Preparation and Evaluation of Taste-Masked Donepezil Hydrochloride Orally Disintegrating Tablets

Yan, Yongyong; Woo, Jong Soo; Kang, Joon Heok; Yong, Chul Soon; Choi, Han‐Gon

doi:10.1248/bpb.33.1364

Cited by 63 publications

(42 citation statements)

References 21 publications

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“…In vitro fluid systems that mimic the lumen of the buccal cavity In vivo, the composition of salivary fluid changes in response to a number of stimuli (Yan et al, 2010). Despite this, most simulated salivary fluid experiments use set concentrations of salts, amylase and pH.…”

Section: In Vitro Non-cellular Fluid Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

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Section: In Vitro Non-cellular Fluid Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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“…Recently, several orally disintegrating tablets (ODTs) for OAB management have become available in addition to conventional tablets. [8][9][10][11] The ODT formulation disintegrates immediately in the mouth so that patients can ingest it without water. This characteristic of ODTs is beneficial for patients who have difficulty swallowing conventional tablets or those who do not have immediate access to water.…”

Section: )mentioning

confidence: 99%

Combination Effect of Physical and Gustatory Taste Masking for Propiverine Hydrochloride Orally Disintegrating Tablets on Palatability

2015

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Orally disintegrating tablets (ODTs) containing propiverine hydrochloride (which is extremely bitter and leaves a feeling of numbness in the mouth) were prepared with a combined use of physical and organoleptic taste masking. Propiverine-loaded masking particles (PLMPs) were prepared with different amounts of gastric-soluble coatings as physical masking. ODTs without organoleptic masking were prepared by mixing each group of PLMPs with Ludiflash ® , crospovidone, and magnesium stearate. ODTs with organoleptic masking were also prepared by addition of L-menthol, aspartame, thaumatin, and cinnamon. Fifteen-minute dissolution of propiverine in solutions with pH 1.2 was ≥85% for all ODTs, whereas that in pH 6.8 solutions was ≤85% and increased with physical masking. A single blind randomized crossover trial was conducted. Ten healthy volunteers were asked to quantify the bitterness, numbness, and overall palatability using a 100-mm visual analog scale (VAS) at the period of disintegration as well as 1 and 5 min later. VAS scores of bitterness, numbness, and overall palatability improved along with increasing amounts of physical masking, and the effects persisted for 5 min. VAS scores for numbness increased over time regardless of the amount of physical masking. Bitterness, numbness, and overall palatability were significantly improved by organoleptic masking if the amount of physical masking was small. Combined use of physical and organoleptic masking is useful for improving palatability of ODTs containing propiverine.

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“…Oral dose formulations are the most common because of their non-invasive administration route. Various formulations have been developed: orally disintegrating tablets (ODTs), [5][6][7][8] effervescent tablets, 9) oral fast-dissolving film formulations, 10,11) oral jelly formulations, 12) and gummi formulations. [13][14][15] Among the formulations mentioned above that have been developed to improve adherence, "gummi formulations" have attracted attention because they do not require water for consumption, and can be chewed easily.…”

mentioning

confidence: 99%

Development of Gummi Drugs of Aripiprazole as Hospital Formulations

Uchida

Hiraoka

Namiki

2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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About half of patients with schizophrenia have poor adherence to taking medication, so many have recurrence, therefore, providing formulations that enable patients to continue their medication without interruption is important. We aimed to develop a gummi drug that contains aripiprazole (which can reduce schizophrenia and manic symptoms in bipolar disorder). We were able to develop gummi drugs (OD-G, PW-G and OS-G) using three commercially available aripiprazole products (Abilify ® orally disintegrating tablets, powder formulation, and oral solutions, respectively) as hospital formulations. Furthermore, we developed improved OD-G (iOD-G), which contained high aripiprazole content. Pharmaceutical characteristics of iOD-G were demonstrated to be suitable for hospital formulations, and iOD-G could be stored for ≤1 month. No significant differences in the dissolution and pharmacokinetics of divided portions of iOD-G were observed when compared with commercially available aripiprazole products. This study confirmed that new dosage forms of aripiprazole in gummi drugs can be developed as hospital formulations, which will contribute to improve medication adherence of patients.

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Preparation and Evaluation of Taste-Masked Donepezil Hydrochloride Orally Disintegrating Tablets

Cited by 63 publications

References 21 publications

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Combination Effect of Physical and Gustatory Taste Masking for Propiverine Hydrochloride Orally Disintegrating Tablets on Palatability

Development of Gummi Drugs of Aripiprazole as Hospital Formulations

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