Preparation and Evaluation of Microemulsion Containing Clove Oil and Peppermint Oil as Active Compound

Changmai, Arabinda; Adhikari, Atul; Dey, Biplab Kumar

doi:10.7897/2277-4572.084145

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Both ethanol and isopropanol provided CM with a particle size of less than 100 nm, of which the sizes were in the range of 10.24-62.44 and 8.81-77.56 nm, respectively. The particle size of less than 100 nm was also reported in CM formulations containing Tween 80isopropanol [6, 7], Tween 80-polyethylene glycol 400 [8] and Tween 80-ethanol [7,9] as surfactant systems. The PDI values of all preparations were less than 0.5; the values of more than 0.7 represent the broad size distribution of particles [13].…”

Section: Resultsmentioning

confidence: 79%

“…The mixture of surfactant (Tween 20) and co-surfactants (ethanol or isopropanol) at SR of 1:0.5, 1:1 and 1:2 were used to develop the phase diagram. The phase diagram was constructed using water titration technique [9]. Clove oil and SM were mixed at various weight ratios (0:10, 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, 9:1 and 10:0).…”

Section: Methodsmentioning

confidence: 99%

“…Generally, the size of ME ranged between 10-100 nm. In literature, CM had been formulated using several surfactant systems such as Tween 80-isopropanol [6,7], Tween 80polyethylene glycol 400 [8] and Tween 80-ethanol [7,9].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication, Characterization and Antioxidation Activity of Clove Oil- Loaded Microemulsions

Panomsuk

Nuntharatanapong

2022

Advances in Science and Technology

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Clove oil is a volatile oil that is extracted from clove buds of Syzygiumaromaticum. It was reported for antibacterial and antifungal activities. Microemulsions (ME) are a stable emulsion system composed of oil, surfactant mixture (SM, surfactant and co-surfactant) and water. In this study clove oil-loaded microemulsions (CM) were fabricated using Tween 20 as surfactant. Co-surfactants used in CM were ethanol and isopropanol. CM with different concentrations of clove oil (10-50% w/w) and SM (40-80% w/w) at Tween 20:co-surfactant ratios of 1:2 were formulated and characterized for their physico-chemical properties. All CM was clear liquid with thermodynamic stability. The size of all CM prepared from both ethanol and isopropanol was less than 100 nm. At lower oil and SM concentrations, the CM was o/w ME. When the concentration of oil or SM increased, the conductivity values decreased to less than 10 μS/cm indicating that the obtained CM was w/o ME. All CM formulations exhibited strong antioxidant activity as tested by the DPPH scavenging method (92.79 - 94.95% inhibition). Changing the type of co-surfactants (ethanol or isopropanol) or changing the oil to co-surfactant ratio did not significantly alter the antioxidant activity. Therefore, considering both physicochemical properties and antioxidant activity of CM, the CM containing 10% clove oil is the recommended formulation for commercial development.

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Section: Resultsmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

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Fabrication, Characterization and Antioxidation Activity of Clove Oil- Loaded Microemulsions

Panomsuk

Nuntharatanapong

2022

Advances in Science and Technology

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Quinoa (Chenopodium quinoa): Potential of the “Golden Grain” for Food and Nutritional Security in South Asia

Younis,

Sattar,

Suleman

2023

Neglected Plant Foods of South Asia

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Preparation and characterization of vemurafenib microemulsion based hydrogel using surface active ionic liquid

Neamah,

Al-Akkam

2024

PHAR

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Cancer is considered the second leading cause of death worldwide. Skin melanomas account for the highest mortality rate amongst all types of skin cancer. Systemic treatment with vemurafenib has a high rate of adverse effects, so attempts have been made to prepare a topical form of this drug. Microemulsions have been used to improve drug delivery to the skin. The microemulsions were prepared by dissolving vemurafenib in a mixture of peppermint oil and Smix, followed by the addition of water. The characteristics and effectiveness of surface-active ionic liquid-based vemurafenib microemulsions were characterised and evaluated in vitro. The vemurafenib microemulsions (CP5, CP7 and CP8) had droplet sizes in the microemulsion range (less than 200 nm), and they were used to prepare microemulsion-based hydrogels using HPMC K15M via the hot and cold method. The prepared microemulsion-based hydrogels were then evaluated. The microemulsion-based hydrogel GP5 exhibited higher skin deposition (45.4%) than the other hydrogels; thus, GP5 is a promising candidate for the topical treatment of melanoma by vemurafenib.

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Preparation and Evaluation of Microemulsion Containing Clove Oil and Peppermint Oil as Active Compound

Cited by 3 publications

References 3 publications

Fabrication, Characterization and Antioxidation Activity of Clove Oil- Loaded Microemulsions

Fabrication, Characterization and Antioxidation Activity of Clove Oil- Loaded Microemulsions

Quinoa (Chenopodium quinoa): Potential of the “Golden Grain” for Food and Nutritional Security in South Asia

Preparation and characterization of vemurafenib microemulsion based hydrogel using surface active ionic liquid

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