Preparation and drug release behavior of pH-responsive bovine serum albumin-loaded chitosan microspheres

Zou, Xue; Zhao, Xiaowen; Ye, Lin; Wang, Qi; Li, Hao

doi:10.1016/j.jiec.2014.06.012

Cited by 86 publications

(37 citation statements)

References 36 publications

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“…Its properties depend on the deacetylation degree. It is soluble for a low pH values, when the amino groups are protonated and they can react with polyanions (alginates, acacia gum, carrageenans, tripolyphosphate) forming complex coacervate hydrogels (Dima et al, 2014;Dutta, Tripathi, Mehrotra, & Dutta, 2009;Zou, Zhao, Ye, Wang, & Li, 2015).…”

Section: Introductionmentioning

confidence: 99%

The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules

et al. 2016

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Section: Introductionmentioning

confidence: 99%

The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules

et al. 2016

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“…The 5-FU release mechanism from PVA/PVP and CNT-50 hydrogels was determined with 4 different release kinetic models, which are zero-order, first-order, Higuchi and Korsmeyer-Peppas kinetic models [35,36]. The zero-order kinetic model describes the systems, which are not related to the drug concentration while the first-order kinetic model defines the systems, which depend on drug concentration.…”

Section: Mathematical Modelingmentioning

confidence: 99%

Carbon nanotube based polyvinylalcohol-polyvinylpyrolidone nanocomposite hydrogels for controlled drug delivery applications

Irmak

2017

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY a - Applied Sciences and Engineering

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Controlled drug release systems present a significant alternative to the conventional drug dosages providing drug release for prolonged time periods. Nanocomposite hydrogels offer an important potential for drug release with enhanced physicochemical properties. In this study, the preparation of carbon nanotube (CNT)-based Polyvinylalcohol-Polyvinylpyrolidone (PVA/PVP) nanocomposite hydrogels namely, CNT-25, CNT-50 and CNT-100 were succeedded via the freeze/thawing method with the addition of different amounts of CNT. The nanocomposite hydrogels were characterized by swelling tests, SEM, FTIR, DSC and BET measurements. It was determined that CNT-50 was the most suitable hydrogel for drug release studies having better morphological properties with homogenous distribution of CNT throughout the polymeric nanocomposite matrix. The release of 5-fluororacil (5-FU) as a model drug was investigated in-vitro. The release of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels was exhibited controlled release for one week at pH 7.4. The amount of released 5-FU was effectively increased with the addition of CNT into the hydrogel matrix. Korsmeyer-Peppas model was well fitted for determining the release mechanism of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels corresponding the combination of diffusion of the drug and the dissolution of polymer chains.

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“…In general, increased concentrations of the polymer conjugate (2.5 mg/mL) and TPP (0.3%) with reduced PVA concentration (0.55%) lead to the synthesis of a reduced average particle size (F11 = 56.28 nm). This could be as a result of strong electrostatic interactions between the BSA/endostatin molecules and the increased positively charged amino groups of CHT at higher concentration, as the main component in the grafted polymer conjugate [25]. Furthermore, increased electrostatic interaction between the negative charge of TPP as a polyanionic agent at higher concentration and the positively charged amino group of CHT could possibly account for the reduction in nanoparticle size [25].…”

Section: Confirmation Of the Physicochemical Properties Andmentioning

confidence: 99%

“…This could be as a result of strong electrostatic interactions between the BSA/endostatin molecules and the increased positively charged amino groups of CHT at higher concentration, as the main component in the grafted polymer conjugate [25]. Furthermore, increased electrostatic interaction between the negative charge of TPP as a polyanionic agent at higher concentration and the positively charged amino group of CHT could possibly account for the reduction in nanoparticle size [25]. Thus, the optimized endostatin-loaded nanoparticles were prepared at CHT concentration of 2.5 mg/mL and have an average hydrodynamic size of 100.6 nm ( Figure 4).…”

Section: Confirmation Of the Physicochemical Properties Andmentioning

confidence: 99%

Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

Adeyemi

Choonara

Kumar

et al. 2017

Journal of Nanomaterials

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The aim of this study is to effectively enhance antitumor activities of endostatin by preparing polymeric nanocarriers. NMR and FT-IR spectra confirmed the successful grafting of the CHT-g-PEI and CHT-g-PEI-PEG-NH 2 conjugates. SEM micrographs confirmed the shape of endostatin-loaded nanoparticles to be spherical while both TEM and zeta size results showed nanoparticle's average size to be 100.6 nm having a positively charged surface with zeta potential of 7.95 mV. The concentrations of CHT and TPP as well as the changing pH conditions account for the increased swelling pattern of endostatin-loaded nanoparticles and influenced endostatin release in vitro. PEI increased the overall amine protonation while PEG aggravated endostatin encapsulation and release. Nanoparticles swell and release endostatin at acidic tumor pH of 6.8 compared to physiological pH of 7.4. The native CHT-g-PEI-PEG-NH 2 conjugate showed high cytocompatibility above 80% cell viability across tested formulations. Endostatin-loaded nanoparticles showed a significant reduction in cell viability across tested formulations, with 5.32% cell death at 125 g/mL and 13.36% at 250 g/mL following 24 hours' incubation period. Interestingly, more than a fourfold (61.68%) increment in cytotoxicity was observed at nanoparticle concentration of 1000 g/mL. It was concluded that CHT-g-PEI-PEG-NH 2 is an effective cargo for endostatin delivery with antiangiogenic effect in squamous cell carcinoma.

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Preparation and drug release behavior of pH-responsive bovine serum albumin-loaded chitosan microspheres

Cited by 86 publications

References 36 publications

The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules

The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules

Carbon nanotube based polyvinylalcohol-polyvinylpyrolidone nanocomposite hydrogels for controlled drug delivery applications

Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

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