Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in Treatment of Conjunctivitis

Chen, Qian; Yin, Chenghong; Ma, Jiang; Tu, Jiasheng; Shen, Yan

doi:10.3390/pharmaceutics11040183

Cited by 7 publications

(4 citation statements)

References 45 publications

(50 reference statements)

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“…The XRD patterns of PVP, HA, EFH, their physical mixture (PM), and the blank and drug-loaded nanofibers are presented in Figure 2 . The diffractograms of PVP and HA showed a broad halo amorphous pattern, which is consistent with the XRD results of Tawfik et al [ 39 ], Bai et al [ 40 ], Chuc-Gamboa et al [ 41 ], and Chen et al [ 42 ]. The diffraction of EFH displayed several characteristic Bragg reflections, indicating the crystallinity of the drug.…”

Section: Resultssupporting

confidence: 89%

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Almuwallad,

Alzahrani,

Aburayan

et al. 2023

Pharmaceutics

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Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through shaving or waxing. Laser or electrolysis are alternative methods, but in some cases, the use of medications, such as the topical cream Vaniqa®, can help in reducing the growth of unwanted hair. Electrospun fibers have been used in several drug delivery applications, including skin care products, owing to their biocompatibility, biodegradability, high surface area-to-volume ratio, and dry nature that can release the encapsulated drugs with maximum skin penetration. Therefore, polyvinyl pyrrolidone (PVP) fibers were fabricated in combination with hyaluronic acid to deliver the active compound of Vaniqa®, i.e., Eflornithine hydrochloride (EFH), as a face mask to inhibit excess facial hair growth. The prepared drug-loaded fibers showed a diameter of 490 ± 140 nm, with an encapsulation efficiency of 88 ± 7% and a drug loading capacity of 92 ± 7 μg/mg. The in vitro drug release of EFH-loaded fibers exhibited an initial burst release of 80% in the first 5 min, followed by a complete release after 360 min, owing to the rapid disintegration of the fibrous mat (2 s). The in vitro cytotoxicity indicated a high safety profile of EFH at all tested concentrations (500–15.625 μg/mL) after 24-h exposure to human dermal fibroblast (HFF-1) cells. Therefore, this drug-loaded nanofibrous system can be considered a potentially medicated face mask for the management of hirsutism, along with the moisturizing effect that it possesses. Topical applications of the developed system showed reduced hair growth in mice to a certain extent.

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Section: Resultssupporting

confidence: 89%

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Almuwallad,

Alzahrani,

Aburayan

et al. 2023

Pharmaceutics

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“…Thermogram of azithromycin records a sharp endothermic peak at 137˚C (onset at 111˚C) indicating the melting of azithromycin crystals. After 230˚C, decomposition of the drug was observed (32). Thermogram of azithromycin patch showed a broad endotherm over a temperature range of 67-77˚C, representing a composite glass transition of the blended mass.…”

Section: Physicochemical Evaluationmentioning

confidence: 99%

Antibiofilm Effects of Macrolide Loaded Microneedle Patches: Prospects in Healing Infected Wounds

et al. 2021

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Aim:The aim of this study was to fabricate polymeric microneedles, loaded with macrolides (erythromycin, azithromycin), using hyaluronic acid and polyvinyl pyrollidone.Methods: These microneedles were fabricated using a vacuum micromolding technique. The integrity of the microneedle patches was studied by recording their morphologic features, folding endurance, swelling and micro-piercing. Physicochemical characteristics were studied by differential scanning calorimetry, thermogravimetric analysis and fourier transform infrared spectroscopy. In-vitro drug release, antibiofilm and effect of microneedle patch on wound healing were also studied to confirm the efficacy of the formulations.Results: Formulated patches displayed acceptable folding endurance (>100) and uniform distribution of microneedles (10x10) that can penetrate parafilm. Differential scanning calorimetry results depict a decrease in the crystallinity of macrolides following their incorporation in to a polymer matrix. Percentage release of azithromycin and erythromycin from the polymeric patch formulations (over 30 minutes) was 90% and 63% respectively.Broadly, the zone of bacterial growth inhibition follows the same order for Staphylococcus aureus, Escherichia coli and Salmonella enterica. After 5 days of treatment with azithromycin patches, the wound healing was complete and skin structure (e.g. hair follicles and dermis) was regenerated. Conclusion:It was concluded that azithromycin loaded microneedle patches can be used to treat biofilms in the infected wounds.

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“…Salzillo et al [ 124 ] also reported an increase in viscosity and mucoadhesion of the HA-based samples on simulated corneal–conjunctival epithelial mucin with an increase in HA concentration, with a more marked increase in such parameters with an increase in HA MW from 250 to 1120 kDa. Chen et al [ 125 ] demonstrated the enhanced mucoadhesion of sodium hyaluronate (SH)–azithromycin eye drops in comparison to an azithromycin formulation containing hydroxypropyl methylcellulose (HPMC). The mean residence time of the SH formulation on rabbit eyes was approximately 1.56 times greater than that of the HPMC formulation, which they attributed to the combined viscoelasticity and bioadhesive nature of SH.…”

Section: Hyaluronic Acid Biomaterials For Ocular Drug Deliverymentioning

confidence: 99%

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

et al. 2022

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Extensive research is currently being conducted into novel ocular drug delivery systems (ODDS) that are capable of surpassing the limitations associated with conventional intraocular anterior and posterior segment treatments. Nanoformulations, including those synthesised from the natural, hydrophilic glycosaminoglycan, hyaluronic acid (HA), have gained significant traction due to their enhanced intraocular permeation, longer retention times, high physiological stability, inherent biocompatibility, and biodegradability. However, conventional nanoformulation preparation methods often require large volumes of organic solvent, chemical cross-linkers, and surfactants, which can pose significant toxicity risks. We present a comprehensive, critical review of the use of HA in the field of ophthalmology and ocular drug delivery, with a discussion of the physicochemical and biological properties of HA that render it a suitable excipient for drug delivery to both the anterior and posterior segments of the eye. The pivotal focus of this review is a discussion of the formation of HA-based nanoparticles via polyelectrolyte complexation, a mild method of preparation driven primarily by electrostatic interaction between opposing polyelectrolytes. To the best of our knowledge, despite the growing number of publications centred around the development of HA-based polyelectrolyte complexes (HA-PECs) for ocular drug delivery, no review articles have been published in this area. This review aims to bridge the identified gap in the literature by (1) reviewing recent advances in the area of HA-PECs for anterior and posterior ODD, (2) describing the mechanism and thermodynamics of polyelectrolyte complexation, and (3) critically evaluating the intrinsic and extrinsic formulation parameters that must be considered when designing HA-PECs for ocular application.

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Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in Treatment of Conjunctivitis

Cited by 7 publications

References 45 publications

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Antibiofilm Effects of Macrolide Loaded Microneedle Patches: Prospects in Healing Infected Wounds

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

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