Preparation and detailed structural characterization of Penicillin G imprinted polymers by PALS and XPS

Söylemez, Meshude Akbulut; Güven, Olgun

doi:10.1016/j.radphyschem.2019.02.050

Cited by 13 publications

(15 citation statements)

References 31 publications

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“…The membranes were incubated in 2 mL Penicillin G solutions with a various concentration in the range of 0.5-50 ppm. The concentration of Penicillin G before and after incubation was analyzed by employing a UV-vis Varian Cary100 spectrophotometer at a maximum absorption wavelength of 216 nm [11]. The number of repetition of the analyses was three.…”

Section: Investigation Of Binding Properties Of Membranesmentioning

confidence: 99%

“…The solution had been kept overnight at 4 o C. EGDMA (5.00 mmol) and 8 mL of DMF were added. The ratio of MAA to penicillin G was kept as 4:1 [11]. The formation of pre-polymerization complex between template and functional monomers and the synthesis of penicillin G imprinted membranes were illustrated in Fig.…”

Section: Preparation Of Penicillin G Imprinted Membranesmentioning

confidence: 99%

“…SB of the MIM was determined as 3.27 µg/g polymer for penicillin G while this value obtained as 0.83 and 0.51 µg/g polymer for penicillin V and amoxicillin, respectively. Because of the complete complement of the binding sites in terms of shape, size and unique interaction between the template molecule penicillin G and the imprinted membrane, the highest SB value was obtained for the template molecule [11].…”

Section: Specific Selectivity Of Membranesmentioning

confidence: 99%

“…[8,9]. The production methods includes synthesis of nanopolymers by emulsion polymerization [9], surface imprinting onto various support materials like magnetic nanoparticles [10] or non-woven fabrics [11]. Unfortunately,…”

mentioning

confidence: 99%

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Selective Removal of Penicillin G from Environmental Water Samples by Using Molecularly Imprinted Membranes

Söylemez

2020

Hittite J. Sci. Eng.

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S ince its discovery, penicillin G has been useful for the treatment of infectious diseases in humans and animals. This compound is one of the most widely used drugs among antibiotics. Unfortunately, there is a continuous release of antibiotics due to the widespread and overuses of this family of the drug in some certain places such as hospitals and farms. Release of antibiotics to environmental waters is a crucial problem for human health. The residues of antibiotics were detected in industrial and municipal wastewater, and also surface and groundwater samples [1][2][3][4]. The residues of antibiotics in environmental waters may cause the development of antibiotic resistance [5]. The recognition and removal of the antibiotics from environmental water are necessary to protect public health by using easy, compatible, cheap and reliable materials.There are several sensing and recognition systems for Penicillin G prepared by utilizing molecularly imprinting method [6][7][8]. Most of them are related by detecting of antibiotics from complex matrices such as food and food derivatives like milk, chicken, etc. [8,9]. The production methods includes synthesis of nanopolymers by emulsion polymerization [9], surface imprinting onto various support materials like magnetic nanoparticles [10] or non-woven fabrics [11]. Unfortunately,

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Section: Investigation Of Binding Properties Of Membranesmentioning

confidence: 99%

Section: Preparation Of Penicillin G Imprinted Membranesmentioning

confidence: 99%

Section: Specific Selectivity Of Membranesmentioning

confidence: 99%

mentioning

confidence: 99%

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Selective Removal of Penicillin G from Environmental Water Samples by Using Molecularly Imprinted Membranes

Söylemez

2020

Hittite J. Sci. Eng.

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“…There are two main reasons: First, since light is directly responsible for radical generation, the temperature can be set to low values, which protects temperature-sensitive, noncovalent interactions between template and functional monomers, thus improving the imprinting efficiency and the MIP’s affinity for its target . Also, the use of low temperatures (e.g., 0 to 20 °C) , is preferred to avoid degradation of sensitive analytes such as proteins and, in some cases, to suppress undesired side reactions . Second, owing to their nature, photochemical processes allow spatiotemporal and intensity control over the polymerization reaction.…”

Section: Introduction: Molecularly Imprinted Polymersmentioning

confidence: 99%

Photopolymerization and Photostructuring of Molecularly Imprinted Polymers

Paruli

Soppera

Haupt

et al. 2021

ACS Appl. Polym. Mater.

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Over the past few decades, molecularly imprinted polymers (MIPs) have become extremely attractive materials for biomimetic molecular recognition due to their excellent affinity and specificity, combined with robustness, easy engineering, and competitive costs. MIPs are synthetic antibody mimics obtained by the synthesis of 3D polymer networks around template molecules, thus generating specific binding cavities. Numerous efforts have been made to improve the performances and the versatility of MIPs, with a special focus on ways to control their size, morphology, and physical form for a given application. Gaining control over these parameters has allowed MIPs to adopt a defined micro- and nanostructure, providing access to nanocomposites and micro/nanosystems, with fine-tuned properties, which become critical for modern applications ranging from chemical sensing to bioimaging and medical therapy. In this rich and complex context, light as a cheap and versatile source of energy has emerged as a powerful tool for structuring MIPs. This review presents the most recent advances on structuring MIPs at the nano/microscale, using light as a stimulus to trigger the polymerization process. Thus, after a general introduction on radical polymerization of MIPs, with a special emphasis on photopolymerization by UV and visible light, the reader will be presented with ways of structuring MIPs by processes that are inherently spatially confined, such as localized photopolymerization and lithographic techniques, supported by representative examples and complemented with a final outlook on future trends in this field.

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Synthesis and characterization of tetracycline‐imprinted membranes: A detailed positron annihilation lifetime spectroscopy investigation

Söylemez

2021

J of Molecular Recognition

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Molecularly imprinted thin membranes for selective removal of tetracycline from real water samples were prepared using the radiation-induced polymerization method. The chemical and physical characterization of the membranes was conducted by FTIR, XPS, AFM and SEM analyses. The effect of the template on the size and the size distribution of the pores in the membrane structure was investigated by positron annihilation lifetime spectroscopy (PALS) experiments. The presence of the template molecule causes the formation of larger cavities, which have a strong correlation to the molecular size of the template molecule. The density of the free volume holes in the imprinted network shows a significant increase due to the presence of the template molecule. The binding performances of the membranes were tested against various factors such as pH, time and initial concentration of template molecules. The specific selectivity of the membranes was investigated by cross-reactivity experiments. The binding capacity of the imprinted membranes was obtained at 14.5 μmol g −1 , with the highest imprinting factor (2.84) for tetracycline. The imprinting factor was obtained at 1.44, 1.25 and 1.57 for oxytetracycline hydrochloride, doxycycline hyclate and chlortetracycline, respectively. The binding capability of the imprinted membranes in real water samples was promising for the application of the membranes as a filter material for removal of tetracycline with high binding capacity. Tetracycline binding percentage of the membranes was determined at 92.4, 81.1., 75.0 and 68.7 for ultra-pure water, tap water and natural water samples collected from different sources, respectively.

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Preparation and detailed structural characterization of Penicillin G imprinted polymers by PALS and XPS

Cited by 13 publications

References 31 publications

Selective Removal of Penicillin G from Environmental Water Samples by Using Molecularly Imprinted Membranes

Selective Removal of Penicillin G from Environmental Water Samples by Using Molecularly Imprinted Membranes

Photopolymerization and Photostructuring of Molecularly Imprinted Polymers

Synthesis and characterization of tetracycline‐imprinted membranes: A detailed positron annihilation lifetime spectroscopy investigation

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