Preparation and Evaluation of Carboxymethyl Enset and Cassava Starches as Pharmaceutical Gelling Agents

Abstract

Boullawas purchased from the local Enset cultivating farmers in Durame, KambataTembaro Zone, South Nations Nationalities People Region (SNNPR), Ethiopia and cassava tubers were obtained from local cassava cultivating farmers in Sawula,

Ensete ventricosum: A Multipurpose Crop against Hunger in Ethiopia

“…is parameter affects the extrudability, spreadability, release of drug, and other physicochemical properties in gel formulations [72]. 6 e Scientific World Journal…”

“…Some poor properties of enset starch have not been improved by cross-linking. On the other hand, increased swelling powder and solubility and improved flow property and compactability have been obtained by acetylation and carboxymethylation substitution [72,76]. Higher degrees of enset starch substitution have resulted in high tensile strength and longer disintegration time that subsequently make the material suitable for sustained-release drug formulations [72,76].…”

Literature Review on Enset Starch: Physico-Chemical Properties and Pharmaceutical Applications

“…These improved properties suggest the potential application of CMS as a pharmaceutical gelling agent. A study was conducted by Gabriel and his coworkers to investigate carboxymethylated enset starch as pharmaceutical gelling agents 25 . Accordingly, nine different topical gel formulations of ibuprofen were prepared.…”

Self‐crosslinkable hydroxylated natural rubber/carboxymethyl starch blend and its properties

“…Starch is a naturally abundant polysaccharide which is available at low cost for preparation of various functional polymers. In general, starch is widely used not only in food but also in nonfood industrial applications such as food packaging, pharmaceutical, and thickener agent in the printing past of the reactive dyes . The modification of starch is one of the interesting processes for required properties such as low viscosity, low gelatinization temperature, and good solubility in cold water.…”

“…In general, starch is widely used not only in food but also in nonfood industrial applications such as food packaging, pharmaceutical, and thickener agent in the printing past of the reactive dyes. [11][12][13][14][15] The modification of starch is one of the interesting processes for required properties such as low viscosity, low gelatinization temperature, and good solubility in cold water. Recently, various chemical modifications of starches including carboxymethyl starch (CMS) [15][16][17][18] dialdehyde starch, 19 and starch acetate 20 have been of interests due to the insertion of bulky hydrophilic group on polysaccharide chains to reduce retrogradation (recrystallization) of starch and increase cold water solubility.…”