“…This finding was also confirmed by Hu et al [47] and Sato et al [48], which reported good cell behavior in contact with coatings of similar compositions.…”
Section: Strengths Of Titanium Dioxide In Bone Tissue Engineeringsupporting
confidence: 85%
“…In this respect, in spite of the numerous studies and applications of HA/TiO 2 composites as bioactive coatings for load-bearing titanium prostheses [46][47][48][49], only a few studies were reported so far about the development of bulk TiO 2 -containing composites addressed to the development of bone scaffolds [50,51].…”
Section: Strengths Of Titanium Dioxide In Bone Tissue Engineeringmentioning
Titanium and its alloys have been extensively used as implantation materials due to their favorable properties such as lower modulus, good tensile strength, excellent biocompatibility, and enhanced corrosion resistance. However, their intrinsic bioinertness generally prevents a direct bond with the bone on the surface especially at an early stage of implantation. In recent years, bioactive scaffolds for bone regeneration are progressively replacing bioinert prostheses in orthopedic, maxillofacial, and neurosurgery fields. Given the need of enhanced mechanical strength, several combinations of bioactive and reinforcing phases have been studied, but still no convincing solutions have been found so far. In this context, titanium oxides are light and high-resistance bioactive materials widely employed in dental and bone application due to their capacity of forming strong bonds with bone tissue via the formation of a tightly bound apatite layer on their surface. The addition of titania particles to hydroxyapatite has attracted considerable attention based on the assumption that resulting materials can enhance osteoblast adhesion and promote cell growth while also providing high strength and fracture toughness in the final composite material, thus being adequate for load-bearing applications.
“…This finding was also confirmed by Hu et al [47] and Sato et al [48], which reported good cell behavior in contact with coatings of similar compositions.…”
Section: Strengths Of Titanium Dioxide In Bone Tissue Engineeringsupporting
confidence: 85%
“…In this respect, in spite of the numerous studies and applications of HA/TiO 2 composites as bioactive coatings for load-bearing titanium prostheses [46][47][48][49], only a few studies were reported so far about the development of bulk TiO 2 -containing composites addressed to the development of bone scaffolds [50,51].…”
Section: Strengths Of Titanium Dioxide In Bone Tissue Engineeringmentioning
Titanium and its alloys have been extensively used as implantation materials due to their favorable properties such as lower modulus, good tensile strength, excellent biocompatibility, and enhanced corrosion resistance. However, their intrinsic bioinertness generally prevents a direct bond with the bone on the surface especially at an early stage of implantation. In recent years, bioactive scaffolds for bone regeneration are progressively replacing bioinert prostheses in orthopedic, maxillofacial, and neurosurgery fields. Given the need of enhanced mechanical strength, several combinations of bioactive and reinforcing phases have been studied, but still no convincing solutions have been found so far. In this context, titanium oxides are light and high-resistance bioactive materials widely employed in dental and bone application due to their capacity of forming strong bonds with bone tissue via the formation of a tightly bound apatite layer on their surface. The addition of titania particles to hydroxyapatite has attracted considerable attention based on the assumption that resulting materials can enhance osteoblast adhesion and promote cell growth while also providing high strength and fracture toughness in the final composite material, thus being adequate for load-bearing applications.
“…In this respect, in spite of the numerous studies and applications of HA/TiO 2 composites as bioactive coatings for load-bearing titanium prostheses (Hae-Won et al, 2004;Hu et al, 2010;Li et al, 2002;Milella et al, 2001;Sato et al, 2008;Stoch et al, 2001), a lesser number of studies were reported so far about the development of bulk TiO 2 -containing composites addressed to the development of bone scaffolds (Fidancevska et al, 2007;Lee et al, 2007;Nath et al, 2009;Que et al, 2008). Some papers (Lee et al, 2007;Que et al, 2008) reported the use of complex technologies such as spark plasma sintering or hot pressing to obtain TCP/TiO 2 composites starting from hydroxyapatite and titania powders, whereas Nath et al (2009) used metallic titanium as starting material to obtain TCP/TiO 2 composites by conventional sintering in air at different temperatures.…”
“…7(b)). In general, the formation of ␣-and -TCP or CaTiO 3 compounds present in the coating layer could improve the apatite-forming ability to a greater extent than with the titanium oxide alone [22][23][24]. Nevertheless, the 3-day period was insufficient to form spherical biomimetic apatite covering the entire sample.…”
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