Preparation and crystallographic studies of a new mercuric salicylaldimine complex for fabrication of microscaled and nanoscaled mercuric sulfide as antimicrobial agents against human pathogenic yeasts and filamentous fungi

Abstract

The new mercuric complex [Hg(HL) 2 Cl 2 ] incorporating salicylaldimine ligand (HL = 2-((pyridin-3-ylimino)methyl)phenol) was fabricated where the ligand molecules behaved in a monodentate manner via their pyridine nitrogen atoms. In addition to elemental characterization, X-ray crystallographic studies of the complex revealed its packing in a monoclinic crystal system (space group: I2/a, a = 13.4276(2) Å, b = 6.20950(10) Å, c = 27.7530 (4) Å, α = γ = 90 , and β = 98.1610(10)). Hydrothermal treatment of [Hg(HL) 2 Cl 2 ] with thioacetamide afforded HgS microparticles (HgS μPs; Brunauer-Emmett-Teller [BET] surface area = 6.205 m 2 /g, diameter = 196.53-259.13 nm, and average size = 213.27 nm), whereas these microparticles were transformed to nanoscaled HgS particles (HgS NPs; BET surface area = 14.380 m 2 /g, diameter = 58.87-90.56 nm, and average size = 72.78 nm) by the action of ultrasonication. The as-prepared HgS, HgS NPs in particular, afforded remarkable microbicidal activity against eight strains of filamentous and unicellular human pathogenic fungi and yeasts in comparison with cycloheximide. Remarkably, Aspergillus terreus grew up to 34.7 ± 1.88 mm in the absence of any fungicide, but HgS μPs, HgS NPs, and cycloheximide limited the fungal growth to 26 ± 0.94, 12.33 ± 1.6, and 28.3 ± 1.7 mm after incubation for 6 days. Besides, inhibition of Rhodotorula glutinis was of 7.6 ± 0.01 × 10 7 CFU/ml in control sample, but experiments included HgS μPs, HgS NPs, and cycloheximide limited the colony-forming units of R. glutinis to 4.2 ± 0.01 × 10 7 , 3.5 ± 0.02 × 10 7 , and 5.9 ± 0.05 × 10 7 CFU/ml.

The optimal concentration of silver nanoparticles in sterilizing fish skin grafts

“…Infections caused by bacteria, fungi, and viruses are serious issues in the aquaculture sector 19 . Antibiotics are the commercially accessible approach for treating infections; nevertheless, overuse over time leads to the evolution of resistant strains, rendering antibiotic treatments ineffective and failed the treatment 20 , 21 .…”

Cobalt complexes with bidentate (NO) versus monodentate (N) salicylaldimine ligands: Syntheses, crystal structures, and comparison in bioactivity profile against bacterial, fungal, and cancer cells and activities on wheat germination indices

“…[25][26][27][28][29][30][31][32][33] Salicylaldimines are multidentate neutral or anionic prodigious Schiff bases derived from substituted salicylaldehydes and amines. 34,35 Varied metal salicylaldimines are structurally characterized and their spectral, magnetic, catalytic, and redox characteristics can be tuned comparing with the metals. 36,37 These complexes are effective oxygenation and asymmetric catalysts, drugs and building blocks for liquid crystals, and functional supramolecular architectures.…”

“…Salicylaldimines are multidentate neutral or anionic prodigious Schiff bases derived from substituted salicylaldehydes and amines 34,35 . Varied metal salicylaldimines are structurally characterized and their spectral, magnetic, catalytic, and redox characteristics can be tuned comparing with the metals 36,37 .…”

A Novel Trinuclear Nickel(II) Salicylaldimine Complex: Synthesis, Structural Characterization, Bioactivity Profile against Bacterial, Fungal and Breast Cancer Cells and Effects on Wheat Germination Indices

“…An important class of the Schiff base ligands, derived from reactions between primary amines and salicylaldehydes, is the salicylaldimines [35,36]. These flexidentate ligands form complexes with tuned redox, magnetic and spectral characteristics with regard to the metals [37,38].…”