Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose

Wu, Pao‐Chu; Huang, Yaw‐Bin; Chang, Jui-I; Tsai, Ming-Jun; Tsai, Yi‐Hung

doi:10.1016/s0378-5173(03)00255-2

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…The release data were submitted to zero order, first order, Higuchi's and Peppas model (Reddy et al, 2003, Wu et al, 2003. The release model parameters for all the formulations are shown in Table IV.…”

Section: Kinetics Analysis Of Release Studymentioning

confidence: 99%

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Hussain

Mumtaz²,

Arshad

et al. 2016

Braz. J. Pharm. Sci.

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The present study describes the development of theophylline microcapsules by a non-solvent addition method and the effect of plasticizer addition on microencapsulation. The release was studied in distilled water and the data were analysed by various mathematical models for determining the mechanism of release. Prepared microcapsules were found to be spherical, free flowing and having more than 80% entrapped drug. The polymer -cellulose acetate phthalate and plasticizer -polyethylene glycol was considered to be affecting the properties of microcapsules including drug release (time for 50% drug release, T 50 ). The formulation with the highest proportion of polymer and without plasticizer (F3) showed the slowest release with T 50 = 4.3 h, while the formulation with lower proportion of polymer and 20% (w/w) plasticizer (F13 &14) showed the fastest release of drug with T 50 values of 1.2 h and 1.3 h, respectively. The drug release from most of the formulations was found to be following Higuchi model. It is concluded from the results of the present study that cellulose acetate phthalate significantly affects the sustained release of the drug in water, whereas the addition of polyethylene glycol slightly enhances the drug release.Uniterms: Theophylline/microcapsules. Microencapsulation. Cellulose acetate phthalate. Polyethylene glycol. Microcapsules/mechanism of release. Drugs/release. O presente estudo descreve o desenvolvimento de microcápsulas de teofilina pelo método sem adição de solvente e o efeito da adição de plastificante na microencapsulação. A liberação foi estudada em água destilada e os dados foram analisados por vários modelos matemáticos para determinação do mecanismo de liberação. As microcápsulas preparadas mostraram-se esféricas, livres de corrente e com mais de 80% de fármaco encapsulado. O polímero -ftalato de acetato de celulose e o plastificante -polietileno glicol -afetaram as propriedades das microcápsulas, incluindo a liberação do fármaco (tempo para liberação de 50% do fármaco, T 50 ). A formulação com a maior proporção de polímero e sem plastificante (F3) se mostrou como a de liberação mais lenta, com T 50 = 4,3 h, enquanto as formulações com menor proporção de polímero e 20% de plastificante (m/m) (F13 &14) apresentaram a liberação mais rápida do fármaco, com T 50 de 1,2 h e 1,3 h, respectivamente. A liberação do fármaco para a maioria das formulações seguiu o modelo de Higuchi. Concluiu-se, dos resultados do presente estudo, que o ftalato do acetato de celulose afeta significativamente a liberação controlada do fármaco em água, enquanto que a adição de polietileno glicol aumenta ligeiramente a liberação do fármaco.Unitermos: Teofilina/microcápsulas. Microencapsulação. Ftalato de acetato de celulose. Polietilenoglicol. Microcápsulas/mecanismo de liberação. Fármacos/liberação.

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Section: Kinetics Analysis Of Release Studymentioning

confidence: 99%

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Hussain

Mumtaz²,

Arshad

et al. 2016

Braz. J. Pharm. Sci.

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“…reservoir, monolithic and matrix types. [3][4][5] Carbomers are synthetic, high molecular weight cross linked polymer of acrylic acid. The hydrophilic nature and highly cross linked structure render them more suitable potential candidate for use in controlled drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Development of Mucoadhesive Sustained Release Matrix Tablets of Methimazole for oral Delivery

Ige¹,

Mahajan²,

Sonawane³

2015

IJPER

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The aim of the present investigation was to develop sustained release matrix tablets containing methimazole. The different batches were manufactured by direct compression method using hydrophilic swellable carbopol and ethocel and eudragit RL100 in combination using Minipress and characterized by FTIR, DSC, in vitro mucoadhesion, in vitro swelling, erosion and in vitro drug release and stability studies. It was found that, the formulation batch MT 6 has a mucoadhesion force about 14.813 ± 0.085 N. It has exhibited the adhesion retention time about 11.16 ± 0.10 h in the entire region of GIT with maximum swelling up to 59.52 ± 4.93 %. It is revealed that drug release by both mechanism diffusion and erosion. Carbopol 934P along with Eudragit RL100 and ethyl cellulose was found to be controlling the release rate of methimazole in matrix tablets for 20 h. It can be concluded that, there is promising potential for this system that can control the release up to 20 h and extend the drug release.

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“…Over the past few decades, microspheres are one of the microparticulate systems which have shown tremendous potential and are used for sustained or controlled drug delivery and to improve the therapeutic efficacy (Davis and Illum, 1988;Ritschel, 1989). Ethyl cellulose (EC) is a water insoluble, biocompatible and nontoxic cellulose polymer and is studied extensively as encapsulating agent for sustained release of drugs (Chowdary et al, 2004;Wu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Development and in-vitro characterization of lornoxicam loaded ethyl cellulose microspheres prepared by emulsion solvent evaporation method

Tyagi¹,

Kori²

2014

Afr. J. Pharm. Pharmacol.

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Advancement in drug delivery could come from innovating improvement to the existing drug delivery system. Lornoxicam (Lxm) loaded ethyl cellulose microspheres were prepared by emulsion solvent evaporation technique and also to investigate the effect of variations in drug concentration, polymer concentration, internal phase volume, continuous phase volume and emulsifier concentration on the particle size, shape, % yield, percent entrapment efficiency and in vitro drug release behavior. The scanning electron microscopy (SEM) revealed that microspheres had good spherical geometry with smooth surface. The result showed that the maximum yield of the microspheres was found to be 64.23 ± 0.25%, with particle size in the range of 64.24 ± 1.82 to 81.83 ± 3.43 μm and encapsulation efficiency was found to be in a range of 60.34 ± 1.63 to 71.61 ± 1.20%. The average particle size and entrapment efficiency of microspheres were enhanced with increasing polymer concentration but reduced with increasing internal phase volume, external phase volume and emulsifier concentration. In vitro release profile of microspheres was in the range of 75.65 ± 2.3 to 87.78 ± 2.3% at the end of 12 h. It was concluded that Lxm loaded ethyl cellulose microspheres formulation showed sustained effect over a period of 12 h.

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Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose

Cited by 21 publications

References 15 publications

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules

Development of Mucoadhesive Sustained Release Matrix Tablets of Methimazole for oral Delivery

Development and in-vitro characterization of lornoxicam loaded ethyl cellulose microspheres prepared by emulsion solvent evaporation method

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