Preparation and Quality Control of 99mTc-Calciumgluconate

Abstract

A procedure for the labelling of lyophilised Sn-Ca-Gluconate by a 99mTc instant technique was developed. Paper and TLC chromatography and low-voltage electrophoresis were used for the determination of the labelling yield which reached between 95 to 98%. The biodistribution was followed in white (albino) rats. About 25 to 35% of the total activity of the compound was retained in the kidneys one hour after its i.v. injection.