Preparation and chemical study on metallic bonding with antibiotics in nanometer form to raise the therapeutic efficiency: structural characterizations of Cu(II), Co(II) and Ni(II) 6-aminopenicillinic acid complexes

Abstract


 ABSTRACT. The medical and pharmaceutical areas are interested in the production of metal-biomolecule complexes because to their strong biological activity against bacteria, fungus, and cancers. The purpose of this paper was to synthesise of three coloured transition metal complexes of copper(II), cobalt(II), and nickel(II) with a 6-aminopenicillinic drug ligand (6-apen). The analyses of elemental analysis (carbon, hydrogen, and nitrogen), molar conductivity, magnetic susceptibility, infrared (FTIR), and electronic (UV-Vis) spectroscopy provided a thorough characterization of the solid complexes. The low molar conductance values of the produced solid complexes suggested that they were not electrolytic. The 6-apen drug ligand has more than one site of coordination as carboxylic group, β-lactam nitrogen, nitrogen of –NH2 group, oxygen of carbonyl β-lactam group and sulfur of the five–member ring. The microanalytical, spectroscopic and thermogravimetric analyses indicated a 1:2 (Metal : Ligand) stoichiometry of all complexes. The 6-apen ligand acts as a bidentate ligand that the coordination site occurs through the oxygen of deprotonated carboxylic group and β-lactam nitrogen. The thermogravimetric analysis confirmed the absence of crystalline water molecules outside the coordination sphere. The anticancer availability of the 6-apen free drug was checked against of 2Q7K receptor prostate cancer using a molecular docking calculation.
 
 KEY WORDS: 6-Aminopenicillinic, Coordination, Metals ions, FTIR, Molecular docking
 Bull. Chem. Soc. Ethiop. 2023, 37(1), 91-100. 
 DOI: https://dx.doi.org/10.4314/bcse.v37i1.8

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“…They are extensively used due to their high potency, low price, and lack of cross-resistance. The interactions of metal ions with FQs antibiotics have attracted considerable attention as these interactions improve the biological and pharmaceutical properties of FQs antibiotics [4][5][6].…”