Preparation and pharmaceutical evaluation of Mucoadhesive Buccal film extracts of petroselinum for pharyngitis symptoms

Abstract

Background: Recently, the mucosa has attracted attention due to its large arteries and high permeability for drug delivery. Due to the anti-inflammatory effect of parsley and easy access to this plant in Iran and the fact that the adhesive mucosa film is a new method with high performance and efficiency of drug transfer, this study was done to evaluate the effect of this plant on the pharyngitis by preparing an oral adhesive mucus film from parsley plant extract and then evaluating its pharmacological properties. Materials and methods: Fast release films of parsley were made using hydroxypropyl methyl cellulosopropinyl alcohol polymers and the use of glycerin as plasticizer and casting method. Finally, the films are analyzed in terms of thickness, uniformity, amount of drug released and disintegration time with SPSS20 software. Results: No bubbles, cracks, creases or wrinkles were seen in any of the films made of HPMC and PVA polymers. The difference in thickness measured in all films was less than 5%, and the thickness of the films was the same. Therefore, the drug introduced into the formulations has been spread evenly everywhere. No trace of the film remained in the mouth and the patients had good compliance. Conclusion: Due to the rapid dissolution of the film, rapid release of the drug, ease of use and the appropriate effects of parsley in preventing inflammation, this formulation can be used for the elderly, children and those who have difficulty swallowing. Another advantage of this method is that it can reduce the metabolism of the drug in the first hepatic passage. As a result, this formulation is a good option for treating symptoms of pharyngitis.

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

“…Nagai also discovered that using a mucoadhesive polymer enhanced the absorption of peptides when administered nasally [201]. There has been a lot of pioneering work in this field, such as the development of mucoadhesive creams based on poly(acrylic acid) (PAAc) [202] and poly(methyl methacrylate) [203]. The majority of early research on mucoadhesion was done with traditional polymers in the form of tablets [204], powders [205,206], or films [207].…”