Preparation and stability investigation of the inclusion complex of sulforaphane with hydroxypropyl-β-cyclodextrin

Improvement of Solubility and Antifungal Activity of a New Aminothiophene Derivative by Complexation with 2-Hydroxypropyl-β-cyclodextrin

“…The inner part of CD molecules is apolar due to the presence of glycosidic oxygens and methanetriyl protons, while its external surface is polar due to the presence of hydroxyl groups, which allow complexation with hydrophobic compounds improving its solubility. 8,9 Nowadays, more than 35 different drugs are marketed as solid or solution-based CD complex formulations, including alprostadil, meloxicam, nicotine, omeprazole, itraconazole, aripiprazole, and insulin. 10,11 Natural CDs have limited water solubility, which in turn negatively influences water solubility of the formed complex.…”

“…Furthermore, there are toxicological studies pointing out that HP-β-CD is well tolerated in animal models and humans by either oral or intravenous administration. 7,9,13 The present work was carried out with the aim to evaluate the formation of 6CN10:HP-β-CD complex to improve the aqueous solubility and consequently the antifungal activity of 6CN10. The prepared complexes were characterized by 1 H and 2D nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, thermogravimetric analysis (TGA), X-ray diffractometry (XRD) and scanning electron microscopy (SEM).…”

Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

“…Various techniques have been used to improve the solubility/dissolution rate of poorly water-soluble drugs, among which cyclodextrin (CD) complexation is of particular interest (Wu et al 2010;Hu et al 2012). The complexes with β-CD have been prepared by different methods such as kneading, coevaporation, physical mixture and freeze drying (Ruz et al 2012;George and Vasudevan 2012;Passos et al 2012;Qiu et al 2014).…”

The role of phytochemicals in modulating intrinsic human cellular defence processes

“…366 As such, broccoli-derived foods or supplements require the hydrolysis of the glucoraphanin precursor in the presence of the MYR enzyme; typically, this occurs when the fresh plant cell is ruptured or when a dry whole powder becomes moist. In short, SFN must be formed close to the time of ingestion.…”

“…The well-researched broccoli-derived ITC is sulforaphane (SFN) and it is this compound which appears to be responsible for the larger part of the plant's health-promoting and cancer-preventive properties beyond its nutrient content. 362,363,364 Whereas many plant-derived nutraceutical supplements contain extracts of the major identified bioactive compound(s), the intrinsic instability 365,366 of the naturally-occurring SFN molecule presents a challenge for which a manufacturing solution has yet to be found; SFN per se is simply not sufficiently stable to enable production as a supplement. Alternative means of addressing this challenge are discussed herein.…”