Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering

Subramanian, Anuradha; Vu, David; Larsen, Gustavo; Lin, Hsin-Yi

doi:10.1163/1568562054255682

Cited by 190 publications

(120 citation statements)

References 42 publications

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…The application of nanofibres in research aiming to obtain new materials for medicine has been reflected in numerous publications [27,29,30]. The relevant literature includes many papers devoted to the use of nanofibres in the treatment of osseous tissue [31,32], articular cartilages [33,34], muscles [35], ligaments [36], skin [12,37] and use in cardiosurgery [9].…”

Section: Methods Of Obtaining and Characterising The Spinning Solutionmentioning

confidence: 99%

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Krucińska

Chrzanowska

Boguń

et al. 2014

Autex Research Journal

View full text Add to dashboard Cite

The study presents the manufacturing of nanofibrous structures as osteoconductive, osteoinductive materials for osseous tissue regeneration. The fibrous structures were obtained by electrospinning of poly(l-lactide-coglicolide) (PLGA) with addition of hydroxyapatite (HAp) and of a blend of PLGA with polyhydroxybutyrate with HAp added. The polymers used in the experiment were synthesised by an innovative method with a zirconium catalyst. First, the optimal electrospinning process parameters were selected. For the characterisation of the obtained osseous tissue reconstruction materials, the physical, macroscopic, functional, mechanical and thermal properties as well as crystallinity index were studied. The study of the radiation sterilisation influence on average molar mass, thermal and mechanical properties was made in order to analyse the degradation effect.

show abstract

Section: Methods Of Obtaining and Characterising The Spinning Solutionmentioning

confidence: 99%

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Krucińska

Chrzanowska

Boguń

et al. 2014

Autex Research Journal

View full text Add to dashboard Cite

show abstract

“…In this setup instead of electrospinning onto a rotating mandrel a rotating disk is used as a collector [27]. This results in fibres which are aligned relatively to the disk.…”

Section: Collector Modificationsmentioning

confidence: 99%

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

Mortimer¹,

Widdowson²,

Wright³

2018

Novel Aspects of Nanofibers

View full text Add to dashboard Cite

Nanofibers are an important material for regenerative medicine as they have a commensurate morphology to that of the macromolecular matrix that supports and houses the growth of cells and tissues within the body. Electrospinning is widely used to fabricate non-woven structures on the nanoscale and the versatility of the technique has widened the application of nanofibers. This is due to ease of extending nanofiber functionality through the incorporation of active materials both during and after electrospinning. Recent developments in electrospinning devices, such as needle-free systems, have reinvigorated research as these advances now allow fabrication of nanofibers at commercial scales. The process of electrospinning has a number of operating parameters that are adjusted in optimisation to achieve ideal fibres and a multitude of instrument configurations can be adopted to achieve the required manufacture. The innate properties of nanofibers, such as high surface area to volume ratio, have many proven benefits for regenerative medicine and the chapter examines these before discussing how functionality can be further improved. Numerous materials can be incorporated in the manufacture of electrospun mats, however when choosing materials for regenerative medicine, biocompatibility and biodegradability are the dominant functionalities that are required.

show abstract

“…This nanofibrous matrix is of particular interest in tissue engineering for controlled drug release and tissue remodeling. Similarly, Subramaniyan et al, 2005 prepared chitosan/PEO nanofibers for cartilage tissue engineering. In this study, chitosan/PEO nanofibers was evaluated the biocompatibility with chondrocytes.…”

Section: Applications Of Chitin and Chitosan Nano-fibers In Tissue-enmentioning

confidence: 99%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

View full text Add to dashboard Cite

Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

show abstract

Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering

Abstract: , "Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering" (2005). Papers in Biotechnology. 29.

Cited by 190 publications

References 42 publications

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Contact Info

Product

Resources

About