Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide

Guinedi, Ahmed S.; Mortada, Nahed D.; Mansour, Samar; Hathout, Rania M.

doi:10.1016/j.ijpharm.2005.09.023

Cited by 296 publications

(155 citation statements)

References 34 publications

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“…Because the high cholesterol content facilitated the formation of compact niosomal bilayers with reduced permeability and thus hindered the release of drug entrapped. [34,35] When the release data were fitted into various kinetic models, it was found that BCT release from the proniosomal formulations followed Higuchi kinetics. This model suggested the diffusion controlled release of the drug.…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lather¹,

Sharma²,

Pandita³

2016

Journal of Experimental Nanoscience

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Vesicular systems endow large opportunities for the transdermal delivery of therapeutics. The present study was designed to investigate the potential of a novel class of vesicular system 'proniosome' as a carrier for transdermal delivery of bromocriptine (BCT). Proniosome formulations were prepared by the coacervationphase separation method and the influence of factors like surfactant type and its amount, lipid concentration, cholesterol amount and drug content were studied. Span 60 was the most appropriate surfactant, and yielded vesicle size and percentage encapsulation efficiency of 1.3 mm and 98.9%, respectively. The developed system was characterised w.r.t. morphology, transition temperature, drug release, skin permeation and skin irritancy. Proniosomes exhibited a sustained release pattern of BCT in vitro. Skin permeation study revealed high penetration of proniosomes with sustained release of BCT through rat skin. The optimised proniosomal formulation showed enhanced transdermal flux of 16.15 mg/cm 2 /h as compared to 3.67 mg/cm 2 /h for drug dispersion. The developed formulations were observed as non-irritant to the rat skin and were found as quite stable at 4 and 25 C for 90 days w.r.t. vesicle size and drug content. The dried proniosomal formulation could act as a promising alternative to niosomes and preferably for transdermal delivery of BCT.

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Section: In Vitro Release Studiesmentioning

confidence: 99%

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lather¹,

Sharma²,

Pandita³

2016

Journal of Experimental Nanoscience

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“…However, the HLB is not the only factor that affects EE. The phase transition temperature (T c ) is directly proportional to the length of hydrocarbon alkyl chains of surfactants (Mohammed et al, 2004;Guinedi et al, 2005;El-Laithy et al, 2011). Surfactants with a higher T c and longer alkyl chain show higher EE because they are more likely to form gels in an ordered form with less ''leaky'' niosomes (ElLaithy et al, 2011).…”

Section: Entrapment Efficiency and Vesicle Sizementioning

confidence: 99%

Transdermal delivery of oxybutynin chloride proniosomal gels for the treatment of overactive bladder

et al. 2015

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Context: Overactive bladder (OAB) is a common problem and anticholinergic drugs are first-line therapy, but they have side effects. Objective: Development of oxybutynin chloride (OC) proniosomal gels and analyses of its efficacy for OAB treatment. Materials and methods: Phase separation coacervation was used to prepare proniosomal gels using various non-ionic surfactants, lipids, soy lecithin and isopropyl alcohol. Gels were characterized with regard to entrapment efficiency (EE), vesicle size, surface morphology (using environmental scanning electron microscopy [E-SEM]), stability, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, in vitro skin permeation, in vivo animal studies and histopathology. Results and discussion: EE was 87-92%, vesicle size was 0.38-5.0 mm, and morphology showed some loosened pores in proniosomes after hydration. ATR-FTIR spectroscopy showed no significant shifts in peaks corresponding to OC and excipients. Most formulations exhibited 450% permeation but the cholesterol-containing formulations P3 (Span 20:Span 60 [1:1]) and P4 [Tween 20:Tween 80 (1:1)] had the highest percent cumulative permeation. P3 and P4 also showed faster recovery of cholinergic effects on salivary glands than oral formulations. P3 and P4 had pronounced therapeutic effects in reduction of urinary frequency and demonstrated improvements in bladder morphology (highly regenerative surface of the transitional epithelium). Conclusion: These results suggest that OC could be incorporated into proniosomal gels for transdermal delivery in the treatment of OAB.

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“…The length of alkyl chain and phase transition temperature of surfactants was affecting the entrapment efficiency. Surfactants of longer alkyl chains and higher phase transition temperature showed higher entrapment efficiency (Guinedi et al, 2005). The results of %EE of lacidipine in niosomes are illustrated in Table 2 and was found to range from 44.06 ± 0.06% to 98.01 ± 0.683%.…”

Section: Determination Of Percentage Entrapment Efficiency (%Ee)mentioning

confidence: 96%

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2³factorial design andin vivoevaluation in rabbits

et al. 2016

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Context: Proniosomes offer a versatile vesicle drug delivery concept with potential for delivery of drugs via transdermal route. Objectives: To develop proniosomal gel using cremophor RH 40 as non-ionic surfactant containing the antihypertensive drug lacidipine for transdermal delivery so as to avoid its extensive first pass metabolism and to improve its permeation through the skin. Materials and methods: Proniosomes containing 1% lacidipine were prepared by the coacervation phase separation method, characterized, and optimized using a 2 3 full factorial design to define the optimum conditions to produce proniosomes with high entrapment efficiency, minimal vesicle size, and high-percentage release efficiency. The amount of cholesterol (X 1 ), the amount of soya lecithin (X 2 ), and the amount of cremophor RH 40 (X 3 ) were selected as three independent variables. Results and discussion: The system F4 was found to fulfill the maximum requisite of an optimum system because it had minimum vesicle size, maximum EE, maximum release efficiency, and maximum desirability. The optimized system (F4) was then converted to proniosomal gel using carbopol 940 (1% w/w). In vitro permeation through excised rabbit skin study revealed higher flux (6.48 ± 0.45) for lacidipine from the optimized proniosomal gel when compared with the corresponding emulgel (3.04 ± 0.13) mg/cm 2 /h. The optimized formulation was evaluated for its bioavailability compared with commercial product. Statistical analysis revealed significant increase in AUC (0 À a) 464.17 ± 113.15 ng h/ml compared with 209.02 ± 47.35 ng h/ml for commercial tablet. Skin irritancy and histopathological investigation of rat skin revealed its safety. Conclusions: Cremophor RH 40 proniosomal gel could be considered as very promising nanocarriers for transdermal delivery of lacidipine. KeywordsBioavailability study, 2 3 full factorial design, lacidipine, proniosomal gel transdermal delivery History

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Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide

Cited by 296 publications

References 34 publications

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Transdermal delivery of oxybutynin chloride proniosomal gels for the treatment of overactive bladder

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2³factorial design andin vivoevaluation in rabbits

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Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide

Cited by 296 publications

References 34 publications

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Transdermal delivery of oxybutynin chloride proniosomal gels for the treatment of overactive bladder

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23factorial design andin vivoevaluation in rabbits

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Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2³factorial design andin vivoevaluation in rabbits