Preparation and Evaluation of Extended-Release Nanofibers Loaded with Pramipexole as a Novel Oral Drug Delivery System: Hybridization of Hydrophilic and Hydrophobic Polymers

Limoee, Mazdak; Allahdad, Mohammad; Samadian, Hadi; Bahrami, Gholamreza; Pourmanouchehri, Zahra; Hosseinzadeh, Leila; Mohammadi, Bahareh; Vosoughi, Amirhossein; Forouhar, Kimia; Behbood, Leila

doi:10.1007/s12247-022-09625-1

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Limoee et al reported that the release rate of Pramipexole from hybrid crosslinked nanofibers was successfully controlled between 8 and 10 h, which is approximately the same time that the drug formulation travels from the mouth to the small intestine. It is worthwhile mentioning that the hybrid cross-linked nanofibers in this work were made of a mixture of a hydrophilic polymeric matrix (polyvinyl alcohol and carboxymethyl cellulose) and a hydrophobic polymer (polycaprolactone) [16]. Interestingly, the nature of the drug and the drug-polymer compatibility strongly affect the release behavior of the drug from nanofiber scaffolds [14,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

Le,

Nguyen,

Nguyen

et al. 2024

Beilstein J. Nanotechnol.

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Hydrophobic berberine powder (BBR) and hydrophilic BBR nanoparticles (BBR NPs) were loaded into an electrospun polylactic acid (PLA) nanofiber scaffold for modulating the release behavior of BBR in an aqueous medium. The BBR release from the BBR/PLA and BBR NPs/PLA nanofiber scaffolds was investigated in relation to their chemical characteristics, BBR dispersion into nanofibers, and wettability. The BBR release profiles strongly influenced the antibacterial efficiency of the scaffolds over time. When the BBR was loaded, the BBR/PLA nanofiber scaffold exhibited an extremely hydrophobic feature, causing a triphasic release profile in which only 9.8 wt % of the loaded BBR was released in the first 24 h. This resulted in a negligible inhibitory effect against methicillin-resistant Staphylococcus aureus bacteria. Meanwhile, the BBR NPs/PLA nanofiber scaffold had more wettability and higher concentration of BBR NPs dispersed on the surface of PLA nanofibers. This led to a sustained release of 75 wt % of the loaded BBR during the first 24 h, and consequently boosted the antibacterial effectiveness. Moreover, the cytotoxicity test revealed that the BBR NPs/PLA nanofiber scaffold did not induce any changes in morphology and proliferation of MA-104 cell monolayers. It suggests that the BBR/PLA and BBR NPs/PLA nanofiber scaffolds can be used in different biomedical applications, such as wound dressing, drug delivery systems, and tissue engineering, according to the requirement of BBR concentration for the desired therapeutic effects.

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Section: Introductionmentioning

confidence: 99%

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

Le,

Nguyen,

Nguyen

et al. 2024

Beilstein J. Nanotechnol.

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Polymeric Nanofibers for Drug Delivery Applications: A Recent Review

Duan

Chen

Guo

2022

J Mater Sci: Mater Med

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With the rapid development of biomaterials and biotechnologies, various functional materials-based drug delivery systems (DDS) are developed to overcome the limitations of traditional drug release formulations, such as uncontrollable drug concentration in target organs/tissues and unavoidable adverse reactions. Polymer nanofibers exhibit promising characteristics including easy preparation, adjustable features of wettability and elasticity, tailored surface and interface properties, and surface-to-volume ratio, and are used to develop new DDS. Different kinds of drugs can be incorporated into the polymer nanofibers. Additionally, their release kinetics can be modulated via the preparation components, component proportions, and preparation processes, enabling their applications in several fields. A timely and comprehensive summary of polymeric nanofibers for DDS is thus highly needed. This review first describes the common methods for polymer nanofiber fabrication, followed by introducing controlled techniques for drug loading into and release from polymer nanofibers. Thus, the applications of polymer nanofibers in drug delivery were summarized, particularly focusing on the relation between the physiochemical properties of polymeric nanofibers and their DDS performance. It is ended by listing future perspectives.

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An overview of nanofibers and microfibers for improved oral delivery of medicines: Challenges and advances

Ghasemiyeh,

Mohammadi-Samani,

Nokhodchi

2024

Journal of Drug Delivery Science and Technology

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Preparation and Evaluation of Extended-Release Nanofibers Loaded with Pramipexole as a Novel Oral Drug Delivery System: Hybridization of Hydrophilic and Hydrophobic Polymers

Cited by 4 publications

References 32 publications

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

Polymeric Nanofibers for Drug Delivery Applications: A Recent Review

An overview of nanofibers and microfibers for improved oral delivery of medicines: Challenges and advances

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