Preparation and Physicochemical Characterization of Solid Dispersion of Aceclofenac Formulated by Solvent Evaporation Method

Abstract

Aceclofenac is an orally administered nonsteroidal anti inflammatory drug for the treatment associated with a variety of pain and rheumatoid arthritis conditions 1,2. These are most frequently prescribed drug worldwide and have been have been categories as 'over the counter' drug as well as consumed on non-prescription basis. But the major drawback associated is NSAID toxicity mainly targeted to gastro intestinal tract which can be fatal due to drug-induced toxicity. Though several cases have been reported yet management of this fatal problem has under gone little changes over past 50 years. In Indian context NSAIDs are among the most common drugs responsible for adverse drug