Preparation and evaluation of a monolithic molecularly imprinted polymer for the chiral separation of neurotransmitters and their analogues by capillary electrochromatography

Huang, Baoyu; Chen, Yu‐Cheng; Wang, Guan-Ren; Liu, Chuen‐Ying

doi:10.1016/j.chroma.2010.12.054

Cited by 122 publications

(53 citation statements)

References 37 publications

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“…However, to remove the template from the resulting MIP, cleavage of the covalent bonds is required. In this type of material, the application becomes restricted, as there are not many functional monomers that can be used in the synthesis [144].…”

Section: Molecularly-imprinted Polymers (Mips)mentioning

confidence: 99%

Recent advances and future trends in new materials for sample preparation

Fumes

Silva

Andrade

et al. 2015

TrAC Trends in Analytical Chemistry

170

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Section: Molecularly-imprinted Polymers (Mips)mentioning

confidence: 99%

Recent advances and future trends in new materials for sample preparation

Fumes

Silva

Andrade

et al. 2015

TrAC Trends in Analytical Chemistry

170

View full text Add to dashboard Cite

“…[31] Recent studies have shown the use of monolithic molecularly imprinted polymer as a chiral support for the separation of neurotransmitters by capillary electrochromatography. [32] Two recent studies have combined MIP-brush coated SPME and MIP-sensor technique for ultra-trace analysis of dopamine. [33] In this report, a new commercially MIP-based SPE support devoted to the recognition of a broad range of catecholamines and metanephrines was studied.…”

Section: Introductionmentioning

confidence: 99%

Selective Solid-Phase Extraction of Catecholamines and Metanephrines From Serum Using a New Molecularly Imprinted Polymer

Claude

Morin

Denoroy

2014

Journal of Liquid Chromatography & Related Technologies

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& A new commercially molecularly imprinted polymer dedicated to the specific solid phase extraction of catecholamines and metanephrines has been tested for the extraction of neurotransmitters in serum samples. A protocol was developed especially for several aminergic neurotransmitters and metabolites (dopamine, 3-methoxytyramine, epinephrine, norepinephrine, normetanephrine, and serotonine).The serum was diluted in water (1=10, v=v), loaded on a cartridge filled with molecularly imprinted polymer and washed successively with water, methanol-water (15=85, v=v), and methanol. Analytes were then eluted with methanol-acetic acid (99=1, v=v). No matrix peak was observed on the chromatograms obtained by high performance liquid chromatography coupled with ultra-violet detection (281 nm). High selectivities were observed between imprinted and nonimprinted polymers. Extraction recoveries ranged from 64-98% (RSD <6%, n ¼ 4) depending on the type of analytes and linearity was assessed in the 0.30-0.90 lM concentration range by least squares regression (r 2 > 0.991).Then, large volumes of sample (8-40 mL) were loaded on the cartridge to evaluate the binding capacity of the cartridge. Increasing loaded sample volumes induced a decrease in extraction recovery, particularly for hydrophilic compounds. For a given elution recovery, higher preconcentration factors were achieved ($55) for less hydrophilic compounds (sample volume of 40 mL).

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“…As an artificial synthesis polymer, MIP has drawn more and more attention because of its unique advantages of ease preparation, low cost, good stability, high affinity and selectivity toward template molecule. For this reason, MIP can be used not only partially as a substitute of natural biomolecules but also as a substrateselective or separated material under harsh conditions, which enables itself to be applied into wide fields, such as biosensors, enzyme mimics, chiral separation, and solid phase extraction [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Recognition and determination of bovine hemoglobin using a gold electrode modified with gold nanoparticles and molecularly imprinted self-polymerized dopamine

Fan

Dai

et al. 2015

Microchim Acta

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A molecularly imprinted polymer (MIP) was prepared by self-polymerization of dopamine in the presence of bovine hemoglobin (BHb) and then deposited on the surface of an electrode modified with gold nanoparticles (AuNPs). Scanning electron microscopy, cyclic voltammetry, and differential pulse voltammetry were employed to characterize the modified electrode using the hexacyanoferrate redox system as an electroactive probe. The effects of BHb concentration, dopamine concentration, and polymerization time were optimized. Under optimized conditions, the modified electrode selectively recognizes BHb even in the presence of other proteins. The peak current for hexacyanoferrate, typically measured at + 0.17 V (vs. SCE), depends on the concentration of BHb in the 1.0×10 −11 to 1.0×10 −2 mg mL −1 range. Due to the ease of preparation and tight adherence of polydopamine to various support materials, the present strategy conceivably also provides a platform for the recognition and detection of other proteins.

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Preparation and evaluation of a monolithic molecularly imprinted polymer for the chiral separation of neurotransmitters and their analogues by capillary electrochromatography

Cited by 122 publications

References 37 publications

Recent advances and future trends in new materials for sample preparation

Recent advances and future trends in new materials for sample preparation

Selective Solid-Phase Extraction of Catecholamines and Metanephrines From Serum Using a New Molecularly Imprinted Polymer

Recognition and determination of bovine hemoglobin using a gold electrode modified with gold nanoparticles and molecularly imprinted self-polymerized dopamine

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