Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method

El-Rashidy, Aiah A.; Waly, Gihan H.; Gad, Ahmed; Hashem, Azza; Balasubramanian, Preethi; Kaya, Seray; Boccaccını, Aldo R.; Sami, Inas

doi:10.1016/j.jnoncrysol.2017.12.044

Cited by 60 publications

(34 citation statements)

References 49 publications

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“…Recently, Ag-doped BG nanoparticles have been produced by a new modified Stöber method to incorporate higher amounts of Ag + ions in shorter times. Compared to traditional sol–gel processes, antibacterial tests revealed lower effectiveness in terms of inhibition zone, while in vitro bioactivity tests in SBF at 3, 7, and 14 days assessed the lower bioactive potential resulting from the new method [ 68 ]. A good antibacterial effect of Ag-doped BG foam scaffolds against Staphylococcus aureus was also recently reported [ 69 ].…”

Section: Interaction Of Bgs With the Physiological Environment: Gementioning

confidence: 99%

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Fiume

Barberi

Verné

et al. 2018

JFB

206

100

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Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide. Moreover, recent studies show the effectiveness of BGs in the regeneration of soft tissues, too. Often, surgical criteria do not match the engineering ones and, thus, a compromise is required for getting closer to an ideal outcome in terms of good regeneration, mechanical support, and biocompatibility in contact with living tissues. The aim of the present review is providing a general overview of BGs, with particular reference to their use in clinics over the last decades and the latest synthesis/processing methods. Recent advances in the use of BGs in tissue engineering are outlined, where the use of porous scaffolds is gaining growing importance thanks to the new possibilities given by technological progress extended to both manufacturing processes and functionalization techniques.

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Section: Interaction Of Bgs With the Physiological Environment: Gementioning

confidence: 99%

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Fiume

Barberi

Verné

et al. 2018

JFB

206

100

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“…16 Aiah et al doped MBGNs with silver ions and found that Ag-MBGNs were bioactive and antibacterial against Gram-positive and Gramnegative bacteria. 17 It has been reported in the literature that MBGNs constitute an attractive vector for therapeutically active ions since they exhibit an intrinsic pro-osteogenic potential that can be improved by the incorporation of therapeutically active ions. 16 The properties and the synthesis of sol-gel derived MBGNs have been reviewed by Kai et al 18 Chitosan is a well-known biocompatible natural biopolymer, which can improve the cellular interaction between the implant and the bone.…”

Section: Introductionmentioning

confidence: 99%

Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

et al. 2020

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“…The presence of BG particles in the nanofibers did not change the overall appearance of the spectra but added two bands related to Si–O–Si groups. A band located in the range of 1000–1200 cm −1 associated with Si–O–Si asymmetric stretching vibration and a band that corresponds to the Si–O–Si symmetric stretching vibration at around 800 cm −1 …”

Section: Resultsmentioning

confidence: 99%

“…A band located in the range of 1000-1200 cm −1 associated with Si-O-Si asymmetric stretching vibration and a band that corresponds to the Si-O-Si symmetric stretching vibration at around 800 cm −1 . 6,13 The water contact angle results are summarized in Table I. The angles were measured after 10 s relaxation and stability of the water droplet.…”

Section: Scaffolds Characterizationmentioning

confidence: 99%

“…Bioactive glasses (BGs) are amongst the most promising category of bone regenerating biomaterials due to their biodegradation and hydroxyapatite (HA) formation ability in body fluid. 5,6 In addition, the ionic products of BGs (depending on initial composition) following degradation, have shown to stimulate osteogenic differentiation of stem cells in vitro. 7,8 However, the brittle nature of BGs limits their load-bearing medical applications.…”

Section: Introductionmentioning

confidence: 99%

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Creation of a unique architectural structure of bioactive glass sub‐micron particles incorporated in a polycaprolactone/gelatin fibrous mat; characterization, bioactivity, and cellular evaluations

Fanaee

Labbaf

Houreh

et al. 2019

J Biomedical Materials Res

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In this study, submicron, monodispersed, spherical bioactive glass (BG) particles with a mean diameter of 720 ± 80 nm were produced through sol–gel process. The prepared BG particles were successfully incorporated into 70/30 (W/W) ratio of polycaprolactone/gelatin (PCL/GT) nanofibrous mats (250 ± 60 nm) through electrospinning to obtain a unique architectural structure for the first time. To enhance biodegradation and stability of the scaffolds, crosslinking using gluteraldehyde was applied. The structure, wettability, hydroxyapatite (HA) formation, cell adhesion, cell viability and osteogenic potential of the fibrous mats were evaluated. A continuous, uniform and hydrophilic structure of PCL/GT/BG was obtained. The fibers were found to be bioactive as they formed HA on their surface after immersion in simulated body fluid. The unique structure significantly reduced HA formation time to 5 days. For in vitro investigations, human dental pulp stem cells (hDPSCs) were cultured on PCL/GT and PCL/GT/BG fibrous mats. Results demonstrated good cell attachment after 4 and 24 h with no significant levels of cytotoxicity during 10 days of culture. Alizarin red staining was applied to quantitatively analyze the potential of PCL/GT/BG in osteogenic differentiation of hDPSCs. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method

Cited by 60 publications

References 49 publications

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

Creation of a unique architectural structure of bioactive glass sub‐micron particles incorporated in a polycaprolactone/gelatin fibrous mat; characterization, bioactivity, and cellular evaluations

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