Preparation and Evaluation of Inclusion Complexes of Commercial Sunscreens in Cyclodextrins and Montmorillonites: Performance and Substantivity Studies

Coelho, Genoveva Luciana Negve; Dornelas, Camila Braga; Soares, Kelen Carine Costa; Santos, Elisabete Pereira dos; Vergnanini, André Luiz; Santos, Tereza Cristina dos; Rodrigues, Carlos Rangel; Castro, Helena C.; Dias, Luiza R.S.; Cabral, Lúcio Mendes

doi:10.1080/03639040701831769

Cited by 10 publications

(11 citation statements)

References 38 publications

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“…The results show that molecular volume is the major restrictive parameter of the inclusion process of sunscreens in CD. 20 Additionally, as illustrated in Figure 4, the peaks of OMC of the physical sunscreen formulation with cyclodextrin observed through the X-ray diffraction pattern were absent in the diffractogram of the complex. These results provide evidence of the inclusion of OMC in the β-CD cavity.…”

Section: Lipo/omc Complex Characterizationmentioning

confidence: 99%

“…32 The molecular volume of OMC, calculated by molecular modeling, was larger (367.53 Å 3 ) than the cavity of the β-CD (cavity volume = 262 Å 3 ). 20 The inclusion of OMC in α-CD (174 Å 3 ) produces low reproducibility and yield; however, the use of γ-CD (472 Å 3 ) produces an increase in the yield (20%). The results show that molecular volume is the major restrictive parameter of the inclusion process of sunscreens in CD.…”

Section: Lipo/omc Complex Characterizationmentioning

confidence: 99%

“…It was then purified with a 50% methanol:water solution and dried at 55°C for 30 minutes. 19,20 Complex formation was characterized by 1 H-nuclear magnetic resonance (NMR) spectroscopy (Gemini-200 MHZ; Varian, Palo Alto, CA) and X-ray diffractometry (Rigaku-Miniflex, Tokyo, Japan); complex yield was determined by UV spectrophotometer (UV-1601; Shimadzu, Kyoto, Japan). 20 The β-CD/OMC inclusion complex was manually incorporated in a cream with an OMC concentration of 8%.…”

Section: Formulation Containing β-Cd/omc (Formulation 3)mentioning

confidence: 99%

“…After that, 1.0 mL of ethanol:water (70:30) solution was added to the formulation, and a mass was formed. [18][19][20] The product (total mass 20 g) was then transferred to a ball mill (11 cm long and 8 cm diameter), containing 27 g of porcelain balls (average diameter 1 cm). The mixture was kept in the mill for 1 hour.…”

Section: Formulation Containing β-Cd/omc (Formulation 3)mentioning

confidence: 99%

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Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies

Monteiro¹,

Ozzetti²,

Vergnanini³

et al. 2012

IJN

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Purpose: Awareness of the harmful effects of ultraviolet radiation has led to the increasing use of sunscreens, thus, the development of safe and effective antisolar preparations is important. The inclusion of sunscreen molecules in different release systems, like liposomes (lipo) and cyclodextrins (CD) is therefore required. Methods: The in vivo sun protection factor (SPF), water resistance, and in vitro transdermal penetration test of octyl p-methoxycinnamate (OMC) in different dispersions, such as OMC encapsulated in liposomes (lipo/OMC), OMC encapsulated in β-cyclodextrins (β-CD/OMC), OMC encapsulated in both release systems (lipo/OMC and β-CD/OMC), and an OMC-free formulation were determined. Results: Although the formulation containing only the lipo/OMC system revealed high value of in vivo SPF (11.0 ± 1.3) and water resistance (SPF = 10.3 ± 2.2), the formulation containing both release systems (lipo/OMC + β-cyclodextrin/OMC) showed the best result in the in vivo SPF test (11.6 ± 1.6). In the penetration test, the formulation containing the lipo/OMC system had better performance, since a high amount of OMC in the epidermis (18.04 ± 1.17 µg) and a low amount of OMC in the dermis (9.4 ± 2.36 µg) were observed. These results suggest that liposomes interact with the cells of the stratum corneum, promoting retention of OMC in this layer. Conclusion: According to our study, the lipo/OMC system is the most advantageous release system, due to its ability to both increase the amount of OMC in the epidermis and decrease the risk of percutaneous absorption.

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Section: Lipo/omc Complex Characterizationmentioning

confidence: 99%

Section: Lipo/omc Complex Characterizationmentioning

confidence: 99%

Section: Formulation Containing β-Cd/omc (Formulation 3)mentioning

confidence: 99%

Section: Formulation Containing β-Cd/omc (Formulation 3)mentioning

confidence: 99%

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Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies

Monteiro¹,

Ozzetti²,

Vergnanini³

et al. 2012

IJN

View full text Add to dashboard Cite

show abstract

“…In fact, the inclusion into CDs is an appealing strategy to overcome the well-cited issues of sunscreens. This is the reason why inclusion has been attempted for several commercial sunscreens, such as PABA, EMC, 4-methylbenzylidene camphor (MBC), ethylhexyl dimethyl-PABA (EHD-PABA), B-4 and menthyl anthranilate [50]. All the complexes showed a higher UV filter capacity and an increased stability of the sunscreen molecule, thus reducing skin potential toxicity.…”

Section: Cyclodextrinsmentioning

confidence: 97%

The real value of novel particulate carriers for sunscreen formulation

Blasi

Schoubben

Giovagnoli

et al. 2011

Expert Review of Dermatology

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Solar radiation is a consolidated environmental risk factor in the development of non-melanoma skin cancer and is responsible for sunburn and skin aging. By consequence, the use of sunscreen products is considered the best approach for skin protection. Today, sunscreen products are based on conventional formulations, such as creams, milks or gels, which do not protect chemical ultraviolet filters from photodegradation and allow their systemic absorption. In this article, innovative systems, namely clays, cyclodextrins, polymer and lipid microparticles, are discussed as potential sunscreen carriers to be embedded in the aforementioned formulations. Their capability to improve sunscreen performances, to reduce their potential toxicity issues and to overcome formulation problems are examined also

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Cyclodextrins in the Cosmetic Field

Tarimci

2011

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine

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Preparation and Evaluation of Inclusion Complexes of Commercial Sunscreens in Cyclodextrins and Montmorillonites: Performance and Substantivity Studies

Cited by 10 publications

References 38 publications

Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies

Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies

The real value of novel particulate carriers for sunscreen formulation

Cyclodextrins in the Cosmetic Field

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