcneill 1984). In cell encapsulation for tissue engineering and cell-based beads array systems, micro-sized monodisperse hydrogel beads are in demand since they facilitate handling and allow rapid exchange of nutrients into and waste out of these beads.…”

A comparison of the efficacy of topical application of Lignocaine Hydrochloride 5% gel and Bupivacaine Hydrochloride 5% gel for extraction of teeth

“…Ultimately, a very short clinically insignificant pain relief [10] is obtained following topical application. To overcome this problem of retaining the drug on the mucosa for a desired length of time, and to achieve adequate anesthesia [11], 5% lignocaine and bupivacaine gels were made with carbopol [12] which increases the mucoadhesion and helps in the stability of the mixture for longer period of time.…”

Preparation and assessment of ketamine hydrogels for prolonged transdermal anaesthesia

“…Transdermal anaesthesia is of potential benefit postoperatively, particularly in paediatric and elderly patients. Transdermal anaesthetic agents are available as a patch, film, gel, or cream [1][2][3].…”

“…Transdermal anaesthesia has been used for more than three decades in children following invasive procedures [1][2][3]. Transdermal anaesthetics must have a rapid onset of action with good efficacy at a low cost.…”

“…Transdermal anaesthetics must have a rapid onset of action with good efficacy at a low cost. Many studies have explored the transdermal administration of anaesthetic drugs in various forms that allow rapid absorption (irrespective of molecular weight and skin permeability) with consistent efficacy [2,3]. Various polymers such as polyglycolic acid, poly l-lactic acid, polylactic copolymer, chitosan (CTS), and poloxamerhave been investigated for the development of hydrogels.…”