Preparation and Evaluation of a Modified Mohs Paste Mixed with Zinc Oxide 10% Topical Oil-Based Ointment

Tsuruta, Minako; Miyoshi, Takanori; Tsuruyama, Moeko; Matsumoto, Saori; Yamashina, Takuya; Irie, Kenji; Matsuo, Naomi; Itonaga, Tomomi; Hiraki, Yoichi; Kawamata, Yosei

doi:10.1089/jpm.2017.0585

Cited by 3 publications

(2 citation statements)

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“…Tsuruta et al reported a mixture of Mohs' paste and zinc oxide 10% single ointment, which showed that the viscosity of modified Mohs' paste could be adjusted with glycerin. 7 The effect of prescription improvement of the Mohs' paste on the pharmacological effect was examined with reference to water absorbing property, and its tumor tissue invasion fixation depth as an indicator. 8 In the modified Mohs' technique, invasion fixation depth increased depending on application time.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Usefulness of a Modified Mohs' Technique and Topical Application of Zinc Oxide Powder for Treating Skin Infiltration Caused by Unresectable Malignant Tumors

Arima

Saito

Maeda

et al. 2021

Palliative Medicine Reports

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Background: Infiltrative lesions of the skin caused by unresectable malignant tumors reduce the quality of life of patients significantly due to the presence of bleeding, exudate, pain, and/or malodor. Objective: We compared the efficacy of a modified Mohs' technique and topical application of a starch powder containing zinc oxide as palliative treatments for skin lesions caused by unresectable tumors in our hospital. Design: This is a retrospective study. Settings/Subjects: This study included nine patients who were treated for skin-infiltrating lesions caused by unresectable malignant tumors at our hospital in Japan from April 2008 to December 2019. Measurements: Mohs' paste or zinc oxide powder (50%) was applied to the infiltrative skin lesions. Arterial embolization was performed before the application of the Mohs' paste for patients at risk for arterial hemorrhage. Patients were evaluated for pain, tumor size, bleeding, wound exudate, and malodor. Results: Both treatments were useful for alleviating symptoms, such as tumor size, local bleeding, malodor, and exudate in patients with unresectable malignant tumors. Pain was reduced in patients treated with Mohs' paste for 1 hour as compared with those treated for 24 hours. Conclusions: Effective management of skin infiltrative lesions can be achieved by using a modified Mohs' technique, topical application of starch powder containing zinc oxide, and arterial embolization to reduce the vascularization of the tumors.

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Section: Discussionmentioning

confidence: 99%

“…8 In the modified Mohs' technique, invasion fixation depth increased depending on application time. 7 The intended purpose of Mohs' paste application is to determine the appropriate use interval and contact time. The original Mohs' chemosurgery used a contact time of 24 hours for the purpose of removing the tumor.…”

Section: Discussionmentioning

confidence: 99%