Preparation and In vitro Evaluation of FDM 3D-Printed Ellipsoid-Shaped Gastric Floating Tablets with Low Infill Percentages

Chen, Di; Xu, Xiangyu; Li, Rui; Zang, G A; Zhang, Yue; Wang, Ming-Rui; Xiong, Meng-Fei; Xu, Jiaxi; Wang, Ting; Fu, Hui; Hu, Qin; Wu, Bin; Yan, Guangrong; Fan, Tian-Yuan

doi:10.1208/s12249-019-1521-x

Cited by 50 publications

(36 citation statements)

References 49 publications

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“…The DSC measurement of pure propranolol HCl showed an endothermic event at about 165 °C, which was consistent with literature data for the melting point of the drug [ 42 ]. Above a temperature of about 200 °C, the active ingredient began to decompose, which can be recognized by a sudden sharp drop in the heat flow [ 43 ].…”

Section: Discussionsupporting

confidence: 89%

3D Printing of Mini Tablets for Pediatric Use

et al. 2021

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In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

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Section: Discussionsupporting

confidence: 89%

3D Printing of Mini Tablets for Pediatric Use

et al. 2021

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“…The higher porosity of lower infill density has a higher surface area and allows easy entry of the dissolution media into the core, resulted in a faster release of API. Yang et al [35] and Chen et al [36], who used FDM 3D printing for the development of controlled release dosage forms, reported that a higher fill density caused a reduction in the total surface area and resulted in slower drug release from the dosage forms.…”

Section: In Vitro Dissolution Studymentioning

confidence: 99%

Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing

2020

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This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based filaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material for printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the core. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness: 0.8, 1.2, 1.6, and 2.0 mm; wall thickness: 0, 0.8, and 1.6 mm; and % infill density: 50, 75, and 100) were designed, printed, and evaluated. All core-shell tablets floated without any lag time and exhibited good floating behavior throughout the dissolution study. The lag time for the pulsatile release of the drug was 30 min to 6 h. The proportion of ethyl cellulose in the filament composition had a significant (p < 0.05) effect on the lag time. The formulation (2 mm shell thickness, 1.6 mm wall thickness, 100% infill density, 0.5% EC) with the desired lag time of 6 h was selected as an optimized formulation. Thus, FDM 3D printing is a potential technique for the development of complex customized drug delivery systems for personalized pharmacotherapy.

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“…For instance, Skowrya et al noticed that majority of the drug (>80%) was released after 12 h and over 18 h with doses equal to 4, 5, 7.5 and 10 mg. Moreover, the complete drug release was achieved within 16 h for smaller tablets and within 20–24 h for bigger ones, due to a smaller SA/V ratio [ 44 ]. The BP acceptance limit was met only by formulations with an immediate drug release profile.…”

Section: Resultsmentioning

confidence: 99%

“…The hardness test defined also as breaking force test was most performed in the SLS included articles, with a percentage equal to 83%. Considering FDM 3DP technique, this test was performed in only half of the cases (51%), whereas with inkjet 3DP in only a reduced number of publications [ 20 ] and some cases the hardness could not be evaluated, because the value was above the maximum limit measurable by the hardness tester (>800 N), whereas in the works conducted by Khaled et al the hardness had values within a range of 24.67 N to 24.78 N [ 40 , 44 ], instead of in the article carried out by Okwuosa et al and Pietrzak et al was 350 N and 490 N, respectively [ 46 , 47 ]. The main parameters which affected the hardness were the number of excipients added in the formulation and the laser scanning speed [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

3DP Printing of Oral Solid Formulations: A Systematic Review

et al. 2021

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Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their manufacture are FDM, inkjet 3DP, SLA and SLS. This systematic review is carried out to statistically analyze the current 3DP techniques employed in manufacturing oral solid formulations and assess the recent trends of this new technology. The work has been organised into four steps, (1) screening of the articles, definition of the inclusion and exclusion criteria and classification of the articles in the two main groups (included/excluded); (2) quantification and characterisation of the included articles; (3) evaluation of the validity of data and data extraction process; (4) data analysis, discussion, and conclusion to define which technique offers the best properties to be applied in the manufacture of oral solid formulations. It has been observed that with SLS 3DP technique, all the characterisation tests required by the BP (drug content, drug dissolution profile, hardness, friability, disintegration time and uniformity of weight) have been performed in the majority of articles, except for the friability test. However, it is not possible to define which of the four 3DP techniques is the most suitable for the manufacture of oral solid formulations, because the selection is affected by different parameters, such as the type of formulation, the physical-mechanical properties to achieve. Moreover, each technique has its specific advantages and disadvantages, such as for FDM the biggest challenge is the degradation of the drug, due to high printing temperature process or for SLA is the toxicity of the carcinogenic risk of the photopolymerising material.

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Preparation and In vitro Evaluation of FDM 3D-Printed Ellipsoid-Shaped Gastric Floating Tablets with Low Infill Percentages

Cited by 50 publications

References 49 publications

3D Printing of Mini Tablets for Pediatric Use

3D Printing of Mini Tablets for Pediatric Use

Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing

3DP Printing of Oral Solid Formulations: A Systematic Review

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