Preparation and preliminary biological evaluation of 177Lu‐labeled GluDTPA‐cyclo(RGDfK) for integrin ανβ3 receptor‐positive tumor targeting

Kim, Jin Hwan; Lim, Jae-Cheong; Yun, Ki-Cheol; Choi, Sang-Jin; Hong, Young-Don

doi:10.1002/jlcr.1944

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…When a suspension of nano-sized praseodymium oxide particles was neutron irradiated the [Pr 141 (n,g)Pr 142 ] reaction lead to the formation of a radio-praseodymium colloid 163 which could be used therapeutically in nuclear medicine. For diagnosis, however, lutecium-177 is more useful and has recently been incorporated 164 into a radiopharmaceutical by a bifunctional chelator based on diethylenetriaminepentaacetic acid.…”

Section: Technetium (Tc 99m )mentioning

confidence: 99%

Radiochemistry

Urch

2013

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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In this year's review of recent progress in radiochemistry, new radiochemical methods for isotope production, advances in labelling procedures, radioactive isotopes in the environment and miscellaneous topics of radiochemical interest, will be covered but not radiation chemistry, neutron activation analysis and the chemistry of elements that happen to be radioactive. HighlightsThe incorporation of radioisotopes into, sometimes onto, nanoparticles, is becoming increasingly important in nuclear medicine, for therapy and also in diagnosis (ref. 108, 109, 148, 149, 153 and 261-264). Another important piece of work was the use of density functional theory to predict the properties and behaviour of a labelled molecule (ref. 130). General introductionIt is with great sadness that the death of Michael J. Welch in May of 2012 must be recorded. He it was who brought radiochemistry to the medical world, who demonstrated, to a sceptical audience, the potential that radioactive molecules had, when combined with tomography, for diagnosis and tumour location. For forty years he ceaselessly developed nuclear medicine, extending its range to more and more positron emitting isotopes and developing new chemical ways of incorporating them into increasingly complex bio-molecules, 'radiopharmaceuticals'.No new books on radiochemistry in 2012, but a review 1 of the discovery of artificial radioactivity and the report 2 of a conference on the synthesis and applications of labelled compounds have been published. Other conferences have been more focused on specific aspects of the preparation and uses of radioactive compounds, for medical diagnosis and therapy, 3 for autoradiography 4 and to study drug metabolism. 5 A history of the use of radio-iodine has published 6 and the design of bifunctional chelating molecules, 7,8 which can both encapsulate a radioactive atom and join benignly (one hopes so) to a protein or other bio-molecule, reviewed.

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Section: Technetium (Tc 99m )mentioning

confidence: 99%