Preparation and properties of chitosan derivative/poly(vinyl alcohol) blend film crosslinked with glutaraldehyde

Yu, Qingxu; Song, Yanan; Shi, Xiaomei; Xu, Chunye; Bin, Yuezhen

doi:10.1016/j.carbpol.2010.12.006

“…Figure 4 A shows that the structure of the gelatin film was homogeneous, convex and continuous. The chitosan and gelatin/chitosan films were smooth and had compact structures, as shown in Figures 4 B and C. These observations agree with reports that the surface of chitosan films presents as a smooth, continuous and compact structure (Ghaffari, 2007;Yu et al, 2011). This indicates that the presence of gelatin hardly caused structural changes in the chitosan film when the chitosan/ gelatin blend ratio was 6:4.…”

Section: Semsupporting

confidence: 90%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2017

Braz. J. Pharm. Sci.

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The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.

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“…The chitosan and gelatin/chitosan films were smooth and had compact structures, as shown in Figures 4B and 4C. These observations agree with reports that the surface of chitosan films presents as a smooth, continuous and compact structure (Ghaffari et al, 2007;Yu et al, 2011). This indicates that the presence of gelatin hardly caused structural changes in the chitosan film when the chitosan/ gelatin blend ratio was 6:4.…”

Section: Semsupporting

confidence: 90%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2016

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/ gelatin complex film and a multilayer coating system. Uniterms: Chitosan/gelatin complex film/drugs coating. Chitosan/multilayer coating system/drugs coating. Drugs/delivery system/colon-targeted. Tablets/bilayer-coated.O objetivo desta pesquisa foi planejar um novo sistema de liberação de fármacos direcionado ao cólon, utilizando quitosana. Estudaram-se as propriedades dos filmes a fim de obter informações úteis sobre a aplicação desses filmes compósitos. Utilizaram-se os filmes compósitos em sistema de bicamada para investigar a sua viabilidade como materiais de revestimento. Estudos de resistência à tração, grau de intumescimento, solubilidade, grau de biodegradação, no infravermelho por transformada de Fourier (FTIR), de calorimetria diferencial de varredura (DSC) e de microscopia eletrônica de varredura (SEM) mostraram que o filme compósito se formou quando a quitosana e a gelatina reagiram entre si. Os resultados mostraram que a mistura de proporção ótima foi de 6:4 de quitosana:gelatina. Resultados da liberação do fármaco in vitro indicaram que o sistema de revestimento de Eudragit e bicamada de quitosana/gelatina impediu a liberação de fármaco em fluido intestinal simulado (SIF) e em fluido gástrico simulado (SGF). Entretanto, a liberação de fármaco do comprimido revestido em bicamada no SCF aumentou ao longo do tempo e o fármaco foi quase completamente liberado após 24 h. Em geral, se obteve a forma de liberação dirigida ao cólon, utilizando filme complexo de quitosana/gelatina e sistema de revestimento multicamada.Unitermos: Quitosana/filme de complexo de gelatina. Quitosana/sistema multicamadas de revestimento/ revestimento de fármacos. Fármacos/sistema de liberação/dirigido ao cólon. Comprimidos/revestidos com bicamada.

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“…Akan tetapi, sifat dasar kitosan yang rapuh dan hidroskopis masih menjadi kendala dalam aplikasi filtrasi, sehingga perlu dilakukan formulasi dan optimasi pada komposisi bahan dan proses pembuatan membran. Kitosan dapat dikombinasikan dengan Polyvynil Alcohol (PVA) dan Poly Ethylene Glikol (PEG) untuk membentuk membran kitosan yang hidrofobik dan kuat (Ariyaskul et al 2006;Hyder and Chen 2009;Bolto et al 2009;Zhu et al 2010;Yu et al 2011;Erizal et al 2013;Salehi and Madaeni 2014). Gugus amina pada kitosan akan bereaksi dengan gugus OH-dari PVA melalui ikatan hidrogen sehingga akan memperkuat sifat komposit membran (Riyanto, Suwandi, dan Permana 2010;Lusiana, Siswanta, and Hayashita 2013).…”

Section: Pendahuluanunclassified

Formulasi Komposisi Membran Kitosan Dan Optimalisasi Pengadukan Dalam Penurunan Kandungan Padatan Limbah Cair Kelapa Sawit

Wahyuni¹,

Siswanto²,

Putra³

2017

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Article history PVA (40:60, 45:55, 50:50, 55:45 and 60:40 (v/v)) and stirring speed (200 rpm and 250 rpm). Chitosan composite membrane was tested in a cross flow reactor system. The result showed that the highest rejection values of TSS and TDS generated by the membrane on the chitosan and PVA ratio of 50:50 (v:v) at stirring speed of 250 rpm were 96.84% and 97.23%, respectively. Keywords: Chitosan membrane, POME, Solid rejection, TSS, TDS Kata kunci: AbstrakMembran kitosan POME Penurunan padatan TSS TDS Limbah cair kelapa sawit (LCKS) atau yang lebih dikenal dengan POME merupakan limbah cair industri kelapa sawit dengan kandungan padatan yang tinggi. Filtrasi limbah dengan menggunakan membran kitosan telah diteliti dapat menurunkan nilai padatan pada limbah POME, namun hasil filtrasi masih belum memenuhi baku mutu. Oleh karena itu, perlu dilakukan pengembangan kualitas membran dengan cara formulasi dan optimasi proses pembuatan membran (komposisi dan kecepatan pengadukan). Penelitian ini bertujuan untuk mengetahui pengaruh komposisi dan kecepatan pengadukan terhadap kinerja membran dalam penurunan nilai padatan POME.

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Preparation and properties of chitosan derivative/poly(vinyl alcohol) blend film crosslinked with glutaraldehyde

Cited by 114 publications

References 20 publications

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Formulasi Komposisi Membran Kitosan Dan Optimalisasi Pengadukan Dalam Penurunan Kandungan Padatan Limbah Cair Kelapa Sawit

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