Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients

Ishii, Naoko; Mizobuchi, Senri; Kawano, Yoshiro; Hanawa, Takehisa

doi:10.3390/pharmaceutics13111848

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…The idea of more individualized pharmacotherapy [1] has been developed for many years, but its significance has never been higher than it currently is [2]. The need to create personalized medicine [3] through the rational use of drugs by patients [4] in the correct dose is a subject of intense discussion since the heterogeneous nature of diseases [5] is the source of difficulties in the therapeutic intervention [6].…”

Section: Introductionmentioning

confidence: 99%

Innovative Methods for the Characterization of a Novel Pharmaceutical Adhesive for 3d Printing Drugs

SARBU¹

2022

FARMACIA

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3D printing has emerged in the technological context of prototyping. It offers the advantage of producing a unique, individualized object in a noticeably short timeframe and at a relatively low cost. Classical mass production methods provide a meagre price per unit delivered only if that product is made in large quantities. Hence, the cost of designing and executing models and templates divided by the number of units is low. The 3D printer does not need a fixed mold for producing drugs; it only uses data from mathematical software that can be adapted to different needs. This paper aims to address the lack of adhesion of the drug to the glass bed of the 3D printer. The adhesion to the glass bed of 3D printed parts is one of the most widespread current problems of 3D printing. This paper proposes the development of an adhesive to solve the problem of poor adhesion while maintaining the characteristics imposed by the rigors of the pharmaceutical field. Screening results showed that the polymer that, after complete drying, still maintains a sticky surface useful for adhesion was PVP. The other polymers did not readily dissolve in alcohol solutions, or they did not present any stickiness after drying, or the formulations were hard to dry (water-based formulations). The selected polymer was polyvinylpyrrolidone (PVP) for final formulations, and different concentrations and alcohol solutions were tested. Viscosity, spray pattern, and push force were investigated for each container spray with different formulations. The correlation between quantitative composition, the solvent used, and viscosity was evaluated to select the best overall formulation. RezumatImprimarea 3D a apărut în contextul tehnologic al prototipării. Oferă avantajul de a produce un obiect unic, individualizat într-un interval de timp semnificativ scurt și la un cost relativ scăzut. Metodele clasice de producție în masă oferă un preț slab pe unitate livrată numai dacă acel produs este fabricat în cantități mari. Prin urmare, costul de proiectare și execuție a modelelor și șabloanelor împărțit la numărul de unități este scăzut. Imprimanta 3D nu are nevoie de o matriță fixă pentru producerea medicamentelor; folosește doar date din software-ul matematic care pot fi adaptate la diferite nevoi. Această lucrare își propune să abordeze lipsa de aderență a medicamentului la patul de sticlă al imprimantei 3D. Aderența la patul de sticlă a pieselor imprimate 3D este una dintre cele mai răspândite probleme actuale ale imprimării 3D. Lucrarea de față propune dezvoltarea unui adeziv care să rezolve problema aderenței slabe păstrând în același timp caracteristicile impuse de rigorile domeniului farmaceutic. Rezultatele screening-ului au arătat că polimerul care, după uscarea completă, menține încă o suprafață lipicioasă utilă pentru aderență a fost PVP. Ceilalți polimeri nu s-au dizolvat ușor în soluții de alcool sau nu au prezentat nicio lipiciitate după uscare sau formulările au fost greu de uscat (formulări pe bază de apă). Polimerul selectat a fost polivinilpirol...

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Section: Introductionmentioning

confidence: 99%

Innovative Methods for the Characterization of a Novel Pharmaceutical Adhesive for 3d Printing Drugs

SARBU¹

2022

FARMACIA

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Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments

