Preparation and properties of biocompatible polymer-grafted silica nanoparticle

Yokoyama, Ruriko; Suzuki, Seiko; Shirai, Kumi; Yamauchi, Takeshi; Tsubokawa, Norio; Tsuchimochi, Makoto

doi:10.1016/j.eurpolymj.2006.08.015

Cited by 68 publications

(47 citation statements)

References 24 publications

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“…Atom transfer radical polymerization (ATRP) also remains one of the most powerful, versatile, simplest, and least expensive polymerization techniques [17]. Not only does this feature offer ability to tailor the polymer coatings to possess a variety of compositions and functionality, but this feature may be important in biomedical applications to modify a biological polymer specifically for cellular interactions [18,19]. The basis of the ATRP technique is the reversible transfer of a halogen atom from a polymeric alkyl halide (R-X) to a transition metal complex (LMtn), generating an organic radical and a transition metal complex (LMtn+1X) with a higher oxidation state [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of different ligands on the controlled polymerization of monodisperse polystyrene nanospheres by atom transfer radical polymerization in an aqueous emulsion

Tian¹,

Hu²,

Miao³

et al. 2012

Express Polym. Lett.

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Abstract. Polystyrene nanospheres have been synthesized by atom transfer radical polymerization (ATRP) to control the molecular weight distribution in the aqueous system. The crucial factor in such a system is the ligand that adjusts the solubility of the catalyst in different phases to control the concentration of both the activator and the deactivator in reaction phase. The effect of different ligands including ethylenediamine, 1,10-phenanthroline (phen) and 4,4-dinonyl-2, 2-bipyridyl (dNbpy) on the catalytic solubility in the organic and aqueous phase has been investigated. The molecular weight distribution of polymer obtained in this way was analyzed by gel permeation chromatography (GPC). It showed that the obtained polymer particles presented a broad molecular weight distribution (polydispersity index 1.78) with ethylenediamine as the ligand, but the polymerization rate was high and conversion reached 96.8%. The molecular weight distribution of polystyrene was narrowest with dNbpy as ligand, but the conversion was lowest and only achieved to 69%. Possible reasons were the influence of the structure of three different ligands on the control of ATRP reaction. SEM and GPC indicated that the polystyrene nanospheres presented regular sphere with a diameter of about 120 nm and uniform molecular weight distribution, which possessed a significant potentials in drug carrier field.

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Section: Introductionmentioning

confidence: 99%

Effect of different ligands on the controlled polymerization of monodisperse polystyrene nanospheres by atom transfer radical polymerization in an aqueous emulsion

Tian¹,

Hu²,

Miao³

et al. 2012

Express Polym. Lett.

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“…4,4 0 -Azobis(4-cyanopentanoic acid) (ACPA) obtained from Wako Pure Chemical Co., Ltd. Japan was recrystallized from methanol and dried in vacuo at room temperature. Tolylene 2,4-diisocyanate (TDI) and dimethyl sulfoxide (DMSO) were distilled before use.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] For example, we have reported that biocompatible polymer-grafted nano-sized silica surface shows antithrombus characteristic. 4 In our previous work, we have reported the radical grafting of various vinyl monomers onto nano-sized silica 5 and carbon black 6 initiated by surface radicals formed by thermal decomposition of azo groups previously introduced onto the surface. We have also reported that the system consisting of Mo(CO) 6 and surface trichloroacetyl groups on the nano-sized materials, such as silica 7 and vapor grown carbon fiber (VGCF), 8 has an ability to initiate the radical polymerization of various vinyl monomers to give the corresponding polymer-grafted silica and VGCF.…”

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confidence: 99%

Preparation of Antibacterial Polymer-grafted Nano-sized Silica and Surface Properties of Silicone Rubber Filled with the Silica

