Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride

Huh, Yeamin; Cho, Hyun‐Jong; Yoon, In‐Soo; Choi, Min‐Koo; Kim, Jung Sun; Oh, Euichaul; Chung, Suk‐Jae; Shim, Chang‐Koo; Kim, Dae‐Duk

doi:10.1016/j.ejps.2010.02.002

Cited by 67 publications

(43 citation statements)

References 34 publications

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“…The spray-drying process was applied to evaporate the moisture of the new mixture (shown in Scheme 1A). 33 A laboratory spray dryer (SY-6000; Shiyuan Biological Equipment Engineering Co. Ltd., Shanghai, People's Republic of China) with a standard 0.7 mm nozzle was used under the working condition: inlet temperature 160°C, pumping flow rate 500 mL/hour, spray air pressure 0.35 kg/cm 2 and drying air flow discharge 600 m 3 /hour. Thus, SeNPs-M were generated with the expected structure shown in Scheme 1B.…”

Section: Methodsmentioning

confidence: 99%

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Bai¹,

Hong²,

He³

et al. 2017

IJN

150

133

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Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD 50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings.

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Section: Methodsmentioning

confidence: 99%

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Bai¹,

Hong²,

He³

et al. 2017

IJN

150

133

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“…Moreover, a bioadhesive delivery system for the intranasal administration of a flu vaccine which comprised of esterified hyaluronic acid (HYAFF) microspheres in combination with a mucosal adjuvant (LTK63) was also reported to be effective (Singh et al, 2001). Also, a formulation of microparticles prepared by the spray dry method using HA-based microspheres containing PEG 6000 and/or sodium taurocholate for the nasal delivery of fexofenadine hydrochloride was able to enhance the AUC and Cmax values (Huh et al, 2010).…”

Section: Nasal Deliverymentioning

confidence: 99%

Hyaluronic Acid in Drug Delivery Systems

Jin¹,

Termsarasab²,

Kim³

2010

Journal of Pharmaceutical Investigation

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− Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications including arthritis treatment, wound healing, ocular surgery, and tissue augmentation. Because of its mucoadhesive property and safety, HA has received much attention as a tool for drug delivery system development. It has been used as a drug delivery carrier in both nonparenteral and parenteral routes. The nonparenteral application includes the ocular and nasal delivery systems. On the other hand, its use in parenteral systems has been considered important as in the case of sustained release formulation of protein drugs through subcutaneous injection. Particles and hydrogels by various methods using HA and HA derivatives as well as by conjugation with other polymer have been the focus of many studies. Furthermore, the affinity of HA to the CD44 receptor which is overexpressed in various tumor cells makes HA an important means of cancer targeted drug delivery. Current trends and development of HA as a tool for drug delivery will be outlined in this review.

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“…The results of drug permeation studies depend on the confluency of nasal epithelial cell monolayers. Polymer membranes that can be used include polyethyleneterephthalate Kissel, 1995, 1996), polycarbonate (Kienast et al, 1994) and polyester (Gray et al, 2001;Huh et al, 2010;Cho et al, 2010). Among commercially available polymer supports, the microscopic observation of cells cultured on the translucent polymer membrane is difficult to be acquired.…”

Section: Sampling Technique For Nasal Cells From Tissuementioning

confidence: 99%

“…Diverse drug types, including small molecule type chemicals (Cho et al, 2008;Huh et al, 2010), peptides (Chen et al, 2009;Yu and Kim, 2009), proteins (Jintapattanakit et al, 2010;Leitner et al, 2004), and nucleic acids (Bitko and Barik, 2008;Howard et al, 2006;Vetter et al, 2010), have been attempted for administration via the nasal route for local as well as systemic delivery. Nasal delivery has several advantages, which include rapid onset of action, non-invasiveness, avoidance of hepatic and intestinal first-pass metabolism, and self-medication (Costantino et al, 2007;Pires et al, 2009).…”

Section: Nasal Drug Deliverymentioning

confidence: 99%

In vitro Nasal Cell Culture Systems for Drug Transport Studies

Cho¹,

Termsarasab²,

Kim³

et al. 2010

Journal of Pharmaceutical Investigation

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− Growing interest in the nasal route as a drug delivery system calls for a reliable in vitro model which is crucial for efficiently evaluating drug transport through the nasal cells. Various in vitro cell culture systems has thus been developed to displace the ex vivo excised nasal tissue and in vivo animal models. Due to species difference, results from animal studies are not sufficient for estimating the drug absorption kinetics in humans. However, the difficulty in obtaining reliable human tissue source limits the use of primary culture of human nasal epithelial cells. This shortage of human nasal tissue has therefore prompted studies on the "passage" culture of nasal epithelial cells. A serially passaged primary human nasal epithelial cell monolayer system developed by the air-liquid interface (ALI) culture is known to promote the differentiation of cilia and mucin gene and maintain high TEER values. Recent studies on the in vitro nasal cell culture systems for drug transport studies are reviewed in this article.

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Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride

Cited by 67 publications

References 34 publications

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Hyaluronic Acid in Drug Delivery Systems

In vitro Nasal Cell Culture Systems for Drug Transport Studies

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