Preparation and Evaluation of Bioactivity of Porous Bioglass Tablets for Bone Tissue Regeneration

Kumar, R Rohith; Kumar, Sangeetha Ravi; Bhuvana, K. Periyasami

doi:10.28991/scimedj-2019-0103-1

Cited by 9 publications

(8 citation statements)

References 16 publications

(8 reference statements)

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“…PMMA leakage is a focus point to surgeons because neurological or spinal cord damage may cause by the situation [12,18,30]. Traditionally, PMMA is injected into the preset nail tunnel using a PVP device during laddering period, and then the screw is inserted [25].…”

Section: Discussionmentioning

confidence: 99%

“…These patients may have had many comorbidities and severe osteoporosis, which resulted in complex surgical procedures might not be tolerated. In one study of Huang et al [30], they observed the clinical outcomes of traditional PMMA augmentation technology in 28 cases of Kummell's disease. The operation time, blood loss and hospitalization time were 115.9 ± 10.0 minutes, 214.3 ± 17.5 ml and 7.6 ± 1.3 days respectively.…”

Section: Discussionmentioning

confidence: 99%

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Polymethylmethacrylate-augmented Cannulated Pedicle Screw Fixation for High-energy Vertebral Compression Fracture With Osteoporosis

Yaoyao¹,

Xiao²,

Xiang³

et al. 2021

Preprint

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Background: High-energy vertebral compression fracture (HVCFs) with osteoporosis has higher requirement for the stability of pedicle screw internal fixation system. However, few studies have involved the clinical outcome of cannulated pedicle screw to augment fixation with polymethylmethacrylate (PMMA) under this condition. This study aims to investigate the mid-term efficacy of bone cement-injectable cannulated pedicle screw (CICPS) in HVCFs with osteoporosis.Methods: Eighteen patients with HVCFs (T < -2.5) were underwent spinal fixation by CICPS from 2012 to 2017. The operation time, blood loss, and hospitalization time were recorded. Pain and functional recovery were evaluated by Visual Analog Scale VAS) and Oswestry Disability Index (ODI), respectively. X-ray films were taken to evaluate the loss of vertebral height, kyphosis angle, pedicle screw loosening, and bony fusion. Surgical related complications were also recorded.Results: The average follow-up time was 18.5 ± 8.7 months (range, 6-54 months). VAS and ODI scores indicated significant improvements in postoperative pain and activity function (P < 0.05). Comparing the last follow-up with the postoperative imaging findings, the loss of vertebral height and kyphosis angle was 3.4 ± 1.2 mm and 7.8 ± 3.8°, respectively. The rate of bone graft fusion was 100% while no cases were involved in screw loosening or extraction. 1 case of superficial infection, 2 cases of PMMA leakage, and 1 case of cerebrospinal fluid leakage were found.Conclusions: CICPS fixation using PMMA augmentation may suggest as a feasible surgical technique in osteoporotic patients with HVCFs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymethylmethacrylate-augmented Cannulated Pedicle Screw Fixation for High-energy Vertebral Compression Fracture With Osteoporosis

Yaoyao¹,

Xiao²,

Xiang³

et al. 2021

Preprint

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“…6,7 Conventional treatments of organ toxicity and chemotherapeutics for cancer prevention has many drawbacks that demand alternatives treatments or methods. 8–10 Therefore a need for natural compounds for preventing colon toxicity and search for chemopreventive agents appear.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

et al. 2021

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Colon cancer is a life-threatening disease all over the world and is linked to constant oxidative stress and inflammation. Epigallocatechin gallate (EGCG), is a naturally occurring flavone possessing health benefiting pharmacological properties including antioxidant, anti-inflammatory and free radical scavenging properties. Our study investigates the role of EGCG on N,N′-dimethylhydrazine (DMH), a toxic environmental pollutant, induced colon toxicity. To investigate the effect of EGCG, Wistar rats were given EGCG for 7 days at the two doses of 10 and 20 mg/kg body weight and DMH was injected on the seventh day in all the group rats except the control. Our results indicate that DMH administration increased the oxidative stress (MDA) and depleted the glutathione and antioxidant enzyme activities (SOD, CAT, GR, GST and GPx) which was significantly ameliorated by EGCG treatment. Additionally DMH treatment upregulated inflammatory markers expression (NF-κB, COX-2 and IL-6) and enhanced mucosal damage in the colon. EGCG treatment significantly reduced inflammation and restored the normal histoarchitecture of the colon. We can conclude from the present study findings that EGCG protects the colon from DMH toxicity through its antioxidant and anti-inflammatory potential.

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“…Among various current strategies that augment the biomechanical stability of internal xation, polymethylmethacrylate-augmented cannulated pedicle screw (CPS) is currently considered the best strategy due to its high strength and rapid solidi cation [3,4]. Although this strategy is widely accepted by researchers, complications are common to be observed which mainly including nerve compression symptoms, pulmonary embolism and nerve injury due to intraoperative cement leakage (CL) [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Risk Factor Analysis of Bone Cement Leakage for Polymethylmethacrylate-Augmented Cannulated Pedicle Screw Fixation in Spinal Degenerative Diseases

Liu¹,

Xiao²,

He³

et al. 2021

Preprint

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Background We investigated the risk factors of cement leakage (CL) for polymethylmethacrylate-augmented cannulated pedicle screw (CPS) in spinal degenerative diseases and provided technical guidance for clinical surgery. Methods This study enrolled 276 patients with spinal degenerative disease and osteoporosis who were augmented using CPSs (835 screws in total) from May 2011 to June 2018 in our hospital. The patients' age, sex, bone mineral density (BMD), diagnosis, augmented positions, number of CPS implanted, and CL during surgery were recorded. CL was observed by postoperative computed tomography (CT) and was classified by Yeom typing. Results A total of 74 (8.9%) CPSs in 64 patients leaked (23.2%), with 65 (87.83%), 3 (4.05%), and 6 (8.11%) screws showing Types S, B, and C leakage, respectively. CL was significantly correlated with the number and position of screws (P < 0.05), but not with sex, age, and BMD (P > 0.05). The position, number of CPSs, fracture, degenerative scoliosis, ankylosing spondylitis, and revision surgery were risk factors for CL (P < 0.05). Augmentation of the thoracic vertebral body, fracture, and ankylosing spondylitis were independent risk factors for Type S. Augmentation of the lumbar vertebral body, lumbar disc herniation, and lumbar spondylolisthesis were independent risk factors for Type B (P < 0.05). Conclusions CL has a high incidence in clinical practice. To avoid serious complications, high-risk factors for leakage should be addressed. Particularly, it is necessary to develop alternative solutions for the lack of holding force of internal fixation caused by CL during surgery.

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Preparation and Evaluation of Bioactivity of Porous Bioglass Tablets for Bone Tissue Regeneration

Cited by 9 publications

References 16 publications

Polymethylmethacrylate-augmented Cannulated Pedicle Screw Fixation for High-energy Vertebral Compression Fracture With Osteoporosis

Polymethylmethacrylate-augmented Cannulated Pedicle Screw Fixation for High-energy Vertebral Compression Fracture With Osteoporosis

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

Risk Factor Analysis of Bone Cement Leakage for Polymethylmethacrylate-Augmented Cannulated Pedicle Screw Fixation in Spinal Degenerative Diseases

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