Preparation and properties of nanodiamond/poly(lactic acid) composite nanofiber scaffolds

Cai, Ning; Dai, Qin; Wang, Zelong; Luo, Xiaogang; Xue, Yanan; Yu, Faquan

doi:10.1007/s12221-014-2544-2

Cited by 46 publications

(31 citation statements)

References 56 publications

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“…Although HP for native PLA scaffolds was around 0.38 ± 0.11%, after grafting with gelatin its HP value increased to 0.56 ± 0.13% in direct contact assay, and were considered as nonhemolytic. Meanwhile PLA/gelatin‐blended system obtained HP value (1.55 ± 0.22%) higher than that of pristine PLA and gelatin g ‐PLA system . The comparison of results of HP for all the scaffolds is displayed in Table .…”

Section: Resultsmentioning

confidence: 93%

Benign route for the modification and characterization of poly(lactic acid) (PLA) scaffolds for medicinal application

Alippilakkotte

Sreejith

2017

J of Applied Polymer Sci

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Scaffolds fabricated from polymers have imprinted its wide applicability in the field of tissue engineering. The surface of electrospun poly(lactic acid) (PLA) nanofibers was modified to improve their compatibility with living medium. PLA film were treated with alkali solution to introduce carboxyl groups on the surface followed by covalent grafting of gelatin using Xtal Fluoro-E as coupling agent. The gelatin g-PLA polymer synthesized via 'graft-onto' method exhibit fascinating properties as studied by contact angle measurement, fourier transformed infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, water vapor transmission rate(WVTR), swelling studies and differential scanning calorimetry. The fabricated gelatin g-PLA scaffolds were further characterized to conduct the study on hydrolytic degradation, and extent of biodegradation at ambient temperature. It was observed from the in-vitro analysis that the gelatin g-PLA nanofiber (with hemolytic percentage, 0.56 6 0.13%) was cytocompatible with fibroblast cell and does not impair cell growth. The WVTR obtained for the electrospun mat around 2900 6 100 g/m 2 . 24 h signifies the optimal moist environment required for tissue engineering especially wound healing. Notably, many of these strategies resulted in porous hydrophilic scaffolds with human cell growth and proliferation for medical applications of various types. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46056. INTRODCTIONPoly(L-lactic acid) (PLA) is one of the most important biodegradable, biocompatible, environment-friendly, and recyclable thermoplastic polyester with extensive biomedical applications. 1 However, due to the hydrophobic nature of the PLA, cell adhesion is not possible in a straight forward way. 2 The most convenient method to improve the cytocompatibility is by grafting PLA with some hydrophilic and bio-compatible components, such as chitosan, 3 gelatin, 4 alginate, 5 RGD peptide, 6 arginine, 7 lysine, PEG, 8 collagen and other extracellular matrix (ECM) proteins. In order to increase the cytocompatibility of PLA, modifications can be done by several processes such as polymerization grafting, 9 oxygen plasma modification, 10 hydrolysis, 11 entrapment, 12 aminolysis, 13 and so on. The employment of ECM proteins or RGD peptide for surface coating of PLA is one of the facile and favorable method to achieve cytocompatibility. Alternatively, the feasibility of swollen PLA surface entrapped with bio macro-molecules, such as chitosan, gelatin, and poly(L-lysine) increases when exposed to the solvent/non-solvent mixture, where most of the solvents for PLA are nonbiocompatible.Alkaline hydrolysis is one of the efficient and common pretreatment method to create active functional group on PLA backbone. 14 Most promising outcome has been established on treatment of the natural fibers with alkaline solution (e.g., with 2% sodium hydroxide aqueous solution). The improvement in the surface hydrophilicity can be confirmed by the decreasing contact angle of ...

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Section: Resultsmentioning

confidence: 93%

Benign route for the modification and characterization of poly(lactic acid) (PLA) scaffolds for medicinal application

Alippilakkotte

Sreejith

2017

J of Applied Polymer Sci

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“…Moreover, GO‐Ag/CG possessed the highest T D at 111.5 °C among the five specimens, which was even 9.3 °C larger than that of GO + Ag/CG (102.2 °C). It is known that the improvement of thermal stability of polymer is tightly correlated to good dispersion state of nanofillers . More significant improvement on CG by GO‐Ag nanocomposites than by the mixture of nonassociated GO and AgNPs suggests the decoration of AgNPs can promote the exfoliation and dispersion of GO sheets in the composite matrix.…”

Section: Resultsmentioning

confidence: 99%

“…The introduction of reinforcement agents is a popular way to enhance the mechanical properties of polymeric nanofibers. Different types of nanofillers such as graphene oxide (GO), nanodiamonds, carbon nanotube, and halloysite nanotube, have been used to fabricate composite nanofibers. Particularly, GO demonstrated the outstanding performance for reinforcing chitosan/gelatin (CS/GE) PEC nanofiber system.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of graphene oxide‐silver nanofillers on engineering performances of polyelectrolyte complex nanofiber membranes

Cai

Zeng

et al. 2018

J of Applied Polymer Sci

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The poor mechanical and antibacterial performance has become a big hurdle for extending the application of polyelectrolyte complex (PEC) nanofibers in various fields. In this study, chitosan/gelatin (CG) composite nanofiber system was used for portraying the synergistic enhancement of mechanical and antibacterial properties of PEC nanofiber membranes by inclusion of graphene oxide‐silver (GO‐Ag) nanofillers. In particular, the introduction of 1.5 wt % GO‐Ag has raised the elastic modulus and tensile strength of CG nanofiber membrane by 105% and 488%, respectively, which are partially attributed to the alleviated restacking of graphene sheets by the anchored AgNPs. Meanwhile, the diameters of inhibition zone against Escherichia coli and Staphylococcus aureus on LB‐agar plates induced by GO‐Ag/CG nanofiber membranes are increased by 80.5% and 50.1%, respectively, compared to that by CG membrane. The synergistic improvement of antimicrobial performance of GO‐Ag/CG may be related to the accumulation of microorganisms induced by GO. In summary, the incorporation of GO‐Ag composite nanofillers has emerged as an effective strategy for engineering PEC nanofiber membranes for potential applications in nanomedicine and tissue engineering. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46238.

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“…ND with a 2.4-fold increase in tensile strength, 1.6-fold enhancement in Young's modulus, the 1.4-fold elevation of elongation at break, and 4.8-fold growth of fracture toughness. These increments were the direct benefit from the effective interfacial adhesion between PLA and rigid ND particles and the good dispersion of NDs in the PLA matrix (Cai et al, 2014).…”

Section: Electrospinningmentioning

confidence: 99%

“…These increments were the direct benefit from the effective interfacial adhesion between PLA and rigid ND particles and the good dispersion of NDs in the PLA matrix(Cai et al, 2014).Medical grade ND has been used for electrospinning of chitosan/ bacterial cellulose solutions. They also found that 1 wt% ND concentration showed the highest matrix tensile properties and improved preosteoclast proliferation and differentiation.…”

mentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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Preparation and properties of nanodiamond/poly(lactic acid) composite nanofiber scaffolds

Cited by 46 publications

References 56 publications

Benign route for the modification and characterization of poly(lactic acid) (PLA) scaffolds for medicinal application

Benign route for the modification and characterization of poly(lactic acid) (PLA) scaffolds for medicinal application

Synergistic effect of graphene oxide‐silver nanofillers on engineering performances of polyelectrolyte complex nanofiber membranes

Nanodiamond in composite: Biomedical application

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