Preparation and characterization of Zonyl-coated nanodiamonds with antifouling properties

Abstract

The paper reports on covalent linking of a modified amphiphilic polymer, the alkynyl-terminated Zonyl, to azide-terminated nanodiamonds by click chemistry. An analysis of the hybrid particle stability is presented based on size and zeta potential measurements. The antifouling character of the grafted nanodiamonds was investigated using bovine serum albumin as a model protein. The protein adsorption was quantified using a Bradford assay and found to be reduced by 30% in the presence of the Zonyl layer.

Nachrichten des Verbandes Biologie, Biowissenschaften & Biomedizin in Deutschland

“…We observed that the introduction of the polymeric film on FNDs caused a nearly fourfold reduction in the total adsorbed amount of BSA. This reduction slightly exceeds the 3.2‐fold reduction described for amphiphilic polymer zonyl‐coated NDs 19…”

“…Coating of NDs with polymeric shells appears to be a promising approach. After coating, ND particles exhibit an improved colloidal stability17, 19, 21–23 and reduced adsorption of blood proteins 19. Further functionalization of the polymeric shell has also been demonstrated 17.…”

“…Further functionalization of the polymeric shell has also been demonstrated 17. Introduction of azide and alkyne groups onto the ND surface and their subsequent reaction using azide–alkyne cycloaddition (click reaction) was recently reported 19. 24–27…”

“…The use of FNDs without any surface modification as fluorescent bioprobes or biosensors is limited for three major reasons: 1) nanodiamonds (NDs) precipitate in biological solutions,17, 18 2) proteins nonspecifically adhere to the ND surface,19 and 3) direct surface modifications of the ND surface are limited. The urgent need to overcome these limitations is evidenced by the large number of publications devoted to improving ND particle properties through various surface modifications (for a review, see Ref.…”

Insight into the Origin of the Positive Effects of Imidazolium Salt on Electrocatalytic Activity: Ionic Carbon Nanotubes as Metal‐Free Electrocatalysts for Oxygen Reduction Reaction

“…The positive zeta potentials of polyVBIM(Cl)-f-MWCNTs (+ 40.6 mV) and polyVIMPS-f-MWCNTs (+ 42.2 mV) clearly indicated that these poly(imidazolium salt)-functionalized CNTs possessed positive surface charges. [12] The zwitterionic polyVIMPS-f-MWCNTs, which have a higher positive surface charge, may possibly induce stronger polarization of pelectrons of CNTs. In addition, the sulfonate anion could bring protons into proximity of the electronically generated oxygen radical anion species, thereby enhancing the ORR rate.…”