Preparation and in vitro investigation on bioactivity of magnesia-contained bioactive glasses

Arepalli, Sampath Kumar; Tripathi, Himanshu; Manna, Partha Pratim; Pankaj, Pankaj; Krishnamurthy, Sairam; Patne, Shashikant C. U.; Pyare, Ram; Singh, Shailendra

doi:10.1007/s41779-018-0220-5

Cited by 10 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The coexistence of sodium and magnesium in SNCMP glass has dual importance since it enhanced bioactivity and hindered the crystallisation of the Na2Ca2Si3O9 phase at 600°C, which would be beneficial for sintering at higher temperature. Arepalli et al reported that bioactive glasses in the system (46.10-x)%SiO2-26.9%CaO-24.40%Na2O-xMgO-2.6%P2O5 (where 0≤x≤3 mol %) are bioactive and biocompatible both in vitro and in vivo 14,24 . It is well reported that magnesium slows down the crystallization of the apatite layer 16,17 , however, in this work we report the formation of an apatitelike phase after 1 h of soaking in SBF as it can be seen in Figure 3.…”

Section: Resultsmentioning

confidence: 99%

“…Magnesium is essential to bone metabolism, and it has been shown to have stimulating effects on new bone formation 13 . It plays a significant role in stimulating osteoblastic cells, and it reduces bone resorption 14 . In this regard, magnesium-contained bioactive glasses are widely studied 3,14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…It plays a significant role in stimulating osteoblastic cells, and it reduces bone resorption 14 . In this regard, magnesium-contained bioactive glasses are widely studied 3,14,15 . It was found that the incorporation of MgO in the bioactive glass accelerates the early stages of the precipitation of HAC layer 15 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

View full text Add to dashboard Cite

Glasses in the quaternary and quinary system SiO2-CaO-MgO-P2O5 (SCMP), SiO2-Na2O-CaO-P2O5 (SNCP) and SiO2-Na2O-CaO-MgO-P2O5 (SNCMP), have been prepared by using the sol-gel technique. Investigations of structural and bioactive properties of these glasses have been undertaken by using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS). The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for up to 30 days at 37°C. X-ray diffraction patterns indicated the formation of hydroxycarbonated apatite layer (HCA) after only one hour for SNCMP glass and after four days for SCMP and SNCP glasses. Furthermore, observed bands of FTIR spectra confirmed the growth of HCA layer during in vitro test.Moreover, the dissolution rate has been investigated using energy-dispersive X-ray spectroscopy. The observed EDS patterns confirmed the growth of HCA layer on all samples surfaces during in vitro analysis. On the one hand, we report the existence of Na2Ca2Si3O9 (that couple good mechanical strength with satisfactory biodegradability) as a single crystalline phase in the SNCP glass when calcined at 600°C. On the other hand, we have noticed that the coexistence of magnesium and sodium both enhanced the dissolution rate and hindered the crystallization in the SNCMP glass at 600°C.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The documentation of healthcare delivery is one of the new initiatives to converse and negotiate the implementation of best treatments for the patients. 19…”

Section: Resultsmentioning

confidence: 99%

Challenges in management of prescriptions for patient-centric care

Nagappa

Chikkamath

Naik

et al. 2018

MOJBB

View full text Add to dashboard Cite

The paradigm changes from the product-centric market to patient1 centric care are a revolutionary change in health care delivery. The Federation of International Pharmacy (FIP), WHO, and all most all drug regulatory authorities of the developed countries are emphasizing on the importance of patient centric care and outcome research to measure quality of life of the patients. The governments are encouraging the health care providers for focusing on the patient care by providing the direct incentivizes on the other hand, health insurance companies are also putting pressure on health care providers to minimize the cost on medication by adapting to generic prescribing. In developing 2 countries, although the government has realized the importance of patient centric care, they are also emphasizing to set the house in order by bringing various laws and regulations for example Pharmacy Practice Regulations 2015. In this manner they are bringing out fundamental changes in implementing the existing laws and enacting the new laws in regulations to improve the quality of life of patients. In this article we discuss the trends and their impact on clinical, humanistic and economic outcomes.

show abstract

“…[ 164 ] In particular, BG, especially mesoporous BG (MBG), can load other bioactive metal ions by replacing some of the calcium ions in the original BG and achieve a certain controlled release effect. [ 165–170 ] Bari et al prepared Cu−MBG by inserting copper ions into the frame of the MBG framework by sol−gel method. The results showed that Cu 2+ release was almost linear in the case of Cu−MBG 2% (molar ratio Cu/Ca/Si = 2/13/85), and the percentage of release was about 90% after 7 days of immersion.…”

Section: Problems To Be Considered In Doping Metals Into Biodegradabl...mentioning

confidence: 99%

Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Liu

et al. 2022

Adv Eng Mater

View full text Add to dashboard Cite

The election of bone tissue engineering scaffolds material is mainly based on the bionics of natural bones. Although the content of trace elements in bone is low, the lack of them affects the growth and metabolism of bones, thus increasing the risk of orthopedic diseases caused by the deterioration of bone quality. Therefore, inspired by trace elements in natural bone, biodegradable polymer composite scaffolds doped with bioactive metals such as Mg, Zn, Sr, Fe, Cu, Mn, Co, Li, Ag, Nb, and V have attracted more attention. Herein, the role of bioactive metals doping in biodegradable polymer matrix is mainly reviewed, including improving hydrophilicity, preventing aseptic inflammation caused by acidic degradation products, imparting antibacterial activity, improving mechanical properties, and promoting vascularization of polymer scaffolds. Then, the reasons and solutions for interfacial bonding and cytotoxicity caused by doping bioactive metals are focused on.

show abstract

Preparation and in vitro investigation on bioactivity of magnesia-contained bioactive glasses

Cited by 10 publications

References 41 publications

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

Challenges in management of prescriptions for patient-centric care

Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Contact Info

Product

Resources

About