Preparation and Physicochemical Characterization of Glyceryl Monoolein Bearing Cubosomes to Improve Vitamin E delivery into the Skin: A Proposal for Skin Cancer Prevention

Salomao, Maria Julia Azarite; Praça, Fabíola Silva Garcia; Peh, Hong Yong; Foloni, Ana Rafaela; Silva, Daiana Alves da; Carvalho, Beatriz Monteiro de; Bentley, Maria Vitória Lopes Badra; Medina, Wanessa Silva Garcia

doi:10.2174/2210303108666180629150348

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…86 Cubosomes can improve the delivery of hydrophobic bioactive such as vitamin E into the deeper layers of skin. 78 At the same time, cubosomes do not induce skin irritation. Owing to these advantages, cubosomes have attracted great interest for the treatment of skin infections.…”

Section: ■ Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

“…Cubosomes had a higher encapsulation efficiency due to the deeper penetration of curcumin into the hydrophobic region. Cubosomes can also increase the storage stability and sustain the release of bioactive compounds, such as vitamin E and curcumin . Another advantage is that cubosomes are able to closely contact with intestinal cell membrane and favor the entrapment of bioactives into the mixed micelles that are formed by the digestion of cubosomes in gastrointestinal tract .…”

Section: Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

“…It has been shown that cubosomal encapsulation can enhance the skin permeation of water-soluble extract of Korean barberry by two times . Cubosomes can improve the delivery of hydrophobic bioactive such as vitamin E into the deeper layers of skin . At the same time, cubosomes do not induce skin irritation.…”

Section: Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

See 2 more Smart Citations

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Tan

Hosseini

Jafari

2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Cubosomes and hexosomes are nanostructured liquid crystalline particles, known as biocompatible nanocarriers for drug delivery. In recent years, there has been good interest in using cubosomes and hexosomes for the delivery of bioactive compounds in functional foods. These systems feature thermodynamic stability, encapsulate both hydrophobic and hydrophilic substances, and have a high tolerance to environmental stresses and potential for controlled release. This review outlines the recent advances in cubosomes and hexosomes in the food industry, focusing on their structure, composition, formation mechanisms, and factors influencing phase transformation between cubosomes and hexosomes. The potential applications especially for the bioactive delivery are presented. The integration of cubosomes and hexosomes with other emerging encapsulation technologies such as surface coating, gelation, and incorporation of polymers are also discussed.

show abstract

Section: ■ Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

Section: Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

Section: Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Tan

Hosseini

Jafari

2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Cubosomes: A Boon for Cosmeceuticals and Topical Drug Delivery

CHANDRAKALA

2022

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Cubosomes are the nanoparticles of bicontinuous, lyotropic cubic phases, comprised of curved lipid bilayers organized into a three-dimensional honeycomb (cavernous) like structures separating two internal aqueous channels and large interfacial area. Cubic phases are optically isotropic, very viscous, and solid-like (crystalline) with cubic crystallographic symmetry. They can encapsulate hydrophilic, hydrophobic and amphiphilic drug substances, which are able to target and control the release of the bioactive agent. The cosmetic industry has made progress in the development of products to overcome skin as a barrier and deliver the actives through the skin effectively. Drug incorporated cubosomes shows some unique advantageous like, protection from chemical and physiological degradation, in vivo drug release in a controlled manner and improving the bioavailability of drug while reducing the side effect. Cubosomes are pharmacologically inactive, non-irritant, non-toxic, effective, and cosmetically acceptable. Topical drug delivery can deliver drugs selectively to the specific site; this avoids fluctuations of drug levels and improves patient compliance and suitable local and systemic therapeutic effects. Cubosomal topical drug formulation shows outstanding potential advantages for their controlled and sustained drug delivery. This review article mainly focuses on cosmetic and topical applications of cubosomes.

show abstract

Preparation and Physicochemical Characterization of Glyceryl Monoolein Bearing Cubosomes to Improve Vitamin E delivery into the Skin: A Proposal for Skin Cancer Prevention

Cited by 2 publications

References 0 publications

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Cubosomes: A Boon for Cosmeceuticals and Topical Drug Delivery

Contact Info

Product

Resources

About