Preparation and degradation characteristics of biodegradable elastic poly (1,3-trimethylene carbonate) network

Liu, Xiliang; Liu, Song; Li, Kaiqi; Feng, Shaomin; Fan, Youkun; Peng, Lizeng; Wang, Xin; Chen, Dongliang; Xiong, Chengdong; Bai, Wei; Zhang, Lifang

doi:10.1016/j.polymdegradstab.2021.109718

Cited by 11 publications

(6 citation statements)

References 51 publications

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“…Liu et al prepared PTMC networks by vacuum gamma radiation using trimethylolpropane triacrylate (TMPTA), pentaerythritol triacrylate (PETA) and pentaerythritol tetraacrylate (PET4A) as crosslinking agents to improve mechanical properties and creep resistance. 23 The maximum tensile strength of the PTMC cross-linked network can reach 25.95 ± 2.20 MPa. However, its degradation rate is slow and it still retains more than 90% of its mass after 12 weeks of in vitro enzymatic degradation (the degradation performance of scaffolds is also recorded in Table 2, which also includes the degradation performance of scaffolds in other studies).…”

Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 96%

“…Poly (1,3-trimethylcarbonate) (PTMC) is a flexible, biodegradable and amorphous polymer synthesized by ring-opening polymerization of 1,3-trimethylcarbonate. Because PTMC promotes surface erosion through enzymes, it can still maintain mechanical strength and elastomeric properties during degradation, 22,23 but its initial mechanical strength is generally low. In addition, PTMC does not produce acidic byproducts when degraded, which has been recognized as a great advantage in tissue reconstruction.…”

Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 99%

“…Synthetic polymers have much improved mechanical properties as compared to natural polymer materials, and scaffolds composed of these materials will have mechanical characteristics more akin to natural cartilage. Common synthetic polymers include polylactide (PLA), polycaprolactone (PCL), 106 polyethylene glycol (PEG), 107 polyglycolic acid (PGA), 108 polyvinyl chloride (PVC), polyethylene (PE), nylon, silicone rubber, poly(1, 3-trimethylcarbonate) (PTMC), 23 polyurethane (PU), 58 etc. Researchers have focused primarily on the first two types of artificial polymers in CTE because of their biocompatibility and material degradability.…”

Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 99%

“…19–21 This functionality is largely dependent on adequate mechanical and biological scaffold properties. 22–24 Therefore, imitation and reconstruction of multi-layered cartilaginous ECM is a key issue for cartilaginous repair. 25…”

Section: Introductionmentioning

confidence: 99%

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From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

Zhang,

Wang,

et al. 2023

Phys. Chem. Chem. Phys.

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Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 96%

Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 99%

Section: The Biomaterials Selection For 3d-printed Cte Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

Zhang,

Wang,

et al. 2023

Phys. Chem. Chem. Phys.

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“…Compared with chemical cross-linking, irradiation cross-linking allows PTMC to be molded before cross-linking. In particular, gamma- and electron beam irradiation enables rapid cross-linking of the molded PTMC ( Liu et al, 2021a ; Liu et al, 2021b ; Jozwiakowska et al, 2011 ), and the cross-linked PTMC also has a slow degradation rate due to the formation of the cross-linked network ( Bat et al, 2009 ; Bat et al, 2010a ; Liu et al, 2021c ), which can significantly improve the erosion resistance of PTMC. Grijpma et al reported that biodegradable elastomeric PTMC-BCNs could be efficiently formed by gamma irradiation of the linear polymer in the presence of pentaerythritol triacrylate (PETA), and the enzymatic erosion rates of the networks could be decreased from 12.0 ± 2.9 to 3.0 ± 1.6 µm/day ( Bat et al, 2010b ).…”

Section: Introductionmentioning

confidence: 99%

In vitro enzymatic degradation of the PTMC/cross-linked PEGDA blends

Li,

Lin,

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Poly(1,3-trimethylene carbonate) (PTMC) is a flexible amorphous polymer with good degradability and biocompatibility. The degradation of PTMC is critical for its application as a degradable polymer, more convenient and easy-to-control cross-linking strategies for preparing PTMC are required.Methods: The blends of poly(trimethylene carbonate) (PTMC) and cross-linked poly(ethylene glycol) diacrylate (PEGDA) were prepared by mixing photoactive PEGDA and PTMC and subsequently photopolymerizing the mixture with uv light. The physical properties and in vitro enzymatic degradation of the resultant PTMC/cross-linked PEGDA blends were investigated.Results: The results showed that the gel fraction of PTMC/cross-linked PEGDA blends increased while the swelling degree decreased with the content of PEGDA dosage. The results of in vitro enzymatic degradation confirmed that the degradation of PTMC/cross-linked PEGDA blends in the lipase solution occurred under the surface erosion mechanism, and the introduction of the uv cross-linked PEGDA significantly improved the resistance to lipase erosion of PTMC; the higher the cross-linking degree, the lower the mass loss.Discussion: The results indicated that the blends/cross-linking via PEGDA is a simple and effective strategy to tailor the degradation rate of PTMC.

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Synthesis and Characterization of Novel Radiopaque Polycarbonate

Fan

Shao

Liu

et al. 2022

Macromol. Rapid Commun.

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Polymeric materials implanted in the human body are usually invisible under X-ray, and the mixing of heavy metal salts into polymeric materials by physical compounding often poses compatibility problems. A new iodine-containing cyclic carbonate monomer, 4-iodo-N-(2-oxo-1,3-dioxan-5-yl)benzamide (IBTMC), is synthesized, which has a degradable carbonate group as its basic structural unit and iodine atoms attached to the side chain in the form of covalent bonds. The ring-opening polymerization of IBTMC is achieved at room temperature under the catalysis of the solid superbase 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). The structure and X-ray developing ability of the synthesized polycarbonate are characterized by 1 H-NMR, X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDS), Gel Permeation Chromatography (GPC), and micro-computed tomography (Micro-CT). The iodine atoms remain bound to the polymer as covalent bonds after a series of reactions and exhibit a high level of X-ray opacity. In vitro degradation experiments of the polymer prove that the polymer is degradable.

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Preparation and degradation characteristics of biodegradable elastic poly (1,3-trimethylene carbonate) network

Cited by 11 publications

References 51 publications

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

In vitro enzymatic degradation of the PTMC/cross-linked PEGDA blends

Synthesis and Characterization of Novel Radiopaque Polycarbonate

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