Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents

Pan, Changjiang; Tang, Jinjin; Weng, Yajun; Jin, Wang; Huang, Nan

doi:10.1016/j.colsurfb.2009.05.016

Cited by 31 publications

(13 citation statements)

References 29 publications

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“…1,2 In particular, polymer based coatings can serve as drug delivery platforms, releasing biomolecules (antibiotics, growth factors, proteins, peptides, genes) preloaded into the coating matrix, to convert conventional implants into biologically active components. 3,4 In comparison with conventional oral or injectable therapies usually associated with side effects, such coating systems should be able to release drug molecules locally and in a controlled manner for prolonged periods. 3,5 Local drug release provides the possibility of an efficient dosage at the defect site while avoiding undesired systemic effects.…”

Section: Introductionmentioning

confidence: 99%

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Chen

Yao

et al. 2016

J. Mater. Chem. B

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The development of drug delivery coating systems for local and long-term drug release is gaining increasing interest especially to functionalize bioinert implants with osseointegration and antibacterial properties. In this study, a biodegradable drug delivery coating platform consisting of drug-loaded PHBV microspheres embedded in an alginate-PVA matrix was fabricated by a one-step electrophoretic deposition (EPD) process. Layer by layer (LbL) deposition was exploited to generate chitosan-alginate multilayers on the EPD-produced coating to enlarge the diffusional barrier around the microspheres for controlled drug release. Daidzein, selected as a model drug due to its anti-osteoporosis properties, was pre-encapsulated in PHBV microspheres. The parameters for microsphere fabrication were optimized by an orthogonal design approach. The loading efficiency of daidzein in both the microspheres and in the deposited coatings was adjusted by varying the processing parameters during microsphere fabrication and the EPD process. The degradation of the deposited multilayers was investigated in PBS for up to 14 days. The degradation rate, surface roughness and wettability, as well as adhesion strength of the coatings during degradation were evaluated by applying a range of techniques. A controlled and sustained daidzein release was detected from both free microspheres and microsphere-containing coatings. Finally cytotoxicity and stimulatory effects of daidzein or daidzein-loaded coatings, on both MC3T3-E1 and RAW264.7 cell lines, were studied to validate the potential of the developed coatings for orthopedic applications.

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Section: Introductionmentioning

confidence: 99%

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Chen

Yao

et al. 2016

J. Mater. Chem. B

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“…Even though the amounts of drug incorporated are commonly very small, violation of sink conditions may occur since the media volumes are usually low as well and the drugs are typically very poorly soluble. As reported by Pan et al [63] it may be speculated that nearly constant drug release per sampling point may in some cases result from the applied sampling procedure in combination with the possible violation of sink conditions rather than from the controlled release of the drug substance. Due to the analytical limitations, media volumes of 1-15 ml are often used, the media is completely removed for analysis and fresh media is supplied at every sampling time [46,53,[59][60][61][62].…”

Section: Mediamentioning

confidence: 88%

In Vitro Dissolution Testing of Drug-Eluting Stents

Seidlitz¹,

Nagel²,

Semmling³

et al. 2013

Current Pharmaceutical Biotechnology

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Drug-eluting stents (DES) have revolutionized the treatment of coronary artery blockage by tremendously reducing the rate of in-stent restenosis and the necessity of repeat revascularization compared to bare-metal stents. They are also gaining increasing importance in other medical fields such as the treatment of certain localized tumors and in glaucoma therapy. DES generally contain most potent drugs, e.g. immunosuppressants or cytostatics, which are supposed to be released in a well controlled manner over time spans which are chosen according to disease progression. Typically, this means that fairly small amounts of drug are released over long periods of time. Therefore, quantification of in vivo plasma levels is often not feasible. Due to this limitation and the fact that tissue levels cannot be determined in humans, in vitro dissolution testing is one of the most powerful tools to gain insight into the release behaviour of DES. This article focuses on the methods for in vitro dissolution testing of DES which are available up to date and highlights the specific characteristics of drug release from stents arising from the composition and the in vivo localization of the dosage form.

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“…A stent is an expandable tubular device [1,2] able to scaffold the vessel and to maintain the perviety of the artery after balloon angioplasty [3,4], in order to restore the normal flow conditions [5] in arteries clogged up by the build-up of fatty substances [6].…”

Section: Introductionmentioning

confidence: 99%

In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents

Gagliardi

2012

Materials Science and Engineering: C

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Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents

Cited by 31 publications

References 29 publications

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

In Vitro Dissolution Testing of Drug-Eluting Stents

In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents

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