Preparation and mechanical properties of poly(chitosan‐g‐DL‐lactic acid) fibrous mesh scaffolds

Abstract

DL‐lactic acid was grafted onto chitosan to produce poly(chitosan‐g‐DL‐lactic acid)(PCLA) without using a catalyst. These PCLAs were then spun into filaments and further fabricated into fibrous mesh scaffolds using an improved wet‐spinning technique. The diameter of filaments in different scaffolds could vary from a few micrometers to several tens of micrometers. The scaffolds exhibited various pore sizes ranging from about 20 µm to more than 200 µm and different porosities up to 80%. The several main processing conditions were optimized for obtaining the desired scaffolds with well‐controlled structures. The tensile and compressive mechanical properties of the mesh scaffolds in both dry and hydrated states were mainly examined. Significantly improved tensile strength and modulus, enhanced compressive modulus, and stress as well as the dimensional stability for these mesh scaffolds in their hydrated state were observed. Copyright © 2007 John Wiley & Sons, Ltd.

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

“…This curve is composed of a linear region, a flat region, and a densified region. 35,36 The linear elastic region (0 to 10% strain) represents the linear elastic deformation of the porous PPF- co -PLLA samples. The flat region (10 to 35% strain) was the plateau region of deformation at larger strain.…”

Chitosan–polycaprolactone copolymer microspheres for transforming growth factor-β1 delivery

“…The PCL side chains in CPCs could turn inward and aggregate together inside the microspheres as close as possible while the chitosan chains would stretch outward during the preparation of CPC microspheres by virtue of a water-based solvent, which is somewhat similar to the case of polylactide-chitosan copolymers [30]. The hydrophobic domains built by PCL side chains would thus prevent water from penetrating into microspheres and endue the microspheres with smaller swelling indexes and lower swelling rates, depending on the PCL content in CPCs.…”

Effect of porogen on the physico-chemical properties and degradation performance of PLGA scaffolds

“…The density and porosity values of the PLGA polymer scaffolds were measured by a modified liquid displacement method [22]: ethanol was chosen as the displacement liquid because it penetrated easily into the pores, it was a PLGA non-solvent and it did not induce shrinkage or swelling of polymer.…”