Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design

Moolakkadath, Thasleem; Aqil, Mohd.; Ahad, Abdul; Imam, Syed Sarim; Praveen, Arshiya; Sultana, Yasmin; Mujeeb, Mohd

doi:10.1016/j.ijpharm.2020.119125

Cited by 44 publications

(26 citation statements)

References 41 publications

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“…Furthermore, the insignicant lack of t value (p if > 0.05) highlights the adequacy of all response surfaces. [18][19][20] 3.1.2 Effect of independent variables on particle size and encapsulation efficiency. The effect of each independent variable on particle size is described by eqn (6) and shown in the corresponding 3D response surface plots (Fig.…”

Section: Resultsmentioning

confidence: 99%

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Wang

Wan

et al. 2021

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Wang

Wan

et al. 2021

RSC Adv.

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“…The results underlined that the composition of the vesicles and the addition of specific additives can positively affect the effectiveness of the payloads, even if for each bioactive or phytocomplex, an ad hoc formulation is required [ 35 , 64 , 65 ]. Previous works strengthened the positive effect of glycerosomes on promoting the accumulation of bioactives in the different skin strata, mainly because of the moisturizing effect of glycerol, which is able to modify the ordered structure of the stratum corneum and favor the passage of bioactives [ 66 ]. They have been used to deliver several natural molecules, extracts, and oils in the skin, providing an enhancement of the local bioavailability of the payload in comparison with liposomes [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

et al. 2020

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An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index ≤ 0.30), and their zeta potential was highly negative (~−45 mV). The vesicle dispersions maintained unchanged characteristics during 60 days of storage, were highly biocompatible, and were able to protect keratinocytes against damages due to oxidative stress induced by treating them with hydrogen peroxide. Vesicles were also capable of promoting cell proliferation and migration in vitro by means of a scratch wound assay. The results confirmed the fruitful delivery of the extract of H. scruglii in glycerosomes modified with glucidex and gelatin and their promising ability for skin protection and treatment.

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“…The final dispersion is then homogenized by ultrasonication. In other studies, the drug and the lipids are dissolved in the organic solvent to form a drug-containing thin layer [40,65].…”

Section: Preparation Of the Various Types Of Phospholipid Vesicles Fomentioning

confidence: 99%

“…The authors explained these structural changes in the skin were caused by lipid disruption and reorientation and increased fluidity of SC lipids. It was hypothesized that glycerol present in glycerosomes induced hydration of the skin and thereby enhanced the fluidity of the lipid bilayer by interacting with the polar head groups of the lipids for easy diffusion of the formulation [65].…”

Section: Mechanism Of Action Of Phospholipid Nanovesicles For Enhancementioning

confidence: 99%

Phospholipid Vesicles for Dermal/Transdermal and Nasal Administration of Active Molecules: The Effect of Surfactants and Alcohols on the Fluidity of Their Lipid Bilayers and Penetration Enhancement Properties

Natsheh

Touítou

2020

Molecules

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This is a comprehensive review on the use of phospholipid nanovesicles for dermal/transdermal and nasal drug administration. Phospholipid-based vesicular carriers have been widely investigated for enhanced drug delivery via dermal/transdermal routes. Classic phospholipid vesicles, liposomes, do not penetrate the deep layers of the skin, but remain confined to the upper stratum corneum. The literature describes several approaches with the aim of altering the properties of these vesicles to improve their penetration properties. Transfersomes and ethosomes are the most investigated penetration-enhancing phospholipid nanovesicles, obtained by the incorporation of surfactant edge activators and high concentrations of ethanol, respectively. These two types of vesicles differ in terms of their structure, characteristics, mechanism of action and mode of application on the skin. Edge activators contribute to the deformability and elasticity of transfersomes, enabling them to penetrate through pores much smaller than their own size. The ethanol high concentration in ethosomes generates a soft vesicle by fluidizing the phospholipid bilayers, allowing the vesicle to penetrate deeper into the skin. Glycerosomes and transethosomes, phospholipid vesicles containing glycerol or a mixture of ethanol and edge activators, respectively, are also covered. This review discusses the effects of edge activators, ethanol and glycerol on the phospholipid vesicle, emphasizing the differences between a soft and an elastic nanovesicle, and presents their different preparation methods. To date, these differences have not been comparatively discussed. The review presents a large number of active molecules incorporated in these carriers and investigated in vitro, in vivo or in clinical human tests.

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Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design

Cited by 44 publications

References 41 publications

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress

Phospholipid Vesicles for Dermal/Transdermal and Nasal Administration of Active Molecules: The Effect of Surfactants and Alcohols on the Fluidity of Their Lipid Bilayers and Penetration Enhancement Properties

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