Preparation and Properties Evaluation of Chitosan/Alginate Hydrogels in Drug Controlled Release

Abstract

Chitosan is the deacetylated derivative of chitin 1-5 , the most abundant natural polymer on earth after cellulose 6-8 , obtained from crustaceans 9-12 , such as shrimps, squids and crabs. Chitosan is the only basic polysaccharide in nature. It is greatly dominant to be used as a drug carrier due to the non-toxicity 13. Chitosan with good biocompatibility and biodegradation has widely application in many fields, such as wastewater treatment 14-16 , medicine, food, drug, environmental protection, light industry and agriculture 16-22. Sodium alginate widely exists in all kinds of natural polymer in the brown seaweed, can form simple gel with multivalent cations under mild conditions and the gel is non-toxic and suitable for embedding materials as a drug. This research selects chitosan and sodium alginate as the research object and the effect of crosslinking agent, pH value on swelling rate are studied and the effects of the performance of drug release are also investigated. EXPERIMENTAL Chitosan and sodium alginate (Deacelation degree 80 %) were purchased from Fuda Chemical Co. in China. Glutaraldehyde (GA, 50 wt % in water) and glacial acetic acid were purchased from Across, Morris Plane, NJ; Bovine serum albumin; buffer solution (pH=1.70, 4, 7.4, 9.18). All commercially solvents and reagents were used without further purification. All other chemicals were of analytical grade.

Preparation, bioactivity and mechanism of nano-hydroxyapatite/sodium alginate/chitosan bone repair material

“…In the FT-IR spectra of the n-HA/SAL/CS composite, the 568 cm -1 and 607 cm -1 peaks were the bending vibrations of PO 4 3- , 1,040 cm -1 was the asymmetric stretching vibration absorption peak of P-O (16), 1,383 cm -1 was probably the NO 3 − absorption peak that remained in the system, 1,640 cm -1 was the O-H stretching vibration of liquid water, 1,552 cm -1 represented the correlation absorption peak of secondary amide in the composite. Interestingly, the COO − peak of SAL and the NH 2 − vibration peak of CS disappeared, indicating that the SAL COO − crosslinked with the CS NH 2 − (17). Meanwhile, the OH − vibration peak of SAL and CS disappeared, as a hydrogen bond may be formed between the OH − and PO 4 3- .…”