Preparation and Drug Release of Aspirin-Loaded PLGA-PEG-PLGA/Montmorillonite Microparticles

Liu, Hsin-Jiant; Chu, Hawn-Chung; Lin, Li‐Huei; Hsu, Shu-Yuan

doi:10.1080/00914037.2014.886238

Cited by 12 publications

(3 citation statements)

References 28 publications

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“…The incorporation of PLGA with MMT has been investigated by several groups for oral delivery of therapeutic agents using the mucoadhesive capability of MMT in crossing nanoparticles through GI barrier. − The ratio of MMT to PLGA in these studies is 10–40% (w/w). There is only one study reporting the use of PLGA-MMT as an iv drug delivery system in which the MMT/PLGA ratio is 0.042% .…”

Section: Resultsmentioning

confidence: 99%

“…The successful incorporation of MMT with polymeric materials via the intercalation process has led to the use of clay–polymer nanocomposites in many fields of applications − including drug delivery to a special target. , Poly( d , l -lactide- co -glycolide) (PLGA) is one of the most known biodegradable and biocompatible polymers used in drug targeting studies. Incorporation of PLGA with MMT for preparation of controlled release oral nanodrug delivery systems (NDDS) has been the subject in many studies. − The ratio of MMT to PLGA in these studies is 10–40% (w/w). According to the best of our knowledge, there is only one report on the preparation and characterization of PLGA-MMT NDDS for intravenous (iv) application by Sun et al in which the ratio of MMT to PLGA is designed as 0.042%.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the Kinetic Stability of Polymeric Nanomicelles (PLGA) Using Nano-Montmorillonite for Effective Targeting of Cancer Tumors

et al. 2022

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The toxic profile of chemical cross-linkers used in enhancing the stability of self-assembled nanomicelles made of amphiphilic polymeric materials hinders their use in clinical applications. This study was aimed to use the layered structure of Na-montmorillonite (MMT) as a stabilizer for nanomicelles made of poly(d,l-lactide-co-glycolide) (PLGA) amphiphilic polymer. The size of Na-MMT was reduced below 40 nm (nano-MMT) by processing in an attritor prior to its incorporation with PLGA. Hybrid PLGA nano-MMT (PM) nanoparticles (NPs) were prepared using dialysis nanoprecipitation. The size distribution was measured using dynamic light scattering (DLS). Loading 1250 μg of the model drug molecule curcumin to PM (PMC) resulted in obtaining 88 nm-sized particles, suitable for passive targeting of cancer tumors. The structure of nano-MMT and its position in PMC were investigated using FT-IR, differential scanning chalorimetry (DSC), XRF, XRD, ESEM, and EDAX assays, all of which showed the exfoliated structure of nano-MMT incorporated with both hydrophilic and hydrophobic blocks of PLGA. Curcumin was mutually loaded to PLGA and nano-MMT. This firm incorporation caused a serious extension in the release of curcumin from PMC compared to PLGA (PC). Fitting the release profile to different mathematical models showed the remarkable role of nano-MMT in surface modification of PLGA NPs. The ex vivo dynamic model showed the enhanced stability of PMC in simulated blood flow, while cytotoxicity assays showed that nano-MMT does not aggravate the good toxic profile of PLGA but improves the anticancer effect of payload. Nano-MMT could be used as an effective nontoxic stabilizer agent for self-assembled NPs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing the Kinetic Stability of Polymeric Nanomicelles (PLGA) Using Nano-Montmorillonite for Effective Targeting of Cancer Tumors

et al. 2022

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“…Aspirin from primary times of marketing approval became a drug effective for common inflammations, fever, and pain reduction. Liu et al [96] loaded aspirin in PLGA-PEG-PLGA copolymers while additionally checking the impact of including organic montmorillonite (o-MMT) in microspheres. MPs containing higher concentrations of montmorillonite show a faster rate of drug release despite the irregular effects of the first few hours.…”

Section: Microparticles Based On Amphiphilic Pla/peg and Plga/peg Cop...mentioning

confidence: 99%

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

et al. 2022

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The sustained release of pharmaceutical substances remains the most convenient way of drug delivery. Hence, a great variety of reports can be traced in the open literature associated with drug delivery systems (DDS). Specifically, the use of microparticle systems has received special attention during the past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability of both hydrophilic and lipophilic drug substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and their copolymers are among the most frequently used biodegradable polymers for encapsulated drugs. This review describes the current state-of-the-art research in the study of poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles and PLA-copolymers with other aliphatic acids as drug delivery devices for increasing the efficiency of drug delivery, enhancing the release profile, and drug targeting of active pharmaceutical ingredients (API). Potential advances in generics and the constant discovery of therapeutic peptides will hopefully promote the success of microsphere technology.

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The influence of hydrophilic mPEG segment on formation, morphology, and properties of PCL‐mPEG microspheres

Liu

Chen

et al. 2017

Adv Polym Technol

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This research displayed the differences of formation process, morphology, degradation, and release behaviors between PCL and PCL-mPEG microspheres. Lysozyme loaded microspheres were prepared by double emulsion evaporation method, and the double droplets transformation process was observed and compared under microscope. Microspheres morphology, in vitro degradation and release behaviors were evaluated by scanning electron microscope, gel permeation chromatography, and bicinchoninic acid protein assay kit. PCL-mPEG microspheres got a rough surface and the outer water phase penetrated into PCL-mPEG double droplet easier than PCL during the transformation, accompanied with a high broken percentage and size swelling. PCL-mPEG microspheres get a faster degradation/erosion rate than PCL microspheres, and the rate was in direct proportion to mPEG chain length. In vitro release analysis showed that PCL-mPEG microspheres get a faster release rate than PCL microspheres, and the rate was also in direct proportion to mPEG chain length.

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Preparation and Drug Release of Aspirin-Loaded PLGA-PEG-PLGA/Montmorillonite Microparticles

Cited by 12 publications

References 28 publications

Enhancing the Kinetic Stability of Polymeric Nanomicelles (PLGA) Using Nano-Montmorillonite for Effective Targeting of Cancer Tumors

Enhancing the Kinetic Stability of Polymeric Nanomicelles (PLGA) Using Nano-Montmorillonite for Effective Targeting of Cancer Tumors

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

The influence of hydrophilic mPEG segment on formation, morphology, and properties of PCL‐mPEG microspheres

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