Preparation and evaluation of in-situ gels containing hydrocortisone for the treatment of aphthous ulcer

Sanjana, A; Ahmed, Mohammed Gulzar; Gowda, B.H. Jaswanth

doi:10.1016/j.jobcr.2021.02.001

Cited by 23 publications

(8 citation statements)

References 14 publications

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“…Methylcellulose gel is not irritant to the gingiva, safely applied intraorally, and raises the patient compliance. [ 14 ] Methylcellulose gel has constant stability at various temperatures and humidity degrees. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

“…The significantly shorter ulcer duration observed in the study group could be referred to the effect of CWP on wound healing in addition to the sustained release and high binding effect obtained from methylcellulose gel base, which ensures a prolonged contact period of CWP to be consistently released and absorbed by tissues up to the end of 8 h.[ 14 18 ]…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Novel Topical Camel Whey Protein Gel for the Treatment of Recurrent Aphthous Stomatitis

Elamrousy

Mortada

Shoukheba

2021

Journal of International Society of Preventive and Community Dentistry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Novel Topical Camel Whey Protein Gel for the Treatment of Recurrent Aphthous Stomatitis

Elamrousy

Mortada

Shoukheba

2021

Journal of International Society of Preventive and Community Dentistry

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“…The release mechanism was determined by fitting the data into the Korsmeyer-Peppas equation Mt/Ma = Ktn, where 'Mt/Ma' is the proportion of the drug released at time t,' 'K' is the kinetic constant, and 'n' is the release exponent that specified the process for releasing the drug. From the obtained data it was observed that the Korsmeyer-Peppas model was the best-fit kinetic release model [41].…”

Section: Drug Release Kineticsmentioning

confidence: 93%

Design and development of sodium alginate/ carboxymethyl cellulose in situ gelling system for gastroretentive delivery of lisinopril

PATIL¹,

PATIL²,

BHARADE³

et al. 2023

jrp

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Lisinopril is a potent ACE (angiotensin-converting enzyme) inhibitor used to treat hypertension and congestive heart failure. It exhibits 25% of low bioavailability. Hence, in the current study, the major objective was to increase the gastric transient time of lisinopril and develop in situ gel formulation for better absorption and modulating release behavior of lisinopril. Different formulations of lisinopril were prepared by using gelling polymers such as Carboxymethyl cellulose (CMC), pectin, and calcium carbonate. Sodium citrate was used to prevent gelation outside the gastric environment. The formulation was studied using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) to interpret the interaction between drugsand polymers. For optimization of in situ gelling system 3 2 full factorial design was employed to study the effect of independent variables, the concentration of CMC (X1) and concentration of sodium alginate (X2), on the dependent variables viscosity, and % drug content. Formulation (F5) containing 1.25% of sodium alginate, and 0.75% of CMC showed good gelling ability. The composition F5 was optimized on the basis of viscosity (5.03 Pa.s), drug content (94.06±1.0%), and cumulative drug release (95±0.73%) at 12 h. Floating in situ gelling system improved bioavailability and gastric transit time of lisinopril. A stability study indicated the absence of any noticeable change in the formulation. Thus, in situ gel formulation is a promising approach for gastro-retentive sustained delivery of lisinopril. These results ensure that the developed system is an alternative to conventional drug delivery systems and can enhance patient compliance.

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“…No significant changes in visual appearance, pH, viscosity, sol-gel transition, and % CDR were observed during the 3-month stability study shown in table 7. Hence the formulation can be found stable for at least a period of 3 mo [49].…”

Section: Stability Study Of Sf-ans-np-1 Loaded In Situ Gelmentioning

confidence: 96%

Silk Fibroin-Based Anastrozole Nanoparticle Loaded in Situ Injectable: Development and Characterization

2023

Self Cite

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Objective: The study aims to find a suitable method of developing silk fibroin-based anastrozole nanoparticles and formulate in situ injectables by loading the optimized nanoparticle formulation for the sustained release treatment of breast cancer. Methods: The nanoparticles were formulated utilizing two different methods, solvent change and precipitation approach using silk fibroin. Prepared nanoparticles characterized in terms of size, zeta potential, polydispersity, and entrapment efficiency. The chosen optimized formulation (SF-ANS-NPs-1) was subsequently analyzed for compatibility investigations by Fourier-transform infrared spectroscopy (FT-IR), thermal analysis, surface morphology, x-ray diffraction, transmission electron spectroscopy, cumulative drug release, and stability studies as per ICH guidelines. Followed by formulating and evaluating in situ injectable gel using pluronic F-127. Results: A particle size of 181.70±1.3 nm was reported by the optimized SF-ANS-NPs-1 formulation. FT-IR and thermal studies confirmed the compatibility of the drug with the polymers, and x-ray diffraction studies indicated crystalline nature. Surface morphology analysis indicated nano-size particle formation. A cumulative drug release (%CDR) of 94.15% was noted at the 168th hour. The results of the stability studies were indicated to be consistent over 90 d. In situ gel formulation showed desired spreadability, sol-gel transition temperature (37±0.5 ℃), viscosity (9.37±1.2 mPa·s), desired acidic pH, and a sustained release for 21 d (98.11%) with three months accelerated stability. Conclusion: The results suggested that the combination of anastrozole with silk fibroin in the form of nanoparticles and in situ gelling systems could be an undoubtedly effective delivery method for prolonging breast cancer therapy.

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Preparation and evaluation of in-situ gels containing hydrocortisone for the treatment of aphthous ulcer

Cited by 23 publications

References 14 publications

Evaluation of Novel Topical Camel Whey Protein Gel for the Treatment of Recurrent Aphthous Stomatitis

Evaluation of Novel Topical Camel Whey Protein Gel for the Treatment of Recurrent Aphthous Stomatitis

Design and development of sodium alginate/ carboxymethyl cellulose in situ gelling system for gastroretentive delivery of lisinopril

Silk Fibroin-Based Anastrozole Nanoparticle Loaded in Situ Injectable: Development and Characterization

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