Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of Griseofulvin

Chiou, Win L.; Riegelman, Sidney

doi:10.1002/jps.2600581218

Cited by 258 publications

(133 citation statements)

References 14 publications

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“…In the melting process, the molecular mobility of carrier is high enough to change the drug's incorporation 36 . A common adaptation to the melting phase consists of suspending the active drug in a previously melted carrier, instead of using both drug and carrier in the melted state, reducing, therefore, the process temperature .To cool and solidify the melted mixture, several processes such as ice bath agitation 37,38 , stainless steel thin layer spreading followed by a cold draught 39 , solidification on petri dishes at room temperature inside a dessicator 40 , spreading on plates placed over dry ice 41 , immersion in liquid nitrogen or stored in a dessicator 42,43 were used.…”

Section: Fig 4: Manufacturing Processes Used To Produce Solid Dispermentioning

confidence: 99%

“…Consequently, if the drugs are not completely released in the gastrointestinal area, they will have a low bioavailability 11,12 . Therefore, one of the major current challenges of the pharmaceutical industry is related to strategies that improve the water solubility if drug 6,14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…By improving the drug release profile of these drugs, it is possible to enhance their bioavailability and reduce side effects 11,15,[16][17][18] . Solid dispersions are one the most successful strategic approach to improve drug release of poorly soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2010

IJPSR

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The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and various stability problems. It can be carried out by reducing drug particle size to the absolute minimum, and hence improving drug wet-ability, bioavailability may be significantly improved. Solid dispersion of drugs was generally produced by melt or solvent evaporation methods. Recently, surfactants have been included to stabilize the formulations, thus avoiding drug recrystallization and potentiating their solubility. New manufacturing processes to obtain solid dispersions have also been developed to reduce the drawbacks of the initial process. In this review, it is intended to discuss the eminent approach to improve the solubility or the dissolution rate and recent revival has been discussed.

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Section: Fig 4: Manufacturing Processes Used To Produce Solid Dispermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2010

IJPSR

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“…For drugs whose bioavailability is limited due to poor aqueous solubility (as in BSC class II drugs), the improvement in solubility may lead to enhanced bioavailability [8][9][10][11] . Solid dispersion represents a useful pharmaceutical technique for increasing the dissolution, absorption, and therapeutic efficacy of drugs in dosage forms [12][13] . The properties, performance, and practical applications of solid dispersions depend on factors such as: (a) the method of preparation, (b) composition, (c) selection of a suitable carrier, and (d) physicochemical properties of the drug 1,14 .…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Solid Dispersion of Modafinil Using Peg6000 as Hydrophilic Carrier for Improvement of Dissolution Profile

Kathiriya¹

2014

J. Drug Delivery Ther.

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“…[1][2][3] In general, solid dispersion is prepared with water soluble polymer, such as polyethylene glycol (PEG) 4) or polyvinylpyrrolidone (PVP) 5) as carrier, to disperse the drug molecules in the polymer matrix. Recently, the porous materials were also used as a carrier to disperse the drug molecules in the pores.…”

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confidence: 99%

Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles

Takeuchi

Nagira

Tanimura

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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We attempted to make the rapidly dissolving tablet (Tab) containing solid dispersion particles (SD) with indomethacin (IMC) and porous silica (Sylysia350) as carrier prepared by using spray-drying technique. Rapidly dissolving tablet was formulated with mannitol as a diluent and low substituted hydroxypropylcellulose (L-HPC) or partly pre-gelatinized starch (PCS) as a disintegrant. The percent dissolved from Tab (SD) was higher than that of tablet containing physical mixture (PM) at 20 min. Nearly 100% of drug in Tab (SD) was dissolved within 60 min, while the drug dissolution of Tab (PM) was not completed at the same time period. In addition, the tensile strength of Tab (SD) was much higher than that of Tab (PM). Adding L-HPC in Tab (SD) (Tab (SD-L-HPC)), the percent dissolved from Tab (SD-L-HPC) at 5 min became much higher than that from Tab (SD). The dissolution profile of IMC from Tab (SD-L-HPC) was almost the same irrespective of the compression pressure, while the tensile strength of tablet increased with increasing the compression pressure. In comparing the compaction property of these tablets by observing the ratio of residual die wall pressure (RDP) to maximum die wall pressure (MDP) (RDP/MDP), it was found that addition of L-HPC in the tablet formulation improved compactibility. In case that PCS was formulated as disintegrant, Tab (SD-PCS), similar improvement in the dissolution profile and tensile strength was observed, though the dissolution rate of IMC from Tab (SD-PCS) was slightly lower than that from Tab (SD-L-HPC) irrespective of the compression pressure.

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Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of Griseofulvin

Cited by 258 publications

References 14 publications

Untitled

Untitled

Preparation and Characterization of Solid Dispersion of Modafinil Using Peg6000 as Hydrophilic Carrier for Improvement of Dissolution Profile

Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles

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