Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming

Goimil, Leticia; Jaeger, Philip; Ardao, Inés; Gómez-Amoza, J.L.; Concheiro, Ángel; García‐González, Carlos A.

doi:10.1016/j.jcou.2017.12.012

Cited by 34 publications

(24 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the soaking time mainly affects the CO2 distribution along the polymer, resulting in heterogeneous structures when the soaking time is insufficient to achieve a saturation state [111]. Namely, the increase in the soaking time allows a greater gas dissolution in the polymer, which means more nucleation points that upon The operating temperature depletion associated with compressed CO 2 foaming makes possible the incorporation of thermolabile bioactive compounds such as drugs [97][98][99][100][101][102] and proteins (e.g., growth factors, enzymes) [96,[103][104][105][106][107], among others. Upon system depressurization, CO 2 exits the polymeric matrix, leading to a scaffold of controlled porosity.…”

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

“…The most accurate equipment to experimentally determine the CO 2 sorption in a polymer is the magnetic suspension balance, which is a contactless method that is able to weigh the sample under a wide range of pressures and temperatures [98,113]. the release of pressure would render scaffolds with higher cell densities and reduced pore diameters (Figure 9d-f) [112].…”

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

“…the release of pressure would render scaffolds with higher cell densities and reduced pore diameters (Figure 9d-f) [112]. The most accurate equipment to experimentally determine the CO2 sorption in a polymer is the magnetic suspension balance, which is a contactless method that is able to weigh the sample under a wide range of pressures and temperatures [98,113]. Supercritical CO2 foaming usually produces scaffolds with closed pores and low pore interconnectivity, being key parameters determining both the permeability and cellular infiltration capacity [114].…”

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

See 2 more Smart Citations

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

View full text Add to dashboard Cite

The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds in terms of efficiency and versatility. The principles of these solvent-free technologies (melt molding, 3D printing by fused deposition modeling, sintering of solid microspheres, gas foaming, and compressed CO2 and supercritical CO2-assisted foaming), a critical discussion of advantages and limitations, as well as selected examples for regenerative medicine purposes are herein presented.

show abstract

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

See 1 more Smart Citation

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

View full text Add to dashboard Cite

show abstract

“…Although diverse engineering groups established different types of implants for a broad range of applications, those implants can elicit body responses involving inflammatory processes, which may result in the formation of glial scars due to neural devices specifically [12,13,20,21]. One strategy to avoid immune responses consists of releasing an anti-inflammatory biomolecule (i.e., dexamethasone) in the vicinity of the implant [11,13,22,23]. Dexamethasone (Dx) is a synthetic glucocorticoid that reduces inflammation in the central nervous system, acting through glucocorticoid receptors found in most neurons and glial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Dexamethasone (Dx) is a synthetic glucocorticoid that reduces inflammation in the central nervous system, acting through glucocorticoid receptors found in most neurons and glial cells. Due to being locally delivered, the specificity and efficiency of dexamethasone means that only small amounts of the drug are required [13,22,[24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses

et al. 2020

View full text Add to dashboard Cite

Smart conductive materials are developed in regenerative medicine to promote a controlled release profile of charged bioactive agents in the vicinity of implants. The incorporation and the active electrochemical release of the charged compounds into the organic conductive coating is achieved due to its intrinsic electrical properties. The anti-inflammatory drug dexamethasone was added during the polymerization, and its subsequent release at therapeutic doses was reached by electrical stimulation. In this work, a Poly (3,4-ethylenedioxythiophene): κ-carrageenan: dexamethasone film was prepared, and κ-carrageenan was incorporated to keep the electrochemical and physical stability of the electroactive matrix. The presence of κ-carrageenan and dexamethasone in the conductive film was confirmed by µ-Raman spectroscopy and their effect in the topographic was studied using profilometry. The dexamethasone release process was evaluated by cyclic voltammetry and High-Resolution mass spectrometry. In conclusion, κ-carrageenan as a doping agent improves the electrical properties of the conductive layer allowing the release of dexamethasone at therapeutic levels by electrochemical stimulation, providing a stable system to be used in organic bioelectronics systems.

show abstract

Properties and morphology of polylactic acid composites reinforced by orientation aligned calcium carbonate whisker

Guo

Zou

Dai

et al. 2023

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this work, the polylactic acid (PLA)/calcium carbonate whisker (CCW) fibers was prepared by a simple solution spinning method. The PLA/CCW fiber was arranged in different stacking sequences into the laminated structure, and then was hot pressed to obtain the PLA/CCW composite plate with orientation aligned CCW. The presence of orientation aligned CCW significantly improved the flexural performance of composites. The flexural modulus of the unidirectional stacking PLA/CCW composite containing 20 wt% CCW was 7049 MPa, which was nearly twice of pure PLA. After the CCW were treated by silane coupling agent, the toughness of PLA/CCW composite can be enhanced due to the improvement of interfacial interaction between CCW and PLA. The effect of stacking sequence on the mechanical properties of composites was investigated. The 45° angel cross stacking PLA/CCW composite has higher tensile performance and moderate flexural performance compare with other composites. The PLA/CCW composites prepared in this work has good potential applications in the biomedical field due to its good mechanical and biodegradable properties.

show abstract

Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming

Cited by 34 publications

References 54 publications

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses

Properties and morphology of polylactic acid composites reinforced by orientation aligned calcium carbonate whisker

Contact Info

Product

Resources

About