Preparation and pharmacokinetic and pharmacodynamic evaluation of hydroxy propyl cellulose-ethyl cellulose microcapsules containing piretanide.

Tsujiyama, Tsuyoshi; Suzuki, N.; Kawata, Masakazu; Uchida, Tatsuo; Goto, Shigeru

doi:10.1248/bpb1978.12.311

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Most applications of co-wall materials are by solvent evaporation, spray coating, and tablet pharmaceutics (Chang et al 1986, Huang and Ghebre-Sellassie 1989, Tsujiyama et al 1989, Chueh et al 1995, Giunchedi et al 1996. The non-solvent addition phase-separation method is little used.…”

Section: Introductionmentioning

confidence: 99%

The preparation and drug-release behaviour of CTA/EC and PMS/EC composite microcapsules

Tsai

Tien²,

Chen³

2000

Journal of Microencapsulation

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A cellulose triacetate (CTA) and three different molecular weights of poly(alpha-methyl styrene) (PMS) were used as co-wall materials to prepare composite microcapsules with ethylcellulose (EC). A non-solvent-addition phase-separation method was used. The core material was theophylline (TH) and the solvent-non-solvent pair was dichloromethane-n-hexane, and the drug-release rates of the microcapsules prepared from these two types of co-wall materials were compared. The effects of their phase-separation range on the properties of the microcapsules, such as particle size, release rate and the morphology of the microcapsules are also discussed. The release rate of microcapsules was also affected by the compatibility of the co-wall materials and the EC. The dissolution studies indicated that the drug-release time of CTA/EC and PMS/EC composite microcapsules was sustained to 10 and 3.5 times, respectively, in comparison with that for pure EC microcapsules.

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Section: Introductionmentioning

confidence: 99%

The preparation and drug-release behaviour of CTA/EC and PMS/EC composite microcapsules

Tsai

Tien²,

Chen³

2000

Journal of Microencapsulation

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Evaluation of microcapsules. Part XXVII. Pharmacological evaluation of hydroxypropylcellulose-ethylcellulose microcapsules containing piretanide.

Tsujiyama¹,

Suzuki²,

Kuriki³

et al. 1990

Journal of Pharmacobio-Dynamics

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Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: Techniques used to make microcapsules

Rogers

Wallick

2011

Drug Development and Industrial Pharmacy

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This three-part review has been developed following the evaluation of literature where ethylcellulose, methylcellulose or hypromellose was used to make microcapsules. Parts 1 and 3 of the review are published as separate papers. Part 1 covers the various materials used to formulate microcapsules, and Part 3 covers the various end-use applications for microcapsules. In the current paper, Part 2 covers the techniques used to make microcapsules. Examples of techniques to be covered include temperature-induced phase separation, emulsion solvent evaporation, solvent evaporation, film coating, nonsolvent addition and spray drying. It is hoped that formulators can use Part 2 to understand how to formulate microcapsules using these encapsulating polymers. SciFinder was utilized to perform the literature search. SciFinder leverages literature databases, such as Chemical Abstracts Service Registry and Medline. A total of 379 references were identified during the review. The need for a three-part review reflects the extensive amount of literature identified concerning these three encapsulating polymers.

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Preparation and pharmacokinetic and pharmacodynamic evaluation of hydroxy propyl cellulose-ethyl cellulose microcapsules containing piretanide.

Cited by 4 publications

References 11 publications

The preparation and drug-release behaviour of CTA/EC and PMS/EC composite microcapsules

The preparation and drug-release behaviour of CTA/EC and PMS/EC composite microcapsules

Evaluation of microcapsules. Part XXVII. Pharmacological evaluation of hydroxypropylcellulose-ethylcellulose microcapsules containing piretanide.

Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: Techniques used to make microcapsules

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