Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads

Motycka, S.; Nairn, J. Graham

doi:10.1002/jps.2600680223

Cited by 39 publications

(11 citation statements)

References 24 publications

(3 reference statements)

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“…Drug release from the coated resinates has also been reported to follow the particle diffusion process. 26,29,30 However, diltiazem release from the PS-coated resinates was found to deviate from the particle diffusion mechanism. Hence, the data were fitted into the Korsmeyer-Peppas 31 equation Mt/M α = at n , where a is a constant incorporating structural and geometric characteristics of the dosage form; n is the release exponent, indicative of the drug release mechanism; and the function of t is Mt/M α (fractional release of drug).…”

Section: Kinetics Of Drug Releasementioning

confidence: 99%

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Halder

2006

AAPS PharmSciTech

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The purpose of this study was to examine the suitability of polystyrene-coated (PS-coated) microcapsules of drug-resin complex for achieving prolonged release of diltiazem-HCl, a highly water-soluble drug, in simulated gastric and intestinal fluid. The drug was bound to Indion 254, a cation-exchange resin, and the resulting resinate was microencapsulated with PS using an oil-in-water emulsion-solvent evaporation method. The effect of various formulation parameters on the characteristics of the microcapsules was studied. Mean diameter and encapsulation efficiency of the microcapsules rose with an increase in the concentration of emulsion stabilizer and the coat/core ratio, while the same characteristics tended to decrease with an increase in the volume of the organic disperse phase. The desorption of drug from the uncoated resinate was quite rapid and independent of the pH of the dissolution media. On the other hand, the drug release from the microcapsules was prolonged for different periods of time depending on the formulation parameters and was also found to be independent of the pH of the dissolution media. Both the encapsulation efficiency and the retardation of drug release were found to be dependent on the uniformity of coating, which in turn was influenced by the formulation parameters. Kinetic studies revealed that the desorption of drug from the resinate obeyed the typical particle diffusion process, whereas the drug release from the microencapsulated resinate followed the diffusioncontrolled model in accordance with the Higuchi equation. PS appeared to be a suitable polymer to provide prolonged release of diltiazem independent of the pH of the dissolution media.

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Section: Kinetics Of Drug Releasementioning

confidence: 99%

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Halder

2006

AAPS PharmSciTech

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“…Active ingredients, if ionized, can be bound with fixed ions of ion-exchange resins (4)(5)(6). The advantages of utilizing ion-exchange resins include the simple preparation method and no uncontrolled burst effect in the drug resinate even in case of high drug loading.…”

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confidence: 99%

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

et al. 2010

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Oral disintegrating tablets (ODTs) have advantages of solid dosage forms such as good stability, accurate dosing, small packaging size, and easy handling, as well as those of liquid formulations such as easy administration and minimal risk of suffocation. Therefore, they are beneficial for children, elderly and schizophrenic patients who have difficulty in swallowing conventional solid dosage forms (1). The success of ODT depends on patient acceptance, palatability and the challenging aspect in the formulation of orally disintegrating tablets is to mask the bitterness of active pharmaceutical ingredients, since most drugs have bitter taste. The distasteful sensation of a drug can be masked either by the addition of flavors, sweeteners and effervescent agents or by reducing direct contact with the patient's taste buds through coating or granulation (2, 3). Flavor is often overpowered by the taste of the medicine and the use of effervescent agents is not always convenient. Moreover, coating and granulation of the active ingredient may The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age groups. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of the particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calculated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.

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“…The ion-exchange resin could produce a sustained release effect when it complexes with the drug [10] . This multi-particulate system is mostly encapsulated using a polymer, which would provide a barrier for drug diffusion and further prolong the release effect [11][12][13] . The multi-particulate system is introduced into an ODT and compacted at a shear rate not to rupture the microcapsules.…”

Section: Research Papermentioning

confidence: 99%

Formulation, Development and Stability of Granisetron Sustained Release Oral Dispersible Tablets

Krishna¹,

Rangra²,

Samanta³

et al. 2018

pharmaceutical-sciences

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Krishna, et al.: Stability Study of Granisetron Sustained Release Oral Dispersible TabletsGranisetron, a selective 5-HT3 receptor antagonist has a good safety profile but a shorter half-life hence is only suited for a multiple-dosage regimen, which increased side effects. Ion-exchange resins were extensively investigated as potential drug release modulators and the ability to get encapsulated along with drugs appeared to be a distinct advantage. Optimized conditions for drug loading using ion-exchange resins Kyron T-114 and Kyron T-134 were evaluated. The microencapsulated drug-resin complexes were incorporated into oral dispersible tablets prepared using crospovidone as a superdisintegrant. The in vitro release profile of the optimized formulation of F4 was investigated, which showed linearity of Higuchi's rate kinetic equation. The shelf life of the optimized formulation was estimated to be 6.7 y, based on accelerated stability study data obtained. The physical and dissolution 3-month stability studies with the three formulations, F4, F5 and F6, showed better disintegration times.

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Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads

Cited by 39 publications

References 24 publications

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

Formulation, Development and Stability of Granisetron Sustained Release Oral Dispersible Tablets

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