Yamashita

Takeuchi

Kikuchi

et al. 2006

Polym J

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ABSTRACT:Antibacterial polymer was grafted onto nano-sized silica surface and the surface properties of silicone rubber filled with the silica were investigated. The grafting of antibacterial polymer was carried out by two-step reactions as follows. Poly(p-styrene sodium sulfate) (poly(St-SO 3 À Na þ )) was successfully grafted onto nano-sized silica surface by the radical polymerization of St-SO 3 À Na þ initiated by the system consisting of trichloroacetyl groups on the silica surface and Mo(CO) 6 : trichloroacetyl groups were introduced onto the silica surface by the reaction of amino groups with trichloroacetyl isocyanate. The percentage of poly(St-SO 3 À Na þ ) grafting increased with progress of the polymerization and reached about 30%. The poly(St-SO 3 À Na þ )-grafted silica was treated with tributyltetradecylphosphonium chloride (Bu 3

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“…15 Silica gel filler is a stable and safe material that has a wide surface area and the ability to adsorb various materials. 3-Aminopropyl silica gel (SiO 2 -NH 2 ) 16,17 can immobilize functional groups through a covalent bond.…”

Section: Introductionmentioning

confidence: 99%

Development of acyl-bonded aminopropyl silica gel fillers with low interfacial adhesion energy in a polystyrene matrix

Senda¹,

Matsumoto

Hidaka

et al. 2010

Polym J

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To develop fillers that adhere closely to a matrix polymer and reduce the glass transition temperature (T g ) of filler/polymer composites, N-acyl-3-aminopropyl silica gel fillers (1) were prepared by the reaction of 3-aminopropyl silica gel (SiO 2 -NH 2 ) and succinimidyl alkanoate (2) by controlling the amount and length of alkyl chains. The surface tension (c) of 1 was measured by the wicking method. The interfacial adhesion energy (W) of composites (1/PS) between 1 and polystyrene (PS) was calculated using the dispersive component (c D ) and the polar component (c P ) of c, according to the Equation) where subscripts m and f indicate matrix and filler, respectively. The W values of 1/PS composites were considerably smaller than those of the SiO 2 -NH 2 /PS composite. A good correlation between W and T g showed that the introduction of acyl groups on SiO 2 was effective for the enhancement of adhesion between 1 and the matrix polymer. Moreover, it was confirmed that the addition of less than 30 wt% of 1 to PS did not affect the tensile strength of composites. Keywords: adhesion energy; aminopropyl silica gel; glass transition temperature; interface energy; surface tension; tensile strength INTRODUCTION Modification of polymers with fillers is widely used to enhance the performance of polymers. 1,2 Inorganic materials such as talc, 3 calcium carbonate, 4,5 glass, 6,7 silica, 8,9 alumina, 10 zeolite 11-13 and wollastonite 14 have been widely used as fillers to improve mechanical performance such as the tensile strength and elongation strength of polymers. To enhance adhesion between inorganic fillers and the polymer matrix, organic additives such as maleic anhydride, carboxylic acids and silane-coupling reagents are mixed with the polymer. 4 However, problems such as the dispersibility of organic additives in the polymer, the increase in glass transition temperatures (T g ) and the elution of organic additives remain in the manufacturing process.Recently, alkyl group-bonded zeolite 12 and wollastonite 14 fillers have been prepared to prevent the elution of organic additives from the polymer and to improve the handling of organic additives in the manufacturing process. 15 Silica gel filler is a stable and safe material that has a wide surface area and the ability to adsorb various materials. 3-Aminopropyl silica gel (SiO 2 -NH 2 ) 16,17 can immobilize functional groups through a covalent bond. To develop a high-performance filler that achieves higher adhesion and a lower T g of filler/polymer composites, the surface tension of the acyl-bonded SiO 2 -NH 2 filler (1) can be modified by controlling the amount and length of alkyl chains (Scheme 1).

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Preparation and properties of biocompatible polymer-grafted silica nanoparticle

Cited by 68 publications

References 24 publications

Effect of different ligands on the controlled polymerization of monodisperse polystyrene nanospheres by atom transfer radical polymerization in an aqueous emulsion

Effect of different ligands on the controlled polymerization of monodisperse polystyrene nanospheres by atom transfer radical polymerization in an aqueous emulsion

Preparation of Antibacterial Polymer-grafted Nano-sized Silica and Surface Properties of Silicone Rubber Filled with the Silica

Development of acyl-bonded aminopropyl silica gel fillers with low interfacial adhesion energy in a polystyrene matrix

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