Burloiu,

Ozon,

Musuc

et al. 2024

Gels

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Photodynamic therapy (PDT) is an emerging treatment modality that utilizes light-sensitive compounds, known as photosensitizers, to produce reactive oxygen species (ROS) that can selectively destroy malignant or diseased tissues upon light activation. This study investigates the incorporation of two porphyrin structures, 5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl) porphyrin (P2.2.) and 5,10,15,20-tetrakis-(4-acetoxy-3-methoxyphenyl) porphyrin (P2.1.), into hydroxypropyl cellulose (HPC) hydrogels for potential use in topical photodynamic therapy (PDT). The structural and compositional properties of the resulting hydrogels were characterized using advanced techniques such as Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), atomic force microscopy (AFM), UV-Visible (UV-Vis) spectroscopy, and fluorescence spectroscopy. FTIR spectra revealed a slight shift of the main characteristic absorption bands corresponding to the porphyrins and their interactions with the HPC matrix, indicating successful incorporation and potential hydrogen bonding. XRD patterns revealed the presence of crystalline domains within the HPC matrix, indicating partial crystallization of the porphyrins dispersed within the amorphous polymer structure. TGA results indicated enhanced thermal stability of the HPC–porphyrin gels compared to 10% HPC gel, with additional weight loss stages corresponding to the thermal degradation of the porphyrins. Rheological analysis showed that the gels exhibited pseudoplastic behavior and thixotropic properties, with minimal impact on the flow properties of HPC by P2.1., but notable changes in viscosity and shear stress with P2.2. incorporation, indicating structural modifications. AFM imaging revealed a homogeneous distribution of porphyrins, and UV-Vis and fluorescence spectroscopy confirmed the retention of their photophysical properties. Pharmacotechnical evaluations showed that the hydrogels possessed suitable mechanical properties, optimal pH, high swelling ratios, and excellent spreadability, making them ideal for topical application. These findings suggest that the porphyrin-incorporated HPC hydrogels have significant potential as effective therapeutic agents for topical applications.

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Formulation and Development of Bioadhesive Oral Films Containing Usnea barbata (L.) F.H.Wigg Dry Ethanol Extract (F-UBE-HPC) with Antimicrobial and Anticancer Properties for Potential Use in Oral Cancer Complementary Therapy

et al. 2022

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Medical research explores plant extracts’ properties to obtain potential anticancer drugs. The present study aims to formulate, develop, and characterize the bioadhesive oral films containing Usnea barbata (L.) dry ethanol extract (F-UBE-HPC) and to investigate their anticancer potential for possible use in oral cancer therapy. The physicochemical and morphological properties of the bioadhesive oral films were analyzed through Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Atomic Force Microscopy (AFM), thermogravimetric analysis (TG), and X-ray diffraction techniques. Pharmacotechnical evaluation (consisting of the measurement of the specific parameters: weight uniformity, thickness, folding endurance, tensile strength, elongation, moisture content, pH, disintegration time, swelling rate, and ex vivo mucoadhesion time) completed the bioadhesive films’ analysis. Next, oxidative stress, caspase 3/7 activity, nuclear condensation, lysosomal activity, and DNA synthesis induced by F-UBE-HPC in normal blood cell cultures and oral epithelial squamous cell carcinoma (CLS-354) cell line and its influence on both cell types’ division and proliferation was evaluated. The results reveal that each F-UBE-HPC contains 0.330 mg dry extract with a usnic acid (UA) content of 0.036 mg. The bioadhesive oral films are thin (0.093 ± 0.002 mm), reveal a neutral pH (7.10 ± 0.02), a disintegration time of 118 ± 3.16 s, an ex vivo bioadhesion time of 98 ± 3.58 min, and show a swelling ratio after 6 h of 289 ± 5.82%, being suitable for application on the oral mucosa. They displayed in vitro anticancer activity on CLS-354 tumor cells. By considerably increasing cellular oxidative stress and caspase 3/7 activity, they triggered apoptotic processes in oral cancer cells, inducing high levels of nuclear condensation and lysosomal activity, cell cycle arrest in G0/G1, and blocking DNA synthesis. All these properties lead to considering the UBE-loaded bioadhesive oral films suitable for potential application as a complementary therapy in oral cancer.

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Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients

Cited by 3 publications

References 29 publications

Innovative Methods for the Characterization of a Novel Pharmaceutical Adhesive for 3d Printing Drugs

Innovative Methods for the Characterization of a Novel Pharmaceutical Adhesive for 3d Printing Drugs

Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments

Formulation and Development of Bioadhesive Oral Films Containing Usnea barbata (L.) F.H.Wigg Dry Ethanol Extract (F-UBE-HPC) with Antimicrobial and Anticancer Properties for Potential Use in Oral Cancer Complementary Therapy